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We describe a novel method for determining weak association constants of oligomeric protein complexes formed transiently under equilibrium conditions. This type of equilibrium process is recognized as being biologically important, but generally hard to study. Heteronuclear spin relaxation rates measured at multiple protein concentrations are analyzed using relaxation rates predicted from hydrodyna
This study analysed the costs of median and ulnar nerve injuries in the forearm in humans and factors affecting such costs. The costs within the health-care sector and costs of lost production were calculated in 69 patients with an injury to the median and/or ulnar nerve in the forearm, usually caused by glass, a knife, or a razorblade. Factors associated with the variation in costs and outcome we
Mirtazapine pharmacokinctic (PK) data from patients on long-term treatment for major depression have never been investigated. For this reason, in a large naturalistic outpatient study (prospective, multicenter, open-labeled, and noncomparative) conducted in Sweden in the period 2000 2002, one of the main objectives was to outline the inter- as well as intraindividual PK variance of mirtazapine and
Conclusion. Our results show that average and poor oral hygiene and inadequate dental status are independent risk factors for oral and oropharyngeal squamous cell carcinoma ( OOSCC), irrespective of tobacco and alcohol consumption. Objective. To evaluate a possible relationship between oral cancer, oral hygiene, dental status, oral mucosal lesions and some lifestyle factors in a population- based
OBJECTIVE: To evaluate the long-term outcome of patients treated in the surgical intensive care unit (SICU) for abdominal sepsis. DESIGN: Retrospective study. SETTING: University hospital, Sweden. SUBJECTS: 210 consecutive patients treated for abdominal sepsis in the SICU at Lund University Hospital during the period January 1983 to December 1995. MAIN OUTCOME MEASURES: Background information, mor
PURPOSE: To report an interim analysis of the registry data and evaluate the performance of Trufill DCS Orbit coils in terms of the stability of initial aneurysmal occlusion. MATERIALS AND METHODS: From May 1, 2004, to February 1, 2006, 291 patients with ruptured or unruptured aneurysms were enrolled in a multiple-center global registry from 37 centers in the United States, Europe, and Latin Ameri
Two monoclonal antibodies (mAb) CB268 and CII-C1 to type 11 collagen (CII) react with precisely the same conformational epitope constituted by the residues ARGLT on the three chains of the CII triple helix. The antibodies share structural similarity, with most differences in the complementarity determining region 3 of the heavy chain (HCDR3). The fine reactivity of these mAbs was investigated by s
Under the growing influence of dominant discourses such as ecological modernisation and neo- liberalisation, proposed alternative conservation approaches focus more and more on efficiency. In the realm of biodiversity conservation, synthetic biology - the application of engineering to facilitate and accelerate the design or modification of genetic materials in living organisms – has emerged as an
While carbon emissions hit an all-time high in 2019 and are expected to grow, it is important to explore strategies for reducing emissions and mitigating climate change. A potential focus for curbing emissions is the flying sector, since air travel is one of the most carbon-intensive activities an individual can engage in. Among air travelers, frequent flyers yield the highest potential for saving
Many citizens in Ranchi, Jharkhand, suffer from the consequences of contaminated drinking water. The city’s water governance system therefore urgently needs to find ways to bring safe drinking water to its people. Prevalent models in water governance however do not provide effective guidance for the necessary transition process. They lack heuristics that facilitate an in-depth understanding of con
There have been several accounts of suicide attacks in the last few years; and although male attackers outnumber female attackers, the number of female suicide bombers has been on the rise. This thesis analyzes the motivation of Muslim female suicide bombers using Durkheim’s theory on suicide and society. Interviews with experts on suicide and radicalization were conducted to provide a perspective
Activation measures were implemented as a condition for social assistance in Sweden in the 1990s. Generally, the goal has been to promote the transition from welfare to work and to(re)integrate people dependent on social assistance into the labour market. Social assistance is regulated by the Social Services Act, which is a framework law that gives municipalities and individual social workers exte
Abstract: This thesis analyzes the distribution of profits to labor. The factor share distribution has attracted mounting attention from researchers in the last decades, as it has been identified as a central determining factor for economic inequality. However, how the factor share distribution has developed historically is debated. By analyzing the historical wage share for manufacturing workers
A search for the Higgs boson has been performed in the H -> WW(*()) -> l+vl-(v) over bar channel (l = e/mu) with an integrated luminosity of 2.05 fb(-1) of pp collisions at root s = 7 TeV collected with the ATLAS detector at the Large Hadron Collider. No significant excess of events over the expected background is observed and limits on the Higgs boson production cross section are derived for a Hi
A search is presented for direct chargino production based on a disappearing-track signature using 20.3 fb(-1) of proton-proton collisions at root s = 8 TeV collected with the ATLAS experiment at the LHC. In anomaly-mediated supersymmetry breaking (AMSB) models, the lightest chargino is nearly mass degenerate with the lightest neutralino and its lifetime is long enough to be detected in the tracki
The ability of von Willebrand factor (VWF) to bind platelet GP Ib and promote platelet plug formation is measured in vitro using the ristocetin cofactor (VWF:RCo) assay. Automated assay systems make testing more accessible for diagnosis, but do not necessarily improve sensitivity and accuracy.
IgA nephropathy (IgAN) is characterized by mesangial cell proliferation and extracellular matrix expansion associated with immune deposits consisting of galactose-deficient polymeric IgA1 and C3. We have previously shown that IgA-binding regions of streptococcal M proteins colocalize with IgA in mesangial immune deposits in patients with IgAN. In the present study, the IgA-binding M4 protein from
Osteoporosis is a widespread problem afflicting millions of people. Drynol Cibotinis is a newly developed proprietary botanical combination of eight botanicals including Angelica sinensis, Glycine max, Wild yam, Ligustrum lucidum, Astragalus membranaceus, Cuscuta chinensis, Psoraleae corylifoliae, and Drynaria fortune. Each of the botanicals has been used in traditional Chinese medicine to treat o
BACKGROUND: The effectiveness of mammography screening for women ages 40 to 49 years still is questioned, and few studies of the effectiveness of service screening for this age group have been conducted. METHODS: Breast cancer mortality was compared between women who were invited to service screening at ages 40 to 49 years (study group) and women in the same age group who were not invited during 1
