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Objective: Interstitial lung disease (ILD) can occur in association with antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV-ILD) or as an isolated entity with positive ANCA (ANCA-ILD). However, data on the epidemiology and outcomes of these conditions remain limited. Methods: A European multicenter retrospective study encompassed patients with AAV-ILD or ANCA-ILD. Baseline and s

Bacteria encode diverse defence systems, including restriction-modification and CRISPR-Cas, that cleave nucleic acid to protect against phage infection. Bioinformatic analyses demonstrate that many recently identified antiphage defence operons comprise a nuclease and NTPase protein, suggesting that additional nucleic acid-targeting systems remain to be understood. Here we develop large-scale compa

Long RSH enzymes, Rel and RelA, are master regulators of bacterial (p)ppGpp alarmones levels. Bifunctional Rel transitions between a compact hydrolysis-competent (HD ON) state, a relaxed catalytically inactive (HD OFF/SYNTH OFF) state, and an elongated synthesis-competent (SYNTH ON) state, whereas RelA samples only the latter two. The distribution of these states is controlled by starved ribosomes

BACKGROUND: The major pathways contributing to cardiovascular disease among night shift workers remain poorly understood. MicroRNAs (miRNAs) have been identified as novel regulators of cardiovascular risk factors. Our objective was to examine whether night shift work was associated with altered expression of five cardiovascular-related miRNAs in night and day shift workers.METHODS: RNA was extract

A set of ultrawide bandgap single-crystal NdGaO3 samples cut with crystallographic surface orientations (001), (101), and (110) are investigated by using generalized spectroscopic ellipsometry. We report the complex anisotropic dielectric functions in the spectral range from 0.73 to 9.0 eV, for polarization along directions a, b, and c of the orthorhombic unit cell. A Kramers–Kronig consistent par

We investigate the temperature-dependent complex dielectric function of bulk single-crystal In2O3 over the spectral range of 1–6 eV and temperatures from room temperature to 600 °C under high-vacuum conditions using in situ spectroscopic ellipsometry. The dielectric function was modeled using wavelength-by-wavelength and critical-point model dielectric function analyses. The dielectric function ex

Begreppet adaptation to the adverse effects of climate change är relativt nytt in internationell miljörätt. Begreppet adaptation är inte definierat i UNFCCC. Den här uppsatsen analyserar adaptation i ljuset av begreppet reparation i internationell sedvanerätt. Uppsatsen undersöker vad begreppen adaptation och reparation har gemensamt. Kan adaptation i UNFCCC ses som en möjlig utveckling eller förlThe concept of adaptation to the adverse effects of climate change is relatively recent in international environmental law. Adaptation is not defined in the UNFCCC. This paper attempts to address adaptation in the UNFCCC from the perspective of reparation under customary international law. It investigates what the concepts of adaptation and reparation have in common. Could adaptation in the UNFCCC

Objective: This study assessed a national healthcare intervention launched in Sweden in 2015 to reduce the time between macroscopic haematuria, diagnosis and treatment of urinary tract cancer. Methods: The outcome of the first 11 months was evaluated in 1697 individuals referred to a standardized care pathway for urinary tract cancer compared with 174 patients with conventionally diagnosed urothel

BackgroundWhile genome-wide association studies (GWAS) of multiple myeloma (MM) have identified variants at 23 regions influencing risk, the genes underlying these associations are largely unknown. To identify candidate causal genes at these regions and search for novel risk regions, we performed a multi-tissue transcriptome-wide association study (TWAS).ResultsGWAS data on 7319 MM cases and 234,3

Chronic sun-damaged (CSD) melanoma represents 10%-20% of cutaneous melanomas and is characterized by infrequent BRAF V600E mutations and high mutational load. However, the order of genetic events or the extent of intra-tumor heterogeneity (ITH) in CSDhigh melanoma is still unknown. Ultra-deep targeted sequencing of 40 cancer-associated genes was performed in 72 in situ or invasive CMM, including 2

Background: Sentinel node biopsy (SNB) is the standard procedure for axillary staging in patients with clinically lymph node negative invasive breast cancer. Completion axillary lymph node dissection (c-ALND) may not be necessary for all patients as a significant number of patients have no further metastases in non-sentinel nodes (non-SN) and c-ALND may not improve survival. The first aim of our s

OBJECTIVE: Because elevated copeptin, a marker of vasopressin, is linked to low water intake and high diabetes risk, we tested the effect of water supplementation on copeptin and fasting glucose.DESIGN, SETTING, AND PARTICIPANTS: Thirty-one healthy adults with high copeptin (>10.7 pmol · L-1 in men and >6.1 pmol·L-1 in women) identified in a population-based survey from 2013 to 2015 and with a cur

Background: Arterial stiffness is known to be associated with a number of clinical conditions including hypertension, diabetes and dyslipidemia, and may predict cardiovascular events and mortality. However, causal links are hard to establish. Results from genome-wide association studies have identified only a few single nucleotide polymorphisms associated with arterial stiffness, the results have

Background Identification of lifestyle modifiable metabolic pathways related to cardiometabolic disease risk is essential for improvement of primary prevention in susceptible individuals. It was recently shown that plasma dimethylguanidino valerate (DMGV) levels are associated with incident type 2 diabetes mellitus. Our aims were to investigate whether plasma DMGV is related to risk of future coro

Enrichment of rare cells from peripheral blood has emerged as a means to enable noninvasive diagnostics and development of personalized drugs, commonly associated with a prerequisite to concentrate the enriched rare cell population prior to molecular analysis or culture. However, common concentration by centrifugation has important limitations when processing low cell numbers. Here, we report on a