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Systemic lupus erythematosus (SLE) is a severe autoimmune connective tissue disease. Our current knowledge about the serum proteome, or serum biomarker panels, reflecting disease and disease status is still very limited. Affinity proteomics, represented by recombinant antibody arrays, is a novel, multiplex technology for high-throughput protein expression profiling of crude serum proteomes in a hi
We have designed a new class of microdevices composed of a supporting plastic (polyvinyl chloride, PVC) plate integrated with a groove for a piece of fused silica capillary (the separation channel), a slit for on-tube detection, an “islet” for the application of sample, electrode vessels and platinum electrodes. The design permits electrophoretic, electrochromatographic and chromatographic separat
Completely homogeneous polyacrylamide-based gels were used for capillary electrochromatography (CEC) of drug enantiomers. Like continuous beds (also called continuous polymer rods, silica rods, monoliths) they do not require frits to support the bed, because it is covalently linked to the capillary wall. Along lifetime is an important feature of the beds. The gel matrices can be prepared in any la
A devastating complication associated with negative-pressure wound therapy (NPWT) after cardiac surgical intervention is heart rupture resulting in serious bleeding. The benefit of a rigid barrier between the underlying organs and the sharp sternal edges has been demonstrated in pigs. In the present article, we present our first 6 patients with deep sternal wound infection treated with NPWT in com
This paper deals with a single-echelon inventory system consisting of a number of parallel local warehouses facing compound Poisson demand. There are standard holding and backorder costs as well as ordering costs at all warehouses. Normally, the warehouses replenish from an outside supplier. However, lateral transshipments between the warehouses are also possible. Such transshipments take no time
The Cochrun-Grabel (C-G) method, an algorithm for finding the characteristic polynomial of a circuit containing reactances, has so far been restricted to circuits not employing mutual inductances. In this paper we present an intuitive, yet rigorous, proof of the Cochrun-Grabel method for a general RLC circuit, and we extend the method to allow the analysis of an RLC circuit containing mutual induc
A differential two-wire communication link with a 3-level asynchronous protocol is introduced. The proposed 3-level code contains information of both data and clock. Since only one edge is needed for each bit, the bandwidth of a link is efficiently utilized. The power consumption is reduced by the low-swing differential two-wire link and is further reduced by a 3-level code. The speed of the proto
I arbete och umgänge med människor med någon form av kognitivt funktionshinder har bilder och symboler använts länge. Syftet med denna rapport om digitala bilders betydelse för personer med kognitiva funktionshinder är att visa på att det finns en utbredd användning av digitala bilder inom skola, vård och omsorg, och att det finns mycket kunnande inom området. Jag hoppas också att rapporten ska tj
Functioning of the immune system requires the coordinated expression and action of many genes and proteins. With the emergence of high-throughput technologies, a great amount of molecular data is available for the genes and proteins of the immune system. However, these data are scattered into several databases and literature and therefore integration is needed.
Objective Nocturnal gastroesophageal reflux (nGER) has been associated with respiratory diseases. Our aim was to study a questionnaire method to identify nGER subjects with respiratory involvement in a general population. Material and methods A subgroup of Icelandic participants in the European Community Respiratory Health Survey III (ECRHS III) reporting symptoms of nGER (n = 48) as well as age a
A new type of chip based microelectrode for acute electrophysiological recordings in the CNS has been developed. It's designed to be adaptable to a multitude of specific neuronal environments, in this study the cerebellar cortex of rat and cat. Photolithographically patternened SU-8 is used to yield flexible and biocompatible penetrating shanks with gold leads. Electrodes with an impedance of abou
Pancreatic cystic neoplasms are detected at an increasing frequency due to an increased use and quality of abdominal imaging. There are well known differential diagnostic difficulties concerning these lesions. The aim is to review current literature on the diagnostic options and the following treatment for cystic lesions in the pancreas focusing on serous cystadenomas, primary mucinous neoplasm of
The language on Swedish rune stones written in the 16 character alphabet (futhark) constitutes a very special fragment of the Swedish of its time (about 800-1100). Because of the ritual character of the inscriptions the language is rather standardized. The greatest variation is in proper names. As has long been noted the typical formula is (in English translation): N raised this stone after M his
In this paper we extend the eliminant construction of Burchnall and Chaundy for commuting differential operators in the Heisenberg algebra to the q-deformed Heisenberg algebra and show that it again provides annihilating curves for commuting elements, provided q satisfies a natural condition. As a side result we obtain estimates on the dimensions of the eigenspaces of elements of this algebra in i
During the next three to five years, the municipality of Palanga will make a number of crucial development decisions that will have significant longterm impacts on the lives of its citizens. Because Palanga is a beautiful region whose largely unspoiled natural resources attract many tourists, it is critical that these decisions be made with a view towards environmental sustainability so as not to
