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The SRY (sex determining region Y)-box 11 (SOX11) gene, located on chromosome 2p25, encodes for a transcription factor that is involved in tissue remodeling during embryogenesis and is crucial for neurogenesis. The role for SOX11 in hematopoiesis has not yet been defined. Two genes under direct control of SOX11 are the class- III β-tubulin gene (TUBB3) in neural cells and the transcription factor
Liquid chromatography-mass spectrometry (LC-MS) and mass spectrometry imaging (MSI) are two techniques that are routinely used to study proteins, peptides, and metabolites at a large scale. Thousands of biological compounds can be identified and quantified in a single experiment with LC-MS, but many studies fail to convert this data to a better understanding of disease biology. One of the primary
BACKGROUND: The identification of novel predictors of poor outcome may help stratify cardiovascular risk. Aim was to evaluate the individual contribution of blood cell count parameters, as well as their clustering, on the risk of death and cardiovascular events over the long term in the population-based Malmö Diet and Cancer Study cohort.METHODS: In 30,447 individuals (age 57 ± 8 years), we assess
This paper tests if a strong labor movement leads to fewer industrial conflicts. The focus is on Sweden between the first general election in 1919 and the famous Saltsjöbaden Agreement in 1938, a formative period when the country transitioned from fierce labor conflicts to a state of industrial peace. Using panel data techniques to analyze more than 2,000 strikes in 103 Swedish towns, we find that
This volume discusses the topics of sin, suffering, and evil in the Hebrew Bible. It gathers fresh and innovative perspectives provided by internationally renowned biblical scholars that not only demonstrate ways in which these topics are dealt with in the Hebrew Bible itself, but also map out their lasting impact on human experience of suffering throughout history. Put into dialogue with the thou
III-V nanowires have tunable dimensions, between 40 nm and 100 nm in diameter and between 1 and 15 μm in length. Due to their small diameter, they are ideal candidates to interact with cells without detrimental effects on the cell viability. Nanowires can be used as sensors: in our case, we have shown that arrays of vertical gallium phosphide nanowires are promising materials for biosensing in mem
Background: Kidney disease is recognised as an important worldwide health burden. Kidney failure is the result of acute and chronic kidney disease and is associated with morbidity and mortality. Chronic kidney failure is associated with high-costs for society and low quality of life. Kidney failure may progress to end-stage renal disease (ESRD) that requires dialysis or kidney transplantation with
Impaired incretin effect is a culprit in Type 2 Diabetes. Cocaine- and amphetamine-regulated transcript (CART) is a regulatory peptide controlling pancreatic islet hormone secretion and beta-cell survival. Here we studied the potential expression of CART in enteroendocrine cells and examined the role of CART as a regulator of incretin secretion and expression. CART expression was found in glucose-
The effects of five different calcium antagonists (diltiazem, felodipine, nifedipine, nimodipine, and verapamil) on cat skeletal muscle resistance and capacitance vessels were studied in a whole organ preparation. These calcium antagonists seemed to have the similar qualitative effects on these vascular functions. Calcium antagonists were found to be potent inhibitors of myogenic vascular reactivi
Although the relationship between trade and the success of international sanctions has been a topic of many debates in political economy over the past 30 years, the effect of sanctions on foreign direct investment (FDI) is still largely unexplored. Using the data for 184 countries from 1970 to 2010 and bias-corrected estimators, this study tests the effect of sanction imposition on foreign investm
Understanding and predicting dense granular flows is of importance in geology and industrial applications. Still, most theoretical work has been limited to flows and packings composed of discs or spheres, a narrow subset of all possible packings. To advance our understanding of more realistic flows we here study the granular rheology of ellipses in steady-state flow with a focus on the effects of
Paleogeographic proximity of Baltica and Laurentia in the supercontinent Rodinia has been widely accepted. However, robust paleomagnetic poles are still scarce, hampering quantitative tests of proposed relative positions of the two cratons. A recent paleomagnetic study of the early Neoproterozoic Blekinge-Dalarna dolerite (BDD) dykes in Sweden provided a 946–935 Ma key pole for Baltica, but earlie
Context: Regression testing is a well-researched area. However,the majority regression testing techniques proposed by theresearchers are not getting the attention of the practitioners. Communicationgaps between industry and academia and disparity in theregression testing goals are the main reasons. Close collaboration canhelp in bridging the communication gaps and resolving the disparities.Objecti
The association of markers of myocardial injury and dysfunction with infarct size (IS) and ejection fraction (EF) are well documented. However, limited data are available on the newer high-sensitivity troponin assays and comparison with morphologic and functional assessment with cardiac magnetic resonance imaging. We aimed to examine the associations of high-sensitivity cardiac Troponin-T (hs-cTnT
BACKGROUND: Copper and zinc are essential micronutrients and cofactors of many enzymatic reactions that may be involved in liver-cancer development. We aimed to assess pre-diagnostic circulating levels of copper, zinc and their ratio (Cu/Zn) in relation to hepatocellular carcinoma (HCC), intrahepatic bile duct (IHBD) and gall bladder and biliary tract (GBTC) cancers.METHODS: A nested case-control
