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BACKGROUND: Lichens, which represent symbiotic associations of fungi and algae, are potential sources of numerous natural products. Physciosporin (PHY) is a potent secondary metabolite found in lichens and was recently reported to inhibit the motility of lung cancer cells via novel mechanisms.PURPOSE: The present study investigated the anticancer potential of PHY on colorectal cancer (CRC) cells.M
Harvesting whole-tree biomass for biofuel combustion intensifies removal of nutrients from the ecosystem. This can be partly abated by applying ash from the combustion back to the system, as the ash is rich in nutrients. Ash is very alkaline and ash application raises soil pH, which in turn can stimulate microbial activity and thus decomposition and mineralization. Our aim was to test if ash induc
Climate change and its associated challenges may have an impact on people and communities. Studies provide conceptual and empirical insight of the relationship between social capital and resilience. However, the social dimensions of resilience have received little attention in climate change research. This short article provides a rapid review of published studies that investigate the social dimen
Context: Rapid growth has been suggested to promote islet autoimmunity and progression to type 1 diabetes (T1D). Childhood growth has not been analyzed separately from the infant growth period in most previous studies, but it may have distinct features due to differences between the stages of development. Objective: We aimed to analyze the association of childhood growth with development of islet
BACKGROUND. Neoantigen-driven recognition and T cell–mediated killing contribute to tumor clearance following adoptive cell therapy (ACT) with tumor-infiltrating lymphocytes (TILs). Yet how diversity, frequency, and persistence of expanded neoepitope-specific CD8+ T cells derived from TIL infusion products affect patient outcome is not fully determined. METHODS. Using barcoded pMHC multimers, we p
BACKGROUND: Peritoneal carcinomatosis in the absence of distant metastasis occurs in approximately 8 per cent of patients with colorectal cancer. Cytoreduction followed by hyperthermic intraperitoneal chemotherapy (HIPEC) is a new treatment option. Patient selection is crucial to outcome.METHODS: Cytoreduction followed by HIPEC was performed in 102 patients with peritoneal carcinomatosis. The foll
Background and purpose: To determine the prevalence of vertebral hemangiomas (VHs), establish a new classification of VHs based on their MRI-signal pattern, and study their natural history. Methods: MRI of 1000 consecutive patients who underwent at least two MRI with an interval of at least 3 years. Growth rate and change of MRI-signal pattern during the follow-up period were the parameters includ
OBJECTIVE: To compare experts' perceived usefulness of audit filters from Ghana, Cameroon, WHO and those locally developed; generate context-appropriate audit filters for trauma care in selected hospitals in urban India; and explore characteristics of audit filters that correlate to perceived usefulness.DESIGN: A mixed-methods approach using a multicentre online Delphi technique.SETTING: Two large
Objective: To determine whether a tight control (TC) regime with monthly consultations to the physician for the first 6 months, could increase remission rate and improve reported pain of patients with early rheumatoid arthritis (RA). Methods: In this single-centre, TC study, with monthly visits to the physician, a cohort of 100 patients with early RA was consecutively included. They were compared
Hybridization can result in novel allelic combinations which can impact the hybrid phenotype through changes in gene expression. While misexpression in F1 hybrids is well documented, how gene expression evolves in stabilized hybrid taxa remains an open question. As gene expression evolves in a stabilizing manner, break-up of co-evolved cis- and trans-regulatory elements could lead to transgressive
While prenatal exposure to ambient air pollution has been shown to be associated with reduced birth weight, there is substantial heterogeneity across studies, and few epidemiological studies have utilized source-specific exposure data. The aim of the present study was, therefore, to investigate the associations between local, source-specific exposure to fine particulate matter (PM2.5) during pregn
Pond water is used in everyday life by many people in Bangladesh, however, without sufficient and reliable information regarding water quality and pollution status. For this reason, geospatial analysis and mapping of water quality indices such as metal (MI), contamination (Cd), and physicochemical water quality index (WQI) were assessed to improve the understanding of potential pollution sources.
OBJECTIVE: To predict clinical outcome by classification of peritoneal metastases (PM) of colorectal or appendiceal origin.BACKGROUND: This study investigates whether standardized histological classification can predict outcome for PM of colorectal or appendiceal origin treated with cytoreduction and hyperthermic intraperitoneal chemotherapy (HIPEC).METHODS: Histology of PM (n = 269) was evaluated
An estimated 6% of human greenhouse gas emissions are the result of enteric methane production by cows. Asparagopsis taxiformis, a semi-tropical alga, is one solution. Supplementation of this alga to cows at a small percentage of their daily intake has reduced methane emissions by over 98% in trials. This success has led to multiple commercialization attempts globally, although no Asparagopsis tax
Homework is widely used in most schools across the world to complement classroom teaching, increase knowledge retention, and foster good study habits. The research on the effect of homework assignment on student achievement is, however, inconclusive with earlier research indicating a positive relationship and newer studies giving a more nuanced picture. This thesis uses data from the 2019 wave of
This comparative document analysis looks at the governmentality of the Finnish labor market policies (LMP’s). This study compares Sipilä’s and Marin’s government programs to see if there are differences. The focus is on depicting neoliberalization and power relations in the policies while investigating the framing of unemployment. The theoretical framework consists of the theory of neoliberal turn
The purpose of this study is to investigate how women with an ADHD diagnosis, who were diagnosed in the ages between 12-17, see their own experiences and identities in relation to role expectations of females. The ambition is to bring light to the stories of women, who have been in the shadow of the stereotypical ADHD man in society as well as in studies. The method chosen for empirical material i
Lactobacillus reuteri is known as probiotics with health benefits. Freeze-drying is frequently used to preserve probiotics and keep them alive. However, freeze-drying through freezing and drying might cause some damages to the probiotic’s cells. Formulation by protective agents including cryoprotectants and lyoprotectants prior to freeze-drying can prevent and reduce these damages. In this study,
Predictive archaeological modelling is a complex analytical process that requires the understanding of how complex environmental and anthropogenic spatial phenomena relate to the selection of archaeological site location and knowledge of the requirements and potential biases inherent in the method of modelling and the raw data itself. This paper aims to demonstrate the utility of the weights of ev
Mental illness has increasingly become a problem throughout the world and is believed to cost the global economy $16 trillion by 2030. Consequently, a growing body of literature investigates the possible causes of mental illness and more specifically, possible early life circumstances which may affect adult mental health. Limited research exists though in terms of exposure to recessions in utero a
