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Obesity is highly heritable. Genetic variants showing robust associations with obesity traits have been identified through genome-wide association studies. We investigated whether a composite score representing healthy diet modifies associations of these variants with obesity traits. 32 BMI- and 14 waist-hip ratio (WHR)-associated SNPs were genotyped and genetic risk scores (GRS) calculated in 18
The modified phonon dispersion is of importance for understanding the origin of the reduced heat conductivity in nanowires. We have measured the phonon dispersion for 50 nm diameter InSb (111) nanowires using time-resolved X-ray diffraction. By comparing the sound speed of the bulk (3880 m/s) and that of a classical thin rod (3600 m/s) to our measurement (2880 m/s), we conclude that the origin of
Problemformulering: Byggprocessen är idag långsam, kostsam och genererar stora mängder spill och utsläpp. För att kunna möta bostadsbehovet från den snabbt växande befolkningsmängden måste tekniken utvecklas, den måste bli snabbare och mer kostnadseffektiv. Med ny teknik där betongelement tillverkas genom automatiserad och datorstyrd 3D-printning kan eventuellt hela betongbyggnadsprocessen effektiQuestion formulation: The construction process today is slow, costly and generates large amounts of waste and emissions. In order to meet housing needs of the rapidly growing population in a sustainable way, the technology must evolve; it must be faster and more cost-effective. New technology, where concrete is manufactured by automated and computer-controlled 3D-printing, can possibly streamline
The main purpose of this study is to investigate how members of staff at group homes (LSS-bostäder) reason about the service users’ rights to self-determination in everyday life. Additionally, this study aims to investigate how group homes as a place may affect the fulfillment of self-determination rights. The following theories “The theory of Recognition” and ”the Principle of normalization”, the
AbstractBackgroundThe increasing prevalence of obesity has led to a rise in bariatric surgery as an effective intervention for weight loss and associated co-morbidities. However, concerns persist regarding increased alcohol consumption after surgery.ObjectivesTo objectively assess long-term changes in alcohol use after bariatric surgery, we used the highly specific alcohol biomarker phosphatidylet
This study investigates the potential of large language models (LLMs), such as ChatGPT, to aid venture capitalists in the screening of startups that maximize sustainability impact. To determine the scope that maximizes impact for venture capitalists' and to identify effective screening criteria, the study utilized theoretical research and interviews. The thesis suggests that the ideal investme
Objective: To estimate the prevalence and incidence of non-gout crystal arthropathy in relation to socioeconomic factors in southern Sweden. Methods: All patients (age ≥ 18 years) with at least one visit to a physician with the diagnosis of interest in the Skåne region (population of 1.3 million) in 1998-2014 were identified. Non-gout crystal arthropathy (ICD-10 codes M11.0-M11.9) was subclassifie
The unfolding COVID-19 pandemic, and the unprecedented social and economic costs it has inflicted, provide an important opportunity to scrutinize the interplay between the resilience of small and medium-sized enterprises (SMEs) and the resilience of the communities they are embedded in. In this article, we articulate the specific ways that SMEs play a crucial, and underappreciated role in building
Ageing in the human brain is a major risk factor for most neurodegenerative diseases. Yet the cell-type-specific molecular changes that contribute to this risk remain poorly understood. This thesis investigates cell-type-specific changes across multiple levels of molecular regulation and their roles in physiological and pathophysiological brain ageing. Using single-nucleus RNA sequencing of postmo
Background: – Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is rare in children, and results in kidney failure in up to one third of cases. There is very limited knowledge on kidney transplantation in childhood-onset AAV. We assessed kidney transplantation outcomes and prognostic factors in a multicentre cohort of patients with childhood-onset AAV.Methods: – Patients diag
Low back pain is common and negatively impacts quality of life and workplace productivity. However, few studies have focused on small- and medium-sized enterprises (SMEs) where risk factors are prevalent. This cross-sectional study examined the association and structural relationships between physical and social factors in low back pain among Japanese SME workers. We analyzed survey data collected
The activity and stability of an electrocatalyst is governed by the structural and chemical changes occurring at the solid–liquid interface. While single crystal electrodes have often served as model systems to elucidate structure–function relationships, extending these insights to more realistic polycrystalline electrodes requires experimental techniques with spatial resolution that can operate u
Using ultra-broadband transient terahertz (THz) spectroscopy, complemented by transient absorption (TA) and photoluminescence (PL) measurements, we directly track the generation and relaxation of photoexcited hot carriers, as well as the ultrafast formation of excitons in the transition metal phosphorus trichalcogenide NiPS3, with a temporal resolution of sub-100 fs. A subset of excitons exhibits
Aim Habitual physical activity (PA) affects metabolism and homeostasis in various tissues and organs. However, detailed knowledge of associations between PA and cardiovascular disease (CVD) risk markers is limited. We sought to identify associations between accelerometer-assessed PA classes and 183 proteomic and 154 metabolomic CVD-related biomarkers. Method We utilized cross-sectional data from t
Objective: To evaluate the effects of excluding fatty tissue in QSM of human knee cartilage. Materials and methods: Gradient echo images from 18 knee-healthy volunteers were acquired, from which chemical shift corrected field perturbation maps were calculated. Based on these, QSM maps were reconstructed using morphology enabled dipole inversion and one of three masking alternatives: (1) excluding
Adaptive haptics, an amalgamation of different haptic systems and machine learning algorithms, has the potential for intelligent feedback in healthcare. Such systems are capable of learning to suit individual user needs in real-time, thereby improving patient care, medical education, and treatment. Targeted techniques of machine learning approaches are reinforcement learning, neural networks, supp
We present a superconducting cavity-coupled double quantum dot (DQD) photodiode that achieves a maximum photon-to-electron conversion efficiency of 25% in the microwave domain. With a higher-quality-factor cavity and improved device design to prevent photon leakages through unwanted pathways, our device measures microwave signals down to the 100-aW power level and achieves sensitivity to probe mic
Correlated electron physics is intrinsically a multiscale problem, since high-energy electronic states screen the interactions between the correlated electrons close to the Fermi level, thereby reducing the magnitude of the interaction strength and dramatically shortening its range. Thus the handling of screening is an essential ingredient in the first-principles modeling of correlated electron sy
Transposable elements (TEs) are mobile genetic sequences comprising around 50% of human DNA. TEs shape gene regulatory networks in development, pluripotency and inflammation, and are implicated in a number of neurological disorders. Therefore, TEs are tightly controlled by epigenetic regulators which form a complex repressive network throughout different stages of development. However, while the r
