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Introduction: Elevated pulmonary vascular resistance (PVR) is observed in both physiological and pathological states. Pulmonary hypertension (PH) is a condition associated with significant morbidity and mortality in neonates and children and curative pharmacotherapy is lacking in most cases. In utero, a high PVR allows for blood to bypass the lungs through the open ductus arteriosus (DA). Vascular
Liquid crystalline nanoparticles (LCNPs), e.g. cubosomes and hexosomes, are receiving more and more attraction as drug delivery vehicles. Dry powder formulation that forms LCNPs upon hydration can be advantageous to make new routes of administration accessible. In this work, we investigate use of three disaccharides (lactose, trehalose and sucrose) as protective matrices for glycerol monooleate ba
The aim of this chapter is to analyse and describe how teachers’ use of theoretical conjectures in instruction during a Learning Study (LeaS) process affected high-functioning autism spectrum disorder (HFASD) students’ learning outcomes when following the national curriculum. Participants were students in grades 7 to 9 (n = 11) and their teachers (n = 5). The 11 adolescents (4 females and 7 males)
Platform trials have become widely adopted across multiple disease areas over recent years, however, guidelines for operationalising these trials have not kept pace. We outline a series of documents that summarise the statistical components, and implicit processes, of the Staphylococcus aureus Network Adaptive Platform (SNAP) trial to provide an informal template for other researchers and reviewer
INTRODUCTION: The FEV1 quotient (FEV1Q), calculated as the index between FEV1 and a theoretical lower survivable FEV1 threshold of 0.4L for females and 0.5L for males, has been investigated as a novel method of interpreting results from lung function testing. The applicability of the FEV1Q in populations with chronic respiratory failure has not been studied, and the continuous association between
Despite the centrality of research phenomena, the process of their definition is often neglected and reduced to a simple choosing of pre-established subjects of interest. However, good research not only includes empirical work aimed at more or less ‘given as fact’ phenomena. It also involves phenomena construction: that is, the process of generating and establishing phenomena to investigate and th
AIM: To explore HPs' perceptions of working on lifestyle management for patients with early rheumatoid arthritis (RA). METHODS: In this qualitative study, individual interviews were conducted with 20 HPs. Qualitative content analysis was used, and three categories and six subcategories were identified. RESULTS: HPs' perceptions of working on lifestyle management for patients with early RA revealed
Chiral compounds containing nitrogen heteroatoms are fundamental substances for the chemical, pharmaceutical and agrochemical industries. However, the preparation of some of these interesting scaffolds is still underdeveloped. Herein we present the synthesis of a family of P-stereogenic phosphinooxazoline iridium catalysts from L-threonine methyl ester and their use in the asymmetric hydrogenation
Inclusive and differential measurements of the top–antitop (Formula presented.) charge asymmetry (Formula presented.) and the leptonic asymmetry (Formula presented.) are presented in proton–proton collisions at s = 13 TeV recorded by the ATLAS experiment at the CERN Large Hadron Collider. The measurement uses the complete Run 2 dataset, corresponding to an integrated luminosity of 139 fb−1, combin
Background: Older adults have complex medical needs that causes increased use of resources at the emergency department (ED). The prevalence of non-specific complaint (NSC) as a chief-complaint in the ED is common among older adults and is not prioritized even though possibly having worse clinical outcome. The objective was to study hospital admission and mortality for older adults visiting the ED
We report on an exact theory for ensembles of globally coupled, heterogeneous complex Riccati equations. A drastic dimensionality reduction to a few ordinary differential equations is achieved for Lorentzian heterogeneity. By applying this technique, we obtain low-dimensional firing-rate equations for populations of spiking neurons with a clustered substructure.
Background: Congenital heart disease (CHD) is the most common organ anomaly in humans affecting approximately 1:125 newborns worldwide. Early diagnosis enables postnatal stabilisation and may improve outcomes, especially in critical CHD, in which the circulation is dependent on patency of the arterial duct. Detection of CHD in newborns remains incomplete and current screening programs do not aim t
Objective: This study aims to provide a deeper understanding of what persons with lived experience and professionals with experience of patient safety, suicide research, and investigations consider to be most important in investigations of healthcare before suicide to learn and improve the care of suicidal patients. Method: This is a qualitative study based on 15 semistructured interviews with per
PURPOSE: Techniques for endovascular thrombectomy in acute ischemic stroke due to medium or distal vessel occlusions (MDVO) need to be improved, and first-line aspiration is emerging as a promising technique. The objective was to describe first-pass and final reperfusion rates with a triaxial direct aspiration first pass technique (ADAPT) and a novel, quadriaxial technique (QUATTRO-ADAPT) using RE
BACKGROUND: Selective glomerular hypofiltration syndrome (SGHS), formerly shrunken pore syndrome, an emerging marker of glomerular dysfunction, is associated with worsened prognosis in cardiovascular disease, but its role in kidney failure remains underexplored. Osteopontin (OPN) is associated with worsening kidney function and prognosis in chronic kidney disease.PURPOSE: To explore if increased l
INTRODUCTIONThis study examines medication reviews (MRs) among people living with dementia (PWD) in Sweden, focusing on frequency and factors influencing access.METHODSUsing nationwide register data, all diagnosed PWD from 2010 to 2016 were assessed for MR receipt in 2015 and/or 2016. The analysis guided by the Andersen healthcare utilization framework, considered predisposing, enabling, and need-
Few existing studies have delved into individual-level attitudes towards the exchange of sexual services for payment, leaving a significant gap in our understanding. Various studies have speculated about how certain demographic factors and attitudes may shape people's perceptions of causes and consequences relating to such exchanges, but none have directly investigated this topic. To bridge this g
