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Background: Delineation of organs at risk (OAR) for anal cancer radiation therapy treatment planning is a manual and time-consuming process. Deep learning-based methods can accelerate and partially automate this task. The aim of this study was to develop and evaluate a deep learning model for automated and improved segmentations of OAR in the pelvic region. Methods: A 3D, deeply supervised U-Net a
This paper examines relationship between fans and merchants in the Hogswatch celebration; a celebration of all things Discworld held in November in Wincanton, Somerset. Using socioeconomic theories on the different modes of exchange – gift economy (Gavin & Phipps) – the article explicates a relationship between fandom and dealers of intertextually linked products, resembles a gift economy syst
Climate change is rapidly altering the Arctic environment. Although long-term environmental observations have been made at a few locations in the Arctic, the incomplete coverage from ground stations is a main limitation to observations in these remote areas. Here we present a wind and sun powered multi-purpose mobile observatory (ARC-MO) that enables near real time measurements of air, ice, land,
Gruv- och ballastindustrin utgör en mycket viktig sektor i den svenska ekonomin. Där gruvindustrin operar på den globala arenan medan sten branschen operar på regional/lokal basis. Efterfrågan av metaller- och byggnadsmaterial har ökat under det senaste decenniet och mängden fasta mineraler och stenar som tas ut ur jordskorpan är nästan 80 miljarder ton per år, med ballast som den största delen.DeThe mining and quarrying industries represent a highly important sector of the Swedish economy. The mining industry operates globally, whereas the quarrying industry operates on a regional/local basis. Demands for metal and construction aggregates have increased over the last decade, and almost 80 billion tons of solid minerals and rocks are extracted from the earth’s crust each year. Construction
Background: Post-covid syndrome is an emerging condition involving a wide range of symptoms, including high rates of poor mental health. The diagnostic relevance and clinical severity of these symptoms are largely unknown, and evidence for treatment of post-covid mental health symptoms is lacking. This protocol describes a pilot randomized clinical trial, primarily aiming to assess feasibility, pa
Affibody molecules, small (7 kDa) scaffold proteins, are a promising class of probes for radionuclide molecular imaging. Radiolabeling of Affibody molecules with the positron-emitting nuclide 68Ga would permit the use of positron emission tomography (PET), providing better resolution, sensitivity, and quantification accuracy than single-photon emission computed tomography (SPECT). The synthetic an
Introduction: Understanding symptom patterns in atrial fibrillation (AF) can help in disease management. We report on the application of natural language processing (NLP) to electronic medical records (EMRs) to capture symptom reports in patients with newly diagnosed (incident) AF. Methods and Results: This observational retrospective study included adult patients with an index diagnosis of incide
Purpose: The aim of this study was to translate the health-related quality-of-life questionnaire EORTC QLQ-LMC21 into Swedish and to test its clinical and psychometric reliability and validity in patients with liver metastases from colorectal cancer (CRC) undergoing surgical treatment. Methods: The Swedish versions of the EORTC QLQ-C30 and EORTC QLQ-LMC21 were administered to 250 patients with liv
Functionalized computed tomography (CT) in combination with labelled cells is virtually non-existent due to the limited sensitivity of X-ray-absorption-based imaging, but would be highly desirable to realise cell tracking studies in entire organisms. In this study we applied in-line free propagation X-ray phase-contrast CT (XPCT) in an allergic asthma mouse model to assess structural changes as we
Purpose: Positron emission tomography (PET) is increasingly used in neuro-oncology. However, little is known about its application across European institutions and reasons for variable implementation. Methods: Between June and August 2024, members of the European Organisation for Research and Treatment of Cancer - Brain Tumour Group (EORTC-BTG) completed a cross-sectional online survey on PET use
A search is presented for direct pair production of the stop, the supersymmetric partner of the top quark, in a decay through an Formula Presented-parity violating coupling to a charged lepton and a Formula Presented-quark. The dataset corresponds to an integrated luminosity of Formula Presented of proton-proton collisions at a center-of-mass energy of Formula Presented collected between 2015 and
A general formulation for the distribution problem is presented, which is applicable to frequency distributions of subgrid-scale variables and hydrometeor size distributions, as well as to probability distributions characterizing data uncertainties. The general formulation is presented based upon two well-known basic principles: the maximum-entropy principle and the Liouville equation. The maximum
Background: Head and neck cancer patients often experience muscle wasting due to malnutrition and the hypermetabolism of cancer. For those undergoing total laryngectomy (TL), there is the potential for peri-operative complications. Sarcopenia has gained recognition as a prognostic factor in head and neck cancer. However, there is marked variability in the ways sarcopenia is defined and poor charac
Introduction Asthma may increase the risk of comorbidities and systemic inflammation, but population data are scarce. This study aimed to compare comorbidities and systemic inflammation between those with and without current asthma and to identify characteristics linked to comorbidities and biomarkers. Methods In a cross-sectional analysis of 28 828 people aged 50–64 in the Swedish CArdioPulmonary
BackgroundAdvanced Trauma Life Support® (ATLS®) is the most widely adopted form of trauma life support training worldwide, but there is no high-quality evidence that it can improve patient outcomes. The aim of this trial is to compare the effects of ATLS® training with standard care on outcomes in adult trauma patients.MethodsADVANCE TRAUMA is a batched stepped-wedge cluster randomised controlled
Technological developments now make it possible to employ many markers for many individuals in a phylogeographic setting, even for taxa with large and complex genomes such as salamanders. The banded newt (genus Ommatotriton) from the Near East has been proposed to contain three species (O. nesterovi, O. ophryticus and O. vittatus) with unclear phylogenetic relationships, apparently limited intersp
Importance: Identification and preservation of parathyroid glands (PGs) remain challenging despite advances in surgical techniques. Considerable morbidity and even mortality result from hypoparathyroidism caused by devascularization or inadvertent removal of PGs. Emerging imaging technologies hold promise to improve identification and preservation of PGs during thyroid surgery. Observation: This n
BACKGROUND: Autistic people are more likely to report problematic alcohol and other substance use when compared to the general population. Evidence suggests that up to one in three autistic adults may have an alcohol or other substance use disorder (AUD/SUD), although the evidence base for behavioural addictions is less clear. Autistic people may use substances or engage in potentially addictive b
Background: Despite being the gold standard of research to determine effectiveness, randomised controlled trials (RCTs) often struggle with participant recruitment, engagement and retention. These issues may be exacerbated when recruiting vulnerable populations, such as participants with mental health issues. We aimed to update understanding of the scope of these problems in trials of health techn
