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A Swedish translation of the Barrow Neurological Institute Screen for Higher Cerebral Functions was administered to 52 normal control subjects and 36 patients with well-documented brain dysfunction. Findings replicated those reported in American samples. Level of performance was strikingly similar between Swedish controls and American controls, especially in individuals between 15 and 39 years. Sw
Objectives: To assess the usefulness of hand function measurements in a study of treatment effects of tumour necrosis factor (TNF) blockers and to define the relationship between different hand function tests and also relate hand function to general disability and disease activity. Methods: The study group consisted of 49 patients with established rheumatoid arthritis (RA) who were followed for 1
Sequential Monte Carlo (SMC) methods have demonstrated a strong potential for inference on the state variables in Bayesian dynamic models. In this context, it is also often needed to calibrate model parameters. To do so, we consider block maximum likelihood estimation based either on EM (Expectation-Maximization) or gradient methods. In this approach, the key ingredient is the computation of smoot
The development of inhibitory antibodies to factor VIII is a serious complication of haemophilia. Two haemostatic agents with different bypassing mechanisms have been used in the treatment of patients with inhibitors: activated prothrombin complex concentrate (aPCC) and recombinant factor VIIa (rFVIIa). The objective was to compare cost and outcome of aPCC and rFVIIa in the treatment of joint blee
Thioredoxin (Trx)-1 is a small, ubiquitously expressed redox-active protein with known important cytosolic functions. However, Trx1 is also upregulated in response to various stress stimuli, is found both at the cell surface and secreted into plasma, and has known anti-inflammatory and antiapoptotic properties. Previous animal studies have demonstrated that exogenous Trx1 delivery can have therape
Human-mouse hybridoma cell lines producing human monoclonal antibodies against the cardiac glycoside digoxin were established after in vitro immunization or direct immortalization of human peripheral blood lymphocytes with digoxin. Three antibodies, designated M06, LH92 and LH 1 14, displayed different patterns of fine specificity against digoxin and several digoxin analogues, as elucidated by inh
The aim of this study was to evaluate the ability of intravascular ultrasound to diagnose tumor involvement of the portal and the superior mesenteric veins using the preoperative percutaneous, transhepatic approach, and to compare the findings with those made at concomitant direct portography, surgery, and histopathological examination. Ten patients with a preoperative diagnosis of a resectable tu
Electrical characteristics of living tissues have been investigated for a long time in the search for further methods to complement the traditional investigations of pathology and physiology. Tumour tissue has been shown to exhibit a larger permittivity and conductivity than normal tissues. This might be associated with the fact that tumour cells have a higher water content and sodium concentratio
Conversion of lignocellulosic material to monomeric sugars and finally ethanol must be performed at low cost, i.e, with limited consumption of chemicals, yeast and enzymes while still reaching high yields, if it is to compete with other fuel conversion processes. The objective of this study was thus to investigate ethanol production from steam-pretreated wheat straw by simultaneous saccharificatio
Objective: To determine the importance of antibodies against phosphorylcholine (PC) and oxidized low density lipoprotein (OxLDL) for development of atherosclerosis. Methods and results: Two hundred and twenty six individuals with established hypertension (diastolic pressure > 95 mmHg) were from European Lacidipine Study on Atherosclerosis. Antibodies of IgG and IgM subclass were tested by ELISA ag
Patients with an implantable cardioverter defibrillator (ICD) have an ongoing risk of sudden incapacitation that might cause harm to others while driving a car. Driving restrictions vary across different countries in Europe. The most recent recommendations for driving of ICD patients in Europe were published in 1997 and focused mainly on patients implanted for secondary prevention. In recent years
Aims/hypothesis: Mutations in hepatic nuclear factor 1alpha cause a monogenic form of diabetes, maturity onset diabetes of the young type 3 (MODY3). Our aim was 1) to assess the uptake of genetic testing for MODY3 and to determine factors affecting it, and ( 2) to compare attitudes to predictive genetic testing between families with MODY3 and a previously studied group at risk of hereditary nonpol
This study explored nurses' narrations about and reflections on caring for patients with severe dementia and their interpretation of the meaning for patients as revealed in clinical supervision sessions. The encounters between patient and nurse could confirm or threaten the patient's identity as a person or the nurse's identity as a person and a professional. Nurses searched for the meaning of the
The Convention on the Rights of Persons with Disabilities (CRPD), adopted by the UN in 2006, represents the coming of age of a human rights approach to disability. In doing so, it provides answers to the questions what ‘disability’ is, who ‘persons with disabilities’ are and what entitlements are legitimate and relevant in relation to ‘disability’. Partly, these answers flow from the heritage of i
Popular Abstract in Swedish Patienten med underbensamputation på grund av kärlsjukdom Långt före Kristi födelse var amputation av benet en känd operation. Anledningen till amputationen kunde vara kärlsjukdom, olycksfall, tumör eller medfödda missbildningar. I västvärlden idag utförs 90 % av amputationerna på grund av kärlsjukdom. Dessa patienter är äldre och sjukare än övriga benamputerade och meThe patient with unilateral trans-tribal amputation for vascular disease. Functional assessments, prognostic factors and cost of prostheses. The aims of the study were to focus on the functional ability of the dysvascular patient with unilateral trans-tibial amputation and the early rehabilitation period, defined here as the period between the amputation and the prosthetic fitting. Results revea
Background: With an increased life expectancy for the general population as well as for those ageing with chronic diseases, there are major challenges to the affected individuals and their families, but also to health care and societal planning. Most important, an increasing proportion of older people remain living in their ordinary homes despite health decline and disability. However, little is k
