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BACKGROUND: Early palliative care provides better quality of life, increased prognostic awareness, and even improved survival for patients with advanced cancer but how the integrated care model achieves these outcomes has not been completely explained.METHODS: To better understand the clinical approach to early outpatient care from the clinicians' perspective, we conducted focus groups with the pa

As treatment evolves and the population who survive childhood cancer ages and increases in number, researchers must use novel approaches to prevent, identify and mitigate adverse effects of treatment. Future priorities include collaborative efforts to pool large cohort data to improve detection of late effects, identify late effects of novel therapies, and determine the contribution of genetic fac

Background and Purpose-We have previously shown that delivery of brain-derived neurotrophic factor (BDNF) through direct intrahippocampal gene transduction with a viral vector suppresses the formation of new dentate granule cells triggered by global forebrain ischemia. Here, we investigated whether inhibition of endogenous BDNF alters ischemia-induced neurogenesis in the dentate gyrus. Methods-Rat

Our research group on paediatric haematology is focused on bleeding- and coagulation disorders in children, in particular on haemophilia and venous thrombosis. Haemophilia A and B are hereditary, X chromosomal recessive bleeding disorders caused by deficiency or absence of coagulation factors VIII (FVIII) or IX (FIX) in the blood. The general aim of this part of the research program is to improve

Staben samordnar och utvecklar Lunds universitetets ekonomimodell, förvaltar och utvecklar de IT-system som sektionen Ekonomi ansvarar för. Samordnar och utvecklar sektionens stöd i form av utbildning, information och support. Utvecklar och ansvarar för konsolidering av universitetets totalbudget samt ekonomiska uppföljning och analys. Ger stöd och råd i budget och uppföljningsfrågor. Leder och u

MedCUL är Medicinska fakultetens Centrum för Undervisning och Lärande. Vi erbjuder kompetensutveckling inom undervisning och lärande. Vi verkar för att utformning av, beslut om och genomförande av utbildning ska vila på aktuellt internationellt kunskapsläge inom utbildningsområdet.MedCUL coordinates the faculty's quality assurance work at undergraduate level in cooperation with educational committees and program directors. We collaborate with teachers and educational leaders in developmental projects. Our research in medical education concerns areas related to our practice such as Problem Based Learning (PBL), workplace learning and supervision, PhD student supervision and

Streptococcus bovis/Streptococcus equinus complex (SBSEC) is a common cause of infective endocarditis (IE). For IE-pathogens, the capacity to activate and aggregate platelets is believed to be an important virulence mechanism. While the interactions between bacteria and platelets have been described in detail for many Gram-positive pathogens, little research has been carried out with SBSEC in this

Forskargruppen studerar gynekologisk cancer och förebyggande av livmoderhalscancer och benskörhet. Självprovtagning från slidan för HPV-analyser och andra diagnostiska metoder såsom metyleringsanalyser visar lovande resultat för att förebygga livmoderhalscancer. Avseende äggstocks- och livmodercancer letar vi efter biomarkörspaneler och DNA-mutationer i blod för diagnostik och att prediktera prognWe study Gynecological cancer and the prevention of cervical cancer and osteoporosis. We evaluate self-sampling HPV analyses and other diagnostic methods such as methylation analyses in cervical cancer prevention. In ovarian and endometrial cancer, we search for biomarker panels and cell free DNA mutations as diagnostic and predictive markers. We study Quality of Life (QoL) and patient related exp

This review summarizes the knowledge on striated domains, which are ordered assemblies of transmembrane peptides and lipids under gel-state conditions. The structure, mechanism of function and utility of this system as a model for domain formation is described, resulting in a molecular description of the domains and a discussion on the relevance of these insights for the function/formation and str

Understanding and therapeutic targeting of lysosome-dependent cell death 1. Deciphering the molecular machinery of lysosome-dependent cell death and its interactions with other cell death and survival processes 2. Understanding the role of lysosomes in diseases with altered cell death 3. Therapeutic modulation of lysosome-dependent cell death 4. Development of novel tools and methods for study

Epilepsy is a devastating neurological disorder characterized by synchronous neuronal activity, which manifests as epileptic seizures. It usually develops after an initial insult, such as head trauma or stroke, which triggers the epileptogenic process. During epileptogenesis, the affected brain regions undergo multiple changes in connectivity and gene expression, and among the most affected genes Epilepsy is a devastating neurological disorder characterized by synchronous neuronal activity, which manifests as epileptic seizures. It usually develops after an initial insult, such as head trauma or stroke, which triggers the epileptogenic process. During epileptogenesis, the affected brain regions undergo multiple changes in connectivity and gene expression, and among the most affected genes

Paper for the Public and Social Innovation Conference (PUBSIC), Lillehammer University College, Lillehammer, Norway, 15-17 November, 2017 Theme 7B: managing and evaluating sustainable innovation In search of a model for sustainable innovation in welfare services Katja Lindqvist & Ulrika WestrupDepartment of Service Management and Service Studies, Lund University, Swedenkatja.lindqvist@ism.lu.s

BACKGROUND: Globally, 700 000 people die every year by suicide. Health care consultation patterns the period before suicide could be one potential way to identify people at risk for suicide. Therefore, this study examines health care patterns up to one year prior to the suicide by age, sex and prior diagnoses and specifically investigates if and how this differs from the general population of Skån

Konstnärliga fakulteten bedriver forskning vid Inter Arts Center samt de tre institutionerna, med inriktning konst, teater och musik. Här bedrivs forskning inom ämnet fri konst, teater, musik och musikpedagogik. Forskningen kännetecknas av olika former av kunskap och influeras av många olika områden. Fakulteten samarbetar även med andra konstnärliga lärosäten i landet kring forskarutbildning för dResearch at the Faculty of Fine and Performing Arts are carried out at the Inter Arts Center and the three academies: art, theatre, and music. The faculty conducts research in fine art, theatre, music, and music pedagogy. Research in the fine and performing arts is characterized by diverse forms of knowledge and influences from many different areas. The Faculty of Arts also collaborates with other

Handelsrätt är ett juridiskt ämne, som handlar om de regler och normer som har betydelse för ekonomisk verksamhet, nationellt såväl som internationellt. Handelsrätten reglerar företagens verksamhet och är alltså den samlande beteckningen på de olika delar av juridiken som är speciellt viktiga för företaget. Hit räknas t ex avtalsrätt, bolagsrätt, skatterätt, arbetsrätt, immaterialrätt och konkurreBusiness law is a legal discipline focused on the norms and rules that impact the business sector, both nationally in Sweden and internationally. Business law regulates companies’ operations and is an umbrella term covering the braches of law that are especially important for businesses. This covers, for example, contract law, corporate law, tax law, labour law, intellectual property law and compe

Cereal grasses of the Triticeae tribe have been the major food source in temperate regions since the dawn of agriculture. Their large genomes are characterized by a high content of repetitive elements and large pericentromeric regions that are virtually devoid of meiotic recombination. Here we present a high-quality reference genome assembly for barley (Hordeum vulgare L.). We use chromosome confo