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Hypersecretion of airway mucus is a characteristic feature of chronic airway diseases like cystic fibrosis (CF) and leads via impairment of the muco-ciliary clearance and bacterial superinfection to respiratory failure. The major components of the mucus matrix forming family of mucins in the airways are MUC5AC and MUC5B. To investigate the expression of these glycoproteins in CF, immunohistochemis

Popular Abstract in Swedish Populärvetenskaplig sammanfattning Dramatiska händelser har inträffat regelbundet under jordens historia. Primära, kortvariga katastrofer som t ex asteroidnedslag, omfattande vulkanism eller kraftiga jordskalv kan ge långvariga miljöeffekter, som t ex global uppvärmning eller nedkylning, förändringar i havsnivå och cirkulationsmönster, syrefria oceanbottnar mm. Alla deGeological and biological catastrophic events have occurred repeatedly in the Earth's history, leaving traces in the global stratigraphical record in the form of sedimentary features, geochemical anomalies and biotic turnovers. This thesis focuses on the sedimentological and geochemical signatures of several key events in the Phanerozoic stratigraphical record, and aims to interpret the different

The lengths of orthologous protein families in Eukarya are almost double the lengths found in Bacteria and Archaea. Here we examine protein structures in 745 genomes and show that protein length differences between superkingdoms arise as much shorter prokaryotic nondomain linker sequences. Eukaryotic, bacterial, and archaeal linkers are 250, 86, and 73 aa residues in length, respectively, whereas

The bifunctional taxoid-colchicinoid hybrids 6-8 were synthesized and evaluated in assays of cytotoxicity and tubulin assembly/disassembly. All compounds showed a high degree of cytotoxicity, but, while 6 and 7 behaved as bifunctional tubulin binders not unlike an equimolecular mixture of taxol and thiocolchicine, 8 was surprisingly devoid of tubulin activity, acting on a distinct and yet to ident

The system water-oil (n-decane)-nonionic surfactant (C12E5) forms bilayer phases in a large concentration region, but, for a given oil-to-surfactant ratio, only in a narrow temperature range. In addition to the anisotropic lamellar phase (L-alpha) there is also, at slightly higher temperature, a sponge or L-3-phase where the bilayers build up an isotropic structure extending macroscopically in thr

Cereal powders containing 33, 18 and 4% (w/w) (1→3,1→4)--glucan, prepared from cereal suspensions, had distinct differences in surface morphology as observed by scanning electron microscopy, depending both on the drying process (spray- or freeze-drying) and the dietary fibre level. Freeze-drying produced powders with a ‘flake-like’ matrix, without particle formation and similar matrix morphology i

The spectrum of six times ionized sulphur, S VII, has been investigated in the wavelength region 200-4000 Angstrom by means of the beam-foil and laser-produced plasma techniques. The analysis comprises 219 lines of which 105 are newly identified. The present work establishes 123 2s(2)2p(5)nl energy levels of which 66 are new. The level energies are determined with an internal consistency of better

Acoustic standing wave technology combined with microtechnology opens up new areas for the development of advanced particle and cell separating microfluidic systems. This tutorial review outlines the fundamental work performed on continuous flow acoustic standing wave separation of particles in macro scale systems. The transition to the microchip format is further surveyed, where both fabrication

When semi-natural pastures are abandoned, specialized grassland species are lost as a consequence of succession. As a counter-measure, previously abandoned grasslands may be restored by clearing shrubs and trees and re-introducing grazing livestock. In order to examine the effects of this type of habitat restoration, we compared species richness of plants and of specialized plants thought to be de

There is no generally accepted standard chemotherapy in treatment of advanced and recurrent endometrial carcinoma. Cisplatin and doxorubicin with or without cyclophosphamide are widely used. Response rates have improved with combination chemotherapy compared with single-agent therapy. A platinum analog seems to be an important part of the chemotherapy regimen. Since few patients are cured from the

Swedish biomass production potential could be increased significantly if new production methods, such as optimised fertilisation, were to be used. Optimised fertilisation on 25% of Swedish forest land and the use of stem wood could almost double the biomass potential from forestry compared with no fertilisation, as both logging residues and large quantities of excess stem wood not needed for indus

Introduction: Fibrillatory rates can reliably be obtained from surface ECGs during atrial fibrillation (AF) and correspond with right atrial (RA) and coronary sinus (CS) rates, while both the relation with pulmonary venous (PV) rates and determinants of fibrillatory waveform are unknown. Class III antiarrhythmic drugs prolong atrial refractoriness and decrease its dispersion, effects that may be r

Anesthetized, paralyzed and mechanically ventilated pigs were hypoventilated to extreme hypercapnia (PaCO2 approximately 20 kPa) at FiO2 0.5, and allotted to receive hypothermia (approximately 31.5 degrees C) and buffer infusion, (HB-group, n = 6) or to a hypothermic control group (H-group, n = 6). The HB-group had higher arterial pH (7.34 vs 7.09, P < 0.01) and plasma bicarbonate (58.8 vs 35.4 mm

Human plasma samples from 50 wives of fishermen have been analyzed with respect to PCBs. The non-ortho-substituted PCB congeners CB-126 and CB-169 were determined by mass spectrometry in negative ion chemical ionization mode, which demonstrated a limit of detection of 30 fg. The recoveries of the internal standards used for determination of ortho-substituted CBs were approximately 95%. Two methods

In the current study, we used bootstrap analyses and the common principal component (CPC) method of Flury (1988) to estimate and compare the G-matrix of Scabiosa columbaria and S. canescens populations. We found three major patterns in the G-matrices: (i) the magnitude of the (co)variances was more variable among characters than among populations, (ii) different populations showed high (co)varianc