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Individual patient data meta-analysis of trials investigating the effectiveness of intra-articular glucocorticoid injections in patients with knee or hip osteoarthritis : an OA Trial Bank protocol for a systematic review.

Based on small to moderate effect sizes for the wide range of symptomatic treatments in osteoarthritis (OA), and on the heterogeneity of OA patients, treatment guidelines for OA have stressed the need for research on clinical predictors of response to different treatments. A meta-analysis to quantify the effect modified by the predictors using individual patient data (IPD) is suggested. The initia

Theory of Random Matrices and Elasticity Applied to Nanowires and Mechanical Vibrations

This thesis presents work in several areas relating to Random Matrix Theory and Elasticity. It contains 4 papers presenting work on different issues. Paper I concerns correlations between eigenvalues in random matrices of real symmetric (GOE) or quaternion real (GSE) form. It presents a calculation showing that correlations between arbitrarily many eigenvalues can be obtained from averages of a t

Development of Second and Third Generation Bioelectronics

The field of research dealing with the integration of biomolecules with electronic elements to form functional devices is called ‘‘bioelectronics’’. Bioelectronics based on mediated electron transfer (MET) between the biological element and the electrodes are designated as “second generation” while the one based on direct electron transfer (DET) is specified as “third generation”. Implanted bioele

Epidemiology of intra- and peri-articular structural injuries in traumatic knee joint hemarthrosis – data from 1145 consecutive knees with subacute MRI

Objective In patients with traumatic knee distorsion and hemarthrosis, to investigate the panorama of structural injury, as visualized on magnetic resonance imaging (MRI). Design Cohort study of 1145 consecutive patients with traumatic knee distorsion who underwent MRI within median 8 days after injury. We present structural injury as visualized on MRI in relation to age, sex and activity at injur

Tailoring the internal structure of liquid crystalline nanoparticles responsive to fungal lipases : A potential platform for sustained drug release

Lipases are key components in the mechanisms underlying the persistence and virulence of infections by fungi, and thus also promising triggers for bioresponsive lipid-based liquid crystalline nanoparticles. We here propose a platform in which only a minor component of the formulation is susceptible to cleavage by lipase and where hydrolysis triggers a controlled phase transition within the nanopar