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Voice problems are common among workers in occupations with high demands on oral communication. For sustaining vocal health, it is important to find efficient ways for how to reduce strain on the voice at work, and one way to do so is optimizing the room acoustics for communication. However, to date we do not know enough about what kind of room acoustic conditions that support voice and speech mos
Smart microscopy lies at the intersection of biology, optics, engineering, and computer science. Unlike traditional microscopes, smart systems actively adapt their acquisition settings in real time based on information extracted from the sample, allowing experiments to navigate competing demands such as resolution, speed and sample health. In this review, we present a practical framework for what
Background Previous population-based studies suggest an increased risk of suicide in Parkinson’s disease (PD), but findings have been inconsistent and often limited by residual confounding. We examined the association between incident PD and suicide-related outcomes using extensive confounding control, including both suicidal attempts and suicide.Methods We conducted a nationwide matched cohort stBackground Previous population-based studies suggest an increased risk of suicide in Parkinson’s disease (PD), but findings have been inconsistent and often limited by residual confounding. We examined the association between incident PD and suicide-related outcomes using extensive confounding control, including both suicidal attempts and suicide.Methods We conducted a nationwide matched cohort st
Traumatic brain injury and stroke often result in contralateral sensorimotor deficits, including asymmetric posture. While these lateralized effects are classically attributed to neural tract disruption, recent evidence supports the existence of a complementary humoral pathway. Our previous work demonstrated that the neurohormone Arg-vasopressin (AVP) mediates right hindlimb responses to left-side
The dissociation of NO is a critical step in its catalytic reduction to N2, which is key to automotive exhaust treatment. Here, we examine the role of Rh atomic steps in the NO dissociation reaction under 0.05 mbar NO. We use a Rh crystal sample curved around the (111) direction and ambient-pressure X-ray photoelectron spectroscopy to probe different Rh surfaces subject to the very same reaction c
Nanoplastics are increasingly being recognized as a global pollutant. However, relatively few studies report directly measured concentrations of nano- and microplastics in environmental samples, although available data suggest levels of up to 0.5 mg L−1 in lake water, which is surprisingly high. Their degradation in the environment, particularly under UV irradiation, is still poorly understood. He
We must recognize that plastics likely constitute a pervasive background in many environments. Beyond their previously documented risks to ecosystems and human health, plastics may also exert unintended influences on laboratory experiments, potentially distorting experimental outcomes. Here, we demonstrate that ultrasound treatment of commonly used laboratory test tubes releases nanoplastics into
Attosecond pulses produced by high-order harmonic generation in gases driven by intense laser fields have become a cornerstone technique for probing ultrafast electronic motion in matter. These applications require a good knowledge of the temporal and spectral properties of the emitted radiation. In this work, we generate a train of two to three attosecond pulses that we characterize using two-col
Photoionization of atoms by high-order harmonics in the presence of a laser may lead to quantum interference from which information about the photoionization dynamics or the light fields can be extracted. Traditionally, this interference arises from two-photon transitions involving the absorption of consecutive harmonics combined with the absorption and stimulated emission of a laser photon. In th
AimImpaired vibrotactile sense, mirroring diabetic peripheral neuropathy, is present among children and adolescents with type 1 diabetes. This study aims to re-examine the vibrotactile sense of paediatric type 1 diabetes subjects in order to evaluate any alterations in the vibrotactile sense over time.MethodsA VibroSense Meter I device was used to determine the vibrotactile perception thresholds (
Small Cajal body-specific RNAs (scaRNAs) guide post-transcriptional modification of spliceosomal RNA and, while commonly altered in cancer, have poorly defined roles in tumorigenesis. Here, we uncover that SCARNA15 directs alternative splicing (AS) and stress adaptation in cancer cells. Specifically, we find that SCARNA15 guides critical pseudouridylation (Ψ) of U2 spliceosomal RNA to fine-tune AS
Aims: The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure. Methods and results: The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and perf
Recent advances in stroke treatment have provided effective tools to successfully treat ischemic stroke, but still a majority of patients are not treated due to late arrival to hospital. With modern stroke treatment, earlier arrival would greatly improve the overall treatment results. This prospective study was performed to asses the capability of bilateral accelerometers worn in bracelets 24/7 to
B lymphocyte development is dependent on the interplay between the chromatin landscape and lineage-specific transcription factors. It has been suggested that B lineage commitment is associated with major changes in the nuclear chromatin environment, proposing a critical role for lineage-specific transcription factors in the formation of the epigenetic landscape. In this report, we have used chromo
BACKGROUND: Risk factors for Parkinson's disease (PD) can be more or less relevant to a population due to population-specific genetic architecture, local lifestyle habits, and environmental exposures. Therefore, it is essential to study PD at a local, regional, and continental scale in order to increase the knowledge on disease etiology.OBJECTIVE: We aimed to investigate the contribution of geneti
Up to 10% of pediatric cancer patients harbor pathogenic germline variants in one or more cancer susceptibility genes. A recent study from the US reported pathogenic variants in 22 out of 60 analyzed autosomal dominant cancer susceptibility genes, implicating 8.5% of pediatric cancer patients. Here we aimed to assess the prevalence of germline pathogenic variants in these 22 genes in a population-
We recently found a negative association between body mass index (BMI) and the risk of localised prostate cancer (PCa), no association with advanced PCa, and a positive association with PCa‐specific mortality. In a 15% subpopulation of that study, we here investigated the measures of abdominal adiposity including waist circumference (WC) and A Body Shape Index (ABSI) in relation to PCa risk and mo
