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In this study, we present integrated quantitative proteome, transcriptome, and methylome analyses of hematopoietic stem cells (HSCs) and four multipotent progenitor (MPP) populations. From the characterization of more than 6,000 proteins, 27,000 transcripts, and 15,000 differentially methylated regions (DMRs), we identified coordinated changes associated with early differentiation steps. DMRs show

Infections are associated with extensive platelet consumption, representing a high risk for health. However, the mechanism coordinating the rapid regeneration of the platelet pool during such stress conditions remains unclear. Here, we report that the phenotypic hematopoietic stem cell (HSC) compartment contains stem-like megakaryocyte-committed progenitors (SL-MkPs), a cell population that shares

Regulatory T cells (Tregs) differentiate in the thymus, but the mechanisms that control this process are not fully understood. We generated a comprehensive quantitative and differential proteome of murine Tregs and conventional T cells. We identified 5225 proteins, 164 of which were differentially expressed in Tregs. Together with the comparative analysis of proteome and gene expression data, we i

Hematopoietic stem cells possess lifelong self-renewal activity and generate multipotent progenitors that differentiate into lineage-committed and subsequently mature cells. We present a comparative transcriptome analysis of ex vivo isolated mouse multipotent hematopoietic stem/progenitor cells (Lin(neg)SCA-1(+)c-KIT(+)) and myeloid committed precursors (Lin(neg)SCA-1(neg)c-KIT(+)). Our data displ

The field of proteomics is progressing at a rapid pace, developing from primarily a specialist technology to a valuable tool in biological research. Importantly, the establishment of mass spectrometry as a quantitative method, miniaturisation of liquid chromatography techniques, and improved sensitivity of mass-spectrometric instrumentation now enable near-complete monitoring of cellular proteome

The concepts of target efficiency can be used to assess the extent to which service provision is in line with the needs of the population. Horizontaltarget efficiency denotes the extent to which those deemed to need a service receive it and vertical target efficiency is the corresponding extent to which those who receive services actually need them. The aim of this study was to assess the target e

Objectives: Heterophilic antibodies, such as rheumatoid factor (RF), are known to interfere with enzyme-linked immunosorbent assays (ELISAs). Treatment of rheumatoid arthritis (RA) with tumour necrosis factor (TNF)-α blockers is well established. The aims of this study were to develop a protocol for blocking the interaction of present heterophilic antibodies and to validate this procedure by evalu

We demonstrate improved performance due to enhanced electrostatic control achieved by diameter scaling and gate placement in vertical InAs-GaSb tunneling field-effect transistors integrated on Si substrates. The best subthreshold swing, 68 mV/decade at VDS=0.3 V, was achieved for a device with 20-nm InAs diamter. The on-current for the same device was 35 µA/µm at VGS=0.5 V and VDS=0.5 V. The fabri

Noncoding RNAs control critical cellular processes, although their contribution to disease remains largely unexplored. Dyskerin associates with hundreds of H/ACA small RNAs to generate a multitude of functionally distinct ribonucleoproteins (RNPs). The DKC1 gene, encoding dyskerin, is mutated in the multisystem disorder X-linked dyskeratosis congenita (X-DC). A central question is whether DKC1 mut

How pseudouridylation (Ψ), the most common and evolutionarily conserved modification of rRNA, regulates ribosome activity is poorly understood. Medically, Ψ is important because the rRNA Ψ synthase, DKC1, is mutated in X-linked dyskeratosis congenita (X-DC) and Hoyeraal-Hreidarsson (HH) syndrome. Here, we characterize ribosomes isolated from a yeast strain in which Cbf5p, the yeast homolog of DKC1

Mutations in DKC1, encoding for dyskerin, a pseudouridine synthase that modifies rRNA and regulates telomerase activity, are associated with ribosomal dysfunction and increased cancer susceptibility in the human syndrome, X-linked dyskeratosis congenita (X-DC). In a mouse model for X-DC, impairments in DKC1 function affected the translation of specific mRNAs harboring internal ribosomal entry site

Defects in ribosome biogenesis and function are present in a growing list of human syndromes associated with cancer susceptibility. One example is X-linked dyskeratosis congenita (X-DC) in which the DKC1 gene, encoding for an enzyme that modifies ribosomal RNA, is found to be mutated. How ribosome dysfunction leads to cancer remains poorly understood. A critical cellular response that counteracts

Microsoft Word - Växternas evolution.intro.docx Växternas evolution Mångfalden av växter i Botaniska trädgården ger goda möjligheter att undersöka hur olika växtgrupper och enskilda arter har anpassat sig efter sina livsmiljöer och samspel med andra organismer. Längd: ca 45 minuter Max antal elever: 15 Pris: 300 kr Misteln är en slags parasit som växer uppe i träd. Den kan inte växa på marken. Hur

https://www.botan.lu.se/sites/botan.lu.se/files/vaxternas_evolution.intro_.pdf - 2026-06-07

Proposal Guidelines 2018 Call 2 EIT Climate-KIC 1 PROPOSAL GUIDELINES EIT BUSINESS PLAN 2018 Call 2 Deadline for Application: 2nd March 2018 Covering Earlier-Stage Innovation: Pathfinder and Partner Accelerator Later-Stage Innovation: Demonstrator, Scaler, and Urban Challenges Other Innovation: Climate Innovation Ecosystems Education: Online Education and Professional Education Publication Date: 1

https://www.climate-kic.lu.se/sites/climate-kic.lu.se/files/proposal_guidelines_2018_call_2_v1-12.pdf - 2026-06-07

Microsoft Word - Afrint II Zambia micro report_draft.doc i INSTITUTE OF ECONOMIC AND SOCIAL RESEARCH University of Zambia AFRINTII –THE MILLENUIM DEVELOPMENT GOALS AND THE AFRICAN FOOD CRISIS ZERO DRAFT MICRO REPORT MAY 2009 ii TABLE OF CONTENTS iii LIST OF TABLES iv LIST OF ACRONYMS v ACKNOWLEDGEMENTS The study AFRINTII-The Millennium Development Goals and the African Food Crisis has been prepare

https://www.keg.lu.se/en/sites/keg.lu.se.en/files/a28.pdf - 2026-06-07

Riktlinjer kurs vs annat poänggivande moment                 Postadress Kansli N, Box 118, 221 00 Lund Besöksadress Astronomihuset, Sölvegatan 27 Telefon 046-2228213, 046-222 00 00 E-post Tobias.Nilsson@science.lu.se Internet http://www.naturvetenskap.lu.se Riktlinjer för vad som ska anses vara en kurs och vad som ska anses vara ett ”annat poänggivande moment” Utöver avhandlingsarbetet kan poäng i

https://www.naturvetenskap.lu.se/internt/sites/naturvetenskap.lu.se.internt/files/riktlinjer_kurs_vs_annat_moment.pdf - 2026-06-07