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Redefining passivity breakdown of super duplex stainless steel by electrochemical operando synchrotron near surface X-ray analyses

Passivity determines corrosion resistance and stability of highly-alloyed stainless steels, and passivity breakdown is commonly believed to occur at a fixed potential due to formation and dissolution of Cr(VI) species. In this work, the study of a 25Cr–7Ni super duplex stainless steel in 1 M NaCl solution revealed that the passivity breakdown is a continuous degradation progress of the passive fil

Research on thermal properties of novel silica nanoparticle/binary nitrate/expanded graphite composite heat storage blocks

In order to study the effects of EG (expanded graphite) content and SiO2 nanoparticles on the specific heat and thermal conductivity of nano-SiO2/NaNO3–KNO3/EG composite heat storage materials, a series of nano-SiO2/NaNO3–KNO3/EG composites are prepared by the aqueous solution-ultrasound oscillation method. The nano-SiO2/NaNO3–KNO3 and EG with different mass fractions (5%, 10%, 15% and 20%) are us

Recent-onset atrial fibrillation: challenges and opportunities

Atrial fibrillation (AF) is increasingly diagnosed early, close to its first occurrence due to: (i) increased public awareness with self-screening; (ii) health care initiatives including population screening and opportunistic case finding; and (iii) increased use and surveillance of implantable cardiac devices. At its onset, AF is often low burden, and cardiovascular co-morbidities may be absent o

Evaluation of a Novel Automated Cerebral Ventricular Drainage System for Intracranial Pressure Monitoring and Cerebrospinal Fluid Drainage in Neurocritical Care Patients : A Prospective, Randomized Clinical Study

BACKGROUND: Neurointensive care is moving toward more automated patient management. This study aimed to evaluate a novel external ventricular drainage (EVD) system, the VGuard® system, as a tool for intracranial pressure (ICP) monitoring and automating ventricular drainage of cerebrospinal fluid (CSF), focusing on its safety and potential to reduce complications associated with manual EVD manageme

Body mass index and subsequent fracture risk: a meta-analysis to update FRAX

The aim of this international meta-analysis was to quantify the predictive value of BMI for incident fracture and relationship of this risk with age, sex, follow-up time, and BMD. A total of 1667922 men and women from 32 countries (63 cohorts), followed for a total of 16.0 million person-years were studied. 293325 had FN BMD measured (2.2 million person-years follow-up). An extended Poisson model

A meta-analysis of smoking and fracture risk to update the FRAX® tool

Summary: In this meta-analysis of international cohorts, current smoking is confirmed as a significant BMD-independent predictor of future fracture with a stronger relationship in men than in women. A causative and reversible effect of smoking on fracture risk is suggested by past smoking having a significantly lower risk than current smoking. Purpose: In this meta-analysis of international cohort

A conceptual health economic modelling framework to assess the cost-effectivenesof molecular target–driven treatment regimens in oncology

Background and purpose: Molecularly targeted cancer therapies challenge conventional health economic evaluation frameworks that are structured around tumour-specific indications, comparators, and trial designs. Existing models often rely on pooled estimates from heterogeneous early-phase evidence or single-indication analyses, creating uncertainty for reimbursement decision-makers. We propose a co

Effectiveness of behaviour change interventions to reduce the risk of faecal contamination in urban irrigated vegetable value chains – applying the COM-B behavioural framework

In low-and middle-income countries, inadequate sanitation results in faecal contamination of the water used by urban farmers for irrigation. Consumers of raw contaminated vegetables run the risk of developing diarrhoeal diseases and helminth infections, which are a leading cause of under-five mortality and impact the well-being and productivity of millions of adults. This review identifies the evi

Unplanned intensive care unit admission after elective colon cancer resection : population-based registry study

Background: The incidence, aetiology, and outcome of unplanned intensive care unit admission after elective colon cancer surgery remain unclear. This study investigated the incidence of, and factors associated with, unplanned intensive care unit admission following elective colon cancer resection in Sweden. Methods: This nationwide retrospective registry study included adult patients undergoing el

Confronting mortality : A meta-analysis and systematic review of psychedelic experiences and death anxiety

This meta-analysis and systematic review examined the effects of psychedelic substances on death anxiety, specifically evaluating whether psychedelic experiences are associated with statistically significant reductions in death anxiety. A systematic search identified 8 studies suitable for meta-analysis and 10 additional studies for systematic review. Using a random-effects model, the meta-analysi

Reducing selection bias while maintaining precision through an integrated analysis : 2-year longitudinal analysis of imaging outcomes in the SPondyloArthritis Caught Early cohort

Background: Cohort studies often use simple models, for example, completers-only or aggregated scores, to assess changes in imaging outcomes. With more data available, this introduces selection bias. Integrated analyses allow scores from multiple reading rounds; therefore, we assessed their effect on the change estimates’ precision compared with the completers-only analysis. Second, we compared ch

Can tests of physical fitness predict traumatic knee injury in youth female athletes? A prospective cohort study

Objectives To compile a battery of test including various aspects of physical fitness that could be used on the field and to assess whether any of these tests are associated with future traumatic knee injuries in youth female team sports athletes. Design Prospective cohort. Setting Sport setting. Participants Female athletes (n = 117, age 15–19 years), from Swedish sport high schools, active in so

Bringing the edges to the core

When a course is designed, it is common to do it for a typical group of students, considered to represent “the majority”, the “norm” or the “average”. The concept of “edges” challenges this view: given the multiple dimensions that teaching and learning encompass, there will always be students who do not belong to a norm and will end up on an edge if they are not included in the course design. In t

Higher HIV-1 evolutionary rate is associated with cytotoxic T lymphocyte escape mutations in infants

Escape from cytotoxic T lymphocyte (CTL) responses toward HIV-1 Gag and Nef has been associated with reduced control of HIV-1 replication in adults. However, less is known about CTL-driven immune selection in infants as longitudinal studies of infants are limited. Here, 1,210 gag and 1,264 nef sequences longitudinally collected within 15 months after birth from 14 HIV-1 perinatally infected infant

Circulating Interleukin 17A and Other Inflammatory Proteins May Predict Cardiovascular Disease in Early Rheumatoid Arthritis

Objective. The objective of this study was to investigate the impact of 92 inflammatory proteins on the risk of cardiovascular disease (CVD) in patients with early rheumatoid arthritis (RA). Methods. This study included consecutive patients with early RA recruited between 1995 and 2002. Stored plasma samples were analyzed for 92 inflammatory proteins. CVD diagnoses were retrieved from national in-