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Fear conditioning is an important survival mechanism, as is the ability to generalize learned fear responses to stimuli that are similar to the original conditioned stimulus. Overgeneralization of fear learning, prominent in many anxiety disorders, is however highly maladaptive. Because sleep is involved in the consolidation of fear learning, and in active processing of information, the present st
Mutations in seven genes are robustly associated with autosomal dominant (SNCA, LRRK2, EIF4G1, VPS35) or recessive (parkin/PARK2, PINK1, DJ1/PARK7) Parkinson's disease (PD) or parkinsonism. Changes in a long list of additional genes have been suggested as causes for parkinsonism or PD, including genes for hereditary ataxias (ATXN2, ATXN3, FMR1), frontotemporal dementia (C9ORF72, GRN, MAPT, TARDBP)
A collection of iminocoumarylmethyl glycoside derivatives have been prepared by copper-catalyzed multi-component reaction of carbohydrate propargyl derivatives, sulfonyl azides, and salicylaldehyde or o-hydroxy acetophenone. The method is simple, versatile to all three components, and exceptionally high yielding. The carbohydrate N-sulfonyl iminocoumarine hybrid molecules were evaluated for bindin
Manufacturing firms aim at improving both internal and external processes to improve the competitive advantage. Such initiatives include lean practices as well as supplier rationalization and integration. In this paper, we analyze these improvement initiatives and their impact on business performance. In particular, we explore potential differences between make-to-order (MTO) and make-to-stock (MT
Consumption of oats has long been known to lower plasma total and low-density lipoprotein (LDL) cholesterol levels, an effect usually attributed to the soluble fibers β-glucans. On the basis of this cholesterol-lowering effect, oats are ascribed cardiovascular health-promoting properties. However, besides cholesterol levels, effects of oats on parameters relating to atherosclerosis development hav
This thesis is concerned with the ways in which justice is dispensed in Swedish courts in cases concerning anti-Muslim violence. Based on material accessed through the Swedish National Board for Crime Prevention and classified as Islamophobic hate crimes, the judicial treatment of cases that may involve racism is analysed. An aim is to explore how different laws against racism in the Swedish legal
OBJECTIVE: To investigate the relationships between physical performance, quality of life (QoL), and social participation among elderly men and women with a history of osteoporosis-related fractures. METHOD: The study was a population-based cross-sectional study including 155 participants aged 60 to 93 years from the Swedish longitudinal investigation, "Good Aging in Skåne." The participants had s
Efficient bit-serial realisations for maximum and minimum filters are presented. The proposed circuits are simple and suitable for VLSI implementation. The filters not only give the maximum or minimum values, but also indicate which input is the maximum or minimum in an input vector. A true single phase clock has been used to achieve high speed
The principle of proportionality is used in many different contexts. Some of these uses and contexts are first briefly indicated. This paper focusses on the use of this principle as a moral principle. I argue that under certain conditions the principle of proportionality is helpful as a guide in decision-making. But it needs to be clarified and to be used with some flexibility as a context-depende
Thrombin generation is a key process that determines the extent of a hemostatic plug or a thrombotic process. The ensuing thrombin burst is crucial for the formation of a stable fibrin clot. During its active life, thrombin exerts a multitude of highly regulated actions on the blood and the vessel wall, including the clotting of fibrinogen. The inappropriate generation of thrombin may lead to path
Popular Abstract in Swedish Avhandlingen handlar om biosyntesen av proteoglykaner. Dessa består av en proteindel som har långa kedjor av sockermolekyler bundna till sig. Det finns huvudsakligen två typer av sockerkedjor, kondroitinsulfat och heparansulfat, som båda tillverkas på en identisk fyra molekyler lång sockerkedja. Man kan likna tillverkningen eller biosyntesen vid ett löpande band inne i Proteoglycans consist of core proteins substituted with glycosaminoglycan chains. The galactosaminoglycans (GlcUA/IdoUA-GalNAc) and the glucosaminoglycans (GlcUA/IdoUA-GlcNAc) are both initiated on the same tetrasaccharide linkage region GlcUA-Gal-Gal-Xyl-protein. The proteoglycan decorin is bound to collagen fibrils in the extracellular matrix and is substituted with a single galactosaminoglycan
In a single theoretical framework, real and virtual photon interactions are modeled for gamma-p and gamma-gamma collisions. The description covers aspects from the production of jets to total cross sections, where special emphasis is put on the range of uncertainty in the modeling of a resolved photon component. Our approach extends on a model for photoproduction, where the total cross section is
