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Objective: To determine the independent impact of different definitions of remission and low disease activity (LDA) on damage accrual. Methods: Patients with ≥2 annual assessments from a longitudinal multinational inception lupus cohort were studied. Five mutually exclusive disease activity states were defined: remission off-treatment: clinical Systemic Lupus Erythematosus Disease Activity Index (

Background: Smartwatches are commonly capable to record a lead-I-like electrocardiogram (ECG) and perform a photoplethysmography (PPG)-based atrial fibrillation (AF) detection. Wearable technologies repeatedly face the challenge of frequent premature beats, particularly in target populations for screening of AF. Objective: To investigate the potential diagnostic benefit of six-lead ECG compared to

Activities for deep tissue imaging and photoactivation will be presented. Wihin Biophotonics@Tyndall projects based on upconverting nanoparticles and ultrasound optical tomography will be pursued. Data from collaborative research will be given.

Wintering energy management in small passerines has focused on the adaptive regulation of the daily acquisition of energy reserves within a starvation-predation trade-off framework. However, the possibility that the energetic cost of living, i.e. basal metabolic rate (BMR), is being modulated as part of the management energy strategy has been largely neglected. Here, we addressed this possibility

BACKGROUND. The reported prevalence of serious bacterial infections (SBI: urinary tract infection (UTI), bacteremia, and meningitis) among febrile infants ≤60 days of age varies from 8% to 23%. There are indications that the prevalence of infections differs between the sexes. Infants with fever at home but afebrile at the pediatric emergency department (PED) might have a lower risk of SBIs. Furthe

IntroductionInjury prevention training is effective in reducing injuries in youth team sports, but public health impact is limited because such training is not widely, properly, or sustainably implemented. Insufficient involvement of end-users has been identified as a main barrier to implementation. Based on results from previous studies within the I-PROTECT project, the aim was to develop a full

Shuker points to some inconsistencies in my terminology about consequence laws in evolutionary biology, specifically that gene flow and recombination are not as easily classified as one gets the impression of after reading Sober (1984). I agree, and I also emphasize that evolutionary biology should not only focus on consequence laws, but also source laws arising from the ecological selective envir

Introduction: In factor VIII (FVIII) prophylaxis for haemophilia A, cost comparisons have used price per international unit (IU) based on the once reasonable assumption of equivalent outcome per IU. Now, with several extended half-life (EHL) products available, new outcome-oriented ways to compare products are needed. Area under the curve (AUC) quantifies FVIII levels over time after infusion prov

Background: Adolescence is associated with different feelings and experiences that can negatively affect adolescents’ health and well-being. In the transition between childhood and adulthood, experiences of loneliness are common. A deep form of loneliness is described as existential loneliness. Studies among adults have shown that existential loneliness often arises in connection with transitions

AimTo describe child health care nurses' experiences of teaching infant massage in parent groups.DesignThis was an exploratory-descriptive qualitative study based on individual interviews.MethodQualitative semi-structured interviews were conducted with child health care nurses (N = 9) according to the COREQ guidelines and analyzed with qualitative content analysis.ResultsFive categories were ident

Background: Informal caregivers may experience high levels burden. Prior to COVID-19, loneliness and social isolation, and especially the discordance between them, were recognized for rapid aging-related cognitive decline. The COVID-19 has significantly increased social isolation and loneliness in caregivers. Thus, we aimed to explore the variables that were associated with higher care burden amon

Background: The COVID-19 pandemic has renewed attention to the conflicting demands placed on caregivers worldwide. Nowhere is this more evident than in South Asia, where cultural norms and a scarcity of long-term care facilities have made the home the locus of caregiving for individuals with brain health conditions and disabilities. A hidden cost of this informal arrangement is the burden experien

OBJECTIVES: To evaluate how radiographic damage, overall and measured as joint space narrowing score (JSNS) and erosion score (ES), as well as other clinical and laboratory measures, relate to disability and pain in early rheumatoid arthritis (RA).METHODS: An inception cohort of 233 patients with early RA, recruited in 1995-2005, was followed for 5 years. Disability was assessed with the Health As

An Integrated Selective Enrichment Target (ISET), microfabricated for efficient on-bead enzymatic digestion of proteins compatible for a direct interface with matrix-assisted laser desorption /ionization mass spectrometry (MALDI MS) is presented.

Background: The Nordic Nutrition Recommendations (NNR) are developed to promote public health and to prevent food-related diseases such as obesity and cardiovascular diseases. Objective: To investigate the nutrient intake and adherence to the NNR in a Swedish cohort with abdominal obesity. Design: Dietary intake data were collected using 3-day food diaries and anthropometry and clinical chemistry

The objective of this article was to assess the cost-effectiveness of screening strategies for cardiovascular diseases (CVD). A decision analytic model was constructed to estimate the costs and benefits of one-off screening strategies differentiated by screening age, sex and the threshold for initiating statin therapy (“uniform” or “age-adjusted”) from the Spanish NHS perspective. The age-adjusted

OBJECTIVES: A growing body of evidence links age related brain pathologies to systemic vascular processes. We aimed to study the prevalence and interrelations between magnetic resonance imaging (MRI) markers of cerebral small vessel disease and patterns of brain atrophy, and their association to carotid duplex ultrasound flow parameters.MATERIALS AND METHODS: We investigated a population based ran