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Genes encoding B lineage–restricted transcription factors are frequently mutated in B-lymphoid leukemias, suggesting a close link between normal and malignant B-cell development. One of these transcription factors is early B-cell factor 1 (EBF1), a protein of critical importance for lineage specification and survival of B-lymphoid progenitors. Here, we report that impaired EBF1 function in mouse B
AIMS: Our aim was to study the incidence of type 2 diabetes in a population-based cohort of Swedish and Iraqi born individuals, focussing on traditional risk factors, insulin action, insulin secretion and ethnicity.MATERIALS AND METHODS: The cohort consisted of 1164 Iraqi and 693 Swedish-born citizens. We investigated the association between new-onset type 2 diabetes and the predictors including l
Recent advancements in cell engineering have succeeded in manipulating cell identity with the targeted overexpression of specific cell fate determining transcription factors in a process named transcriptional programming. Neurogenin2 (NGN2) is sufficient to instruct pluripotent stem cells (PSCs) to acquire a neuronal identity when delivered with an integrating system, which arises some safety conc
Introduction: Despite the publication of clinical practice guidelines, the quality of the care process as experienced by patients with osteoarthritis (OA) appears suboptimal. Hence, this study investigates how patients with OA experience their disease and care process, highlighting potential elements that can enhance or spoil it, to optimise their quality of care. Methods: A qualitative study base
BACKGROUND: Creatinine-based equations are the most used to estimate glomerular filtration rate (eGFR). The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), the re-expressed Lund-Malmö Revised (r-LMR) and the European Kidney Function Consortium (EKFC) equations are the most validated. The EKFC and r-LMR equations have been suggested to have better performances in young adults, but this
In this study, a report is prepared on significantly low specific contact resistivity of alloyed and non-alloyed ohmic contacts fabricated on an as-grown n+-GaN layer and measured with the transfer length method. A low ρc = 8 × 10−8 Ω cm2 is extracted for the alloyed Ti/Al/Ni/Au, and ρc = 4 × 10−7 Ω cm2 for the unannealed Ti/Pd/Au. To achieve these, a highly doped n+-GaN layer with ND = 1.5 × 1019
Neuroblastoma exhibits two cellular phenotypes: therapy-sensitive adrenergic (ADRN) and therapy-resistant mesenchymal (MES). To understand treatment response, it is important to elucidate how these phenotypes impact the dynamics of cancer cell populations and whether they represent distinct cell types or dynamic cell states. Here, we use an integrated experimental and mathematical modeling approac
The ongoing climate change has been increasingly reflected in climate observations around the world, both in terms of averages and extremes, and attributed to anthropogenic climate forcing. When it comes to changing extremes, attribution to climate change is now especially well-established for heat-related extremes worldwide. Understanding changes in extremes is important for climate adaptation as
State-of-the-art laser frequency stabilization is limited by miniscule length changes caused by thermal noise. In this work, a cavity-length-insensitive frequency stabilization scheme is implemented using strong dispersion in a 21 mm long cavity with a europium-ion-doped spacer of yttrium orthosilicate. A number of limiting factors for slow light laser stabilization are evaluated, including the in
We present an operando study where Ambient-Pressure X-ray Photoelectron Spectroscopy (AP-XPS), Polarization Modulation-InfraRed Reflection Absorption Spectroscopy (PM-IRRAS) and Mass Spectrometry (MS) were employed simultaneously with sub-minute time resolution to monitor the CO oxidation and NO reduction reactions on Rh(111). AP-XPS is a powerful tool to follow reactions at the surface-gas interf
LTx remains the definitive treatment for end-stage lung disease, but the increasing demand for donor lungs outpaces the available supply. This chapter explores innovative approaches to expand the pool of viable donor lungs and reduce waiting times, which is crucial to lowering mortality rates among patients on transplant lists. Xenotransplantation, which has made its greatest strides using porcine
As advancements in transplantation techniques continue, the challenge remains the limited availability of suitable donor organs. This chapter explores strategies to expand the donor pool and optimise transplant outcomes, which include the use of extended criteria donors, living lobar transplantation, donor-to-recipient graft size matching, and innovations in hypothermic storage and ex vivo lung pe
Extracellular vesicles (EVs) carry biological information from their parent cell to other cells in the body. To intercept and decipher this information necessitates the isolation of EVs from complex backgrounds such as blood or spinal fluid. Acoustic trapping has been previously demonstrated as a promising technique for EV isolation from cell media, blood plasma and urine. The acoustic fields stru
Although outcomes for newly diagnosed acute myeloid leukaemia (AML) have been incrementally improved over the last decades, management of relapsed and refractory (R/R) AML remains a medical challenge. A curative intent for R/R AML usually involves chemotherapy (with or without targeted therapy) with subsequent consolidation, including allogeneic haematopoietic stem cell transplantation. Despite th
Gold particles are commonly used as catalysts in the vapor-liquid-solid (VLS) growth of GaAs nanowires, but the incorporation of gold into the nanowires can negatively affect their electronic and optical properties. In this work, we investigate the equilibrium concentration of Au in GaAs nanowires using density functional theory calculations combined with thermodynamically assessed chemical potent
We present a quantum repeater protocol for distributing entanglement over long distances, where a dedicated communication stage enables trial rates not limited by the travel time between repeater nodes. To accomplish this, each node contains several qubits that can couple to one single-photon emitter. Photons from the emitters in neighboring nodes generate heralded entanglement between qubits in t
The instability of perovskite interfaces caused by interfacial defects and heterojunction evolution hinders the realization of long-term stable inverse perovskite solar cells (IPSCs). This work reports a strategy for the study of heterojunction evolution, the effects of buried interface and carrier dynamics on the stability of perovskite films and devices in 2D/3D heterojunctions. The emphasis is
