Sökresultat

The dense accumulation of α-Synuclein fibrils in neurons is considered to be strongly associated with Parkinson’s disease. These intracellular inclusions, called Lewy bodies, also contain significant amounts of lipids. To better understand such accumulations, it should be important to study α-Synuclein fibril formation under conditions where the fibrils lump together, mimicking what is observed in

In this article, a novel vector network analyzer (VNA)-based ultrawideband (UWB) channel sounder using radio-over-fiber (RoF) techniques is presented. Benefiting from the usage of optical fiber cable, the measurement range and the dynamic range are significantly increased compared with the conventional coaxial-based VNA system. Specifically, using RoF increases the dynamic range to a maximum of 11

Aims: To investigate what NSE levels predict long-term neurological prognosis at 24, 48 and 72 hours after ROSC in a cohort of out-of-hospital cardiac arrest and to validate previously suggested NSE cut-offs, including the latest ERC guidelines (2021). Methods: Patients admitted to intensive care units in four hospitals in Southern Sweden between 2014–2018 were included. Blood samples were handled

Supercritical heat transfer deterioration can be found in active regenerative cooling processes. Thermal pyrolysis occurs once the temperature of the hydrocarbon fuel exceeds a certain value. To investigate the influence of thermal pyrolysis on the heat transfer behavior and flow-upward characteristics in a rectangular channel, the wall temperature distribution, thermal acceleration, mass fraction

This paper sets out to create an implementation for fingerprint-based positioning using massive multiple-input multiple-output (MIMO) technology, by means of deep convolutional neural networks (CNN), and utilizing the wireless channel state information (CSI). Due to the sheer volume of computational requirements imposed by CNN processing, an accelerator-assisted design is well-suited to the task a

The etiology of hereditary ataxia syndromes is heterogeneous, and the mechanisms underlying these disorders are often unknown. Here, we utilized exome sequencing in two siblings with progressive ataxia and muscular weakness and identified a novel homozygous splice mutation (c.3020-1G > A) in neurofascin (NFASC). In RNA extracted from fibroblasts, we showed that the mutation resulted in inframe ski

We recently reported that differential gene expression and DNA methylation profiles in blood leukocytes of apparently healthy smokers predicts with remarkable efficiency diseases and conditions known to be causally associated with smoking, suggesting that blood-based omic profiling of human populations may be useful for linking environmental exposures to potential health effects. Here we report on

Reduced fibrinolytic capacity due to increased plasminogen activator inhibitor-1 (PAI-1) activity in plasma is a common finding in patients with coronary heart disease or venous thromboembolism, although its clinical significance is debated. Recently, a dimorphism in the PAI-1 promoter (4G-5G) has been reported and homozygosity for the 4G allele is associated with increased transcription and highe

All-polymer blends are promising materials for organic electronics. Their performance critically depends on the quality of mixing of the electron donor and acceptor polymers and on the local chain organization. We investigated spatially resolved photoluminescence properties of as-prepared and annealed blends of poly[2,3-bis(3-octyloxyphenyl)quinoxaline-5,8-diyl-alt-thiophene-2,5-diyl] (TQ1) and po

We compared, head-to-head, the old generation Actigraph model 7164 with the new generation Actigraph GT1M accelerometer. A total of 15 randomly selected teenagers (eight girls and seven boys) were investigated. They performed a treadmill test wearing the two kinds of accelerometers around the waist simultaneously. The treadmill test consisted of three different levels of speed 4, 6 and 8 km h(-1)

The habitat distribution of red-listed plants, fungi and animals that have been found in the central parts of the parish of Stenbrohult, southern Sweden since 1970 is presented (Tables 1-4). In the centre of the 5 000 ha study area Carl Linnaeus was born in 1707, and he spent his summers there until 1727. In 1971-2002 at least 183 red-listed species have been found, with 73 wood-living beetle spec

Aim: Acute otitis media (AOM) is a common childhood disease, which often becomes recurrent (rAOM). A small reduction of AOM episodes has been noted in unselected child cohorts after vaccination with heptavalent conjugate pneumococcal vaccine (PCV7). The purpose of this study was to investigate how vaccination affects young children at risk of developing rAOM. Methods: Ninety-six children with an A

Popular Abstract in English Internal combustion engine plays an important role in our society. In our daily life, we use them to drive cars, trucks, ships, generating electricity and heat, and in many other applications. Modern internal combustion engines fall into three catalogues: gasoline engines, diesel engines and low temperature compression ignition engine. They are developed to achieve highThis thesis deals with direct numerical simulation (DNS) of low temperature combustion in internal combustion engine related conditions. In particular, HCCI (homogeneous charge compression ignition), SACI (spark assisted ho-mogeneous charge compression ignition) and PPC (partially premixed charge combustion) were investigated to gain deeper understanding on the details of the combustion process. I

BACKGROUND: In Crohn's disease high tissue expression and serum levels of chemokines and their receptors are known to correlate with disease activity. Because statins can reduce chemokine expression in patients with coronary diseases, we wanted to test whether this can be achieved in patients with Crohn's disease. METHODOLOGY/PRINCIPAL FINDINGS: We investigated plasma levels of chemokines (CCL2, C

Hepatitis D virus (HDV) is dependent on the presence of hepatitis B virus (HBV) for transmission and replication because of its inability to produce its own coat. It remains unclear whether HDV infection increases the risk of hepatocellular carcinoma. Using the Swedish Hospital Discharge Register and Outpatient Registry, we identified 9160 patients with chronic HBV infection between 1997 and 2008,

Food insecurity is a persistent challenge in the developing world, particularly the Sub-Saharan African region. Based on the latest report on the state of the World Food Insecurity, an estimate of 28% of the population in the Sub-Saharan Africa is recorded to be malnourished. This enduring challenge, therefore, requires further studies to shed light on the underlying causes of the problem and find

Digital platforms is an innovation made possible by the adoption of computers and internet. Companies like Google and Facebook grew in relatively short time to the most valuable or-ganisations on the stock market. The success of these companies is partially possible by their characteristics of being a digital platforms. One of the success factors is the use open APIs, which makes that other partie

Due to globalization, increasing amounts of water are traded across borders as virtual water embodied in traded products. The thesis traces global water trade patterns at different levels of income between 1990 and 2015 in order to test whether developed countries outsource their water-intensive production to less developed countries increasing global water use in the process. The research problem