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BACKGROUND: An increasing number of monogenic conditions underlying stroke are being identified. We explored the possibilities of increasing the diagnostic yield of monogenic stroke in a population under 56 years of age. METHODS: Fifty probands ≤55 years at their first stroke episode were characterized clinically and investigated by whole genome sequencing. Probands had one or more of: (1) one or
Background: The European Union recently recommended evaluation of the feasibility of organised prostate cancer screening. In Sweden, regional population-based organised prostate cancer testing (OPT) programmes were introduced in 2020. Objective: To describe initial participation rates and diagnostic outcomes. Design, setting, and participants: The three most populated Swedish regions invited all m
Haematopoietic stem cell (HSC) self-renewal is a process that is essential for the development and homeostasis of the blood system. Self-renewal expansion divisions, which create two daughter HSCs from a single parent HSC, can be harnessed to create large numbers of HSCs for a wide range of cell and gene therapies, but the same process is also a driver of the abnormal expansion of HSCs in diseases
This chapter provides a brief yet comprehensive overview of the state-of-the-art in semiconductor characterization using spectroscopic ellipsometry. The concept of ellipsometry as optical technique to determine the state of polarization of light reflected or transmitted from complex-structured and multiple layered semiconductor materials is introduced and laid out in the framework of the Jones vec
We investigated the role of cultural experience in the search advantage for happy faces. European British participants living in the UK, Asian Japanese participants living in Japan, and Asian Japanese participants living in the UK, were required to search for a happy or an angry face target against a background of neutral facial expressions, using Asian Japanese and European American faces. Result
Electron paramagnetic resonance of Cr3+ ions in β -Ga2O3 is investigated using terahertz spectroscopic ellipsometry under magnetic field sweeping, a technique that enables the polarization resolving capabilities of ellipsometry for magnetic resonance measurements. We employed a single-crystal chromium-doped β -Ga2O3 sample, grown by the Czochralski method, and performed ellipsometry measurements a
X-ray fluorescence emission spectroscopy is a powerful tool to gain chemical information on a wide variety of samples. Its combination with focused X-ray beams and translation stages enables X-ray fluorescence microscopy, generating quantitative distribution maps for sets of chemical elements, depending on incident photon energy and detector specifications. The use of synchrotron radiation for X-r
OBJECTIVE: To explore the associations between daily time in sedentary behaviour (SED) and physical activity (PA) with perceived physical capacity, health-related quality of life (HRQoL) and fatigue in persons with post COVID-19 condition (PCC). An additional objective was to describe changes in SED and PA levels over three months.MATERIALS AND METHODS: Individuals with PCC self-reported on physic
Supported lipid bilayers (SLBs), formed via lipid vesicle adsorption on highly curved silica surfaces, are widely used in biosensor applications and as models for curved cell membranes. However, SLB formation is often hindered on convex structures with radii comparable to the vesicles. In this study, lightguiding semiconductor nanowires (NWs), engineered for fluorescence signal enhancement, were u
Since 2011, LUNARC has aimed to provide an interactive HPC environment for its resource users. Several different architectures have been used, but since 2013, we have been using a remote desktop environment based on Cendio's ThinLinc [1] combined with a custom backend framework, GfxLauncher [2], supporting hardware-accelerated graphics applications and Jupyter Notebooks [3] submitted to the backen
Japan's January withdrawal of funding from the UN Committee on the Elimination of Discrimination against Women highlights its aversion to addressing gender equality issues at home. Despite externally presenting a commitment to progressive gender norms, a tension between Japan's international image and its domestic reality persists. Japan continues to rank low in major gender equality indexes as re
Objective: The antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides are heterogeneous disorders. The aim of this study was to identify and characterize subgroups of patients based on sex, ANCA, age at diagnosis, and organ involvement. Methods: In total, 1,167 patients with granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA) were retrospectively recruited to the s
Catalytic studies traditionally rely on steady-state conditions resulting in time-averaged datasets that do not differentiate between active and spectator species. This limitation can cause misinterpretations of catalytic function, as the signal of short-lived intermediates responsible for producing desired reaction products is often masked by more intense spectator species. Time-resolved ambient
Background: Hexavalent chromium (Cr(VI)) is a lung cancer carcinogen. However, the genotoxic and mutagenic effects of Cr(VI) in humans at low-to-moderate occupational exposure levels are unknown. This study aims to investigate the relationship between occupational exposure to Cr(VI) and the presence of oxidative damage, genetic and epigenetic alterations. Methods: We included 113 Cr(VI) exposed wo
Non-polar and semi-polar III-nitrides have beneficial properties for various electronic applications such as light emitting diodes and photodetectors due to the elimination or reduction of polarization effects. However, cost-effective manufacturing of non-polar and semi-polar III-nitride films with sufficient film quality is not feasible yet. We report an investigation of the morphological and str
High-speed vertical III–V nanowire transistors utilize their channel material for high frequency and low noise performance. A device layout revision to optimize gate resistance, in a trade-off to gate-source capacitance, is presented. A two-step redesign of the established device layout is proposed. First step is demonstrated with fabricated structures. The second step predicts the design transiti
AbstractBackgroundThe increasing prevalence of obesity has led to a rise in bariatric surgery as an effective intervention for weight loss and associated co-morbidities. However, concerns persist regarding increased alcohol consumption after surgery.ObjectivesTo objectively assess long-term changes in alcohol use after bariatric surgery, we used the highly specific alcohol biomarker phosphatidylet
By optically sensing mid-infrared absorption through a visible probe beam, mid-infrared photothermal (MIP) microscopy has emerged as a powerful tool for chemical imaging with micromolar sensitivity and submicron spatial resolution. The adoption of spatially multiplexed camera-based widefield detection further enhanced the imaging speed. However, current widefield MIP systems suffer from a small fi
1 STAKEHOLDER INTERACTION IN RESEARCH PROCESSES - A GUIDE FOR RESEARCHERS AND RESEARCH GROUPS Daniel Slunge, Olof Drakenberg, Anders Ekbom, Maria Göthberg, Åsa Knaggård and Ullrika Sahlin, 2017 In many research projects, stakeholder interaction is ad hoc rather than strategic and systematic. This guide provides advice on good practice, strategies and tools for researchers and research groups inte-
