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Cladribine has single-drug activity in acute myeloid leukaemia (AML), and may enhance the formation of the active metabolite (ara-CTP) of cytosine arabinoside (ara-C). To evaluate the feasibility of adding intermittent cladribine to intermediate-dose ara-C (1 g/m(2)/2 h) b.i.d. for 4 d with idarubicin (CCI), we performed a 2:1 randomized phase II trial in AML patients aged over 60 years. Primary e
To prospectively study the prevalence of Lyme arthritis, 100 consecutive patients referred to a rheumatology out-patient clinic and 115 patients with a classified rheumatological disease were included. Individuals seropositive for antibody against the Borrelia burgdorferi sensu lato complex were examined for clinical signs or a history of Lyme borreliosis. Positive titres against B. burgdorferi s.
Hypothermia has been reported to reduce infarct size (IS) in patients with ST segment elevation myocardial infarction (STEMI). We aimed to confirm the cardioprotective effects of hypothermia using a combination of cold saline and endovascular cooling.
Background: Predicting future Alzheimer’s disease (AD)-related cognitive decline among individuals with subjective cognitive decline (SCD) or mild cognitive impairment (MCI) is an important task for healthcare. Structural brain imaging as measured by magnetic resonance imaging (MRI) could potentially contribute when making such predictions. It is unclear if the predictive performance of MRI can be
The nitrogen (N) cycle is a familiar concept. As is the much simplified, often diagrammatic, representation commonly used to illustrate the scale, importance and interconnectedness of this global cycle that links air, water, rocks and living beings. However, in this representation, humans are often presented as a seemingly minor entity or not explicitly shown at all. This can obscure the idea that
This paper presents a search for pair production of higgsinos, the supersymmetric partners of the Higgs bosons, in scenarios with gauge-mediated supersymmetry breaking. Each higgsino is assumed to decay into a Higgs boson and a nearly massless gravitino. The search targets events where each Higgs boson decays into Formula Presented, leading to a reconstructed final state with at least three energe
A search for charged-lepton-flavor violating Formula Presented (Formula Presented, Formula Presented) interactions is presented, considering both top-quark production and decay. The data analyzed correspond to Formula Presented of proton-proton collisions at a center-of-mass energy of Formula Presented recorded with the ATLAS detector at the Large Hadron Collider. The analysis targets events conta
In response to a period of low inflation and near-zero interest rates, the Swedish central bank initiated Quantitative Easing (QE) in 2015. While the impact of QE on bank lending has been studied in the US and UK, its effects in Sweden remains under-researched. We study the effects of QE on residential bank lending in Sweden through the liquidity, bank lending and bank capital channels. Using a on
Ghana and Kenya have both made significant efforts to strengthen the skills profile of their young and growing workforces. Raising skill levels and matching workers correctly to jobs is believed to increase productivity and reduce unemployment. The purpose of this thesis is to explore the skills potential within the urban workforces of Ghana and Kenya using data from the Skills Towards Employment
Coloniality persistently prevails in the many aspects of today’s societies, including identity constructions. However, the role of the Nordic region in colonialism and its continuous consequences has been severely downplayed, if not ignored, not least in connection to Finland. Thus, this research explores the visibilities of coloniality in social identity constructions in the context of Finland. A
The infraorder Ceratopsia, or horned dinosaurs, within the clade Dinosauria, shows a specific, restrained migratory pattern. Therefore, the classical view presented by Sereno (1999), of a monodirectal migratory event from Asia to North America via the Bering’s Strait has been commonly accepted in its simplicity. Another hypothe-sis presented during the same time by Chinnery (1998) suggests a migra
The aim of this study was to understand and explain which social and structural risk factors are behind young people choosing to commit criminal acts, in order to increase awareness of the problem. The method that was selected in this study was a qualitative method based on autobiographies and biographies. Four different autobiographies were used as empirical evidence and the analysis of the autob
Chronic wounds are an emerging healthcare issue and current methods of healing chronic wounds address bacteria but are ineffective against resistant bacteria and the biofilm formation commonly observed in these wounds. Antimicrobial peptides (AMPs) derived from the endogenous wound healing system have been shown to combat bacterial infections, exhibit immunomodulatory effects, as well as improvi
In this thesis an optimization of a previously performed inclusive search for beyond Standard Model Physics in same-sign di-lepton final states is performed, but tuned for a doubly-charged Higgs boson decaying to same-sign di-muons. The doubly-charged Higgs boson is a proposed fundamental particle whose existence would provide evidence for theoretical extensions of the Standard Model (SM) of parti
Plant functional traits are fundamental to ecosystem dynamics and Earth system processes, but their global characterization is limited by available field surveys and trait measurements. Recent expansions in biodiversity data aggregation—including vegetation surveys, citizen science observations, and trait measurements—offer new opportunities to overcome these constraints. Here we demonstrate that
Groundwater-dependent vegetation (GDV) plays a vital role in maintaining biodiversity and ecosystem services in the Mediterranean biome but is increasingly threatened by climate and land use change. Large-scale GDV mapping in arid regions is critical for effective conservation and water resource management but remains challenging due to limited ground-truth data and the lack of high-resolution rem
In urban growth modeling methods, researchers typically determine an appropriate scale based on various factors such as the extent of the study area, the scale of available data, and the level of detail required. With rapid urbanization, cities and towns have grown dramatically, leading to the emergence of numerous megalopolitan areas worldwide. In these areas, which include small and large cities
The search for predictors of plant diversity has challenged scientists for decades. Here we identify intense photosynthetically active radiation (PAR) as a major factor constraining plant species richness in global grasslands. We show that the strength of the negative relationship between species richness and PAR increases with increasing elevation and that species richness is more strongly correl
