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Mitochondrially-bound dihydroorotate dehydrogenase (EC 1.3.99.11) catalyzes the fourth sequential step in the de novo synthesis of uridine monophosphate. The enzyme has been identified as or surmised to be the pharmacological target for isoxazol, triazine, cinchoninic acid and (naphtho)quinone derivatives, which exerted antiproliferative, immunosuppressive, and antiparasitic effects. Despite this
Oscillatory neural activity in the cortico-basal ganglia-thalamocortical (CBGTC) loop is associated with the motor state of a subject, but also with the availability of modulatory neurotransmitters. For example, increased low-frequency oscillations in Parkinson’s disease (PD) are related to decreased levels of dopamine and have been proposed as biomarkers to adapt and optimize therapeutic interven
Parasitoid wasps (Hymenoptera) are a highly diverse component of terrestrial habitats, yet very little is known about how their community structure and functional diversity is influenced by habitat variables. Parasitoids were sampled using Malaise traps in early and late summer across ten forest sites in the Waitakere Ranges, New Zealand. At each trap, a range of local habitat variables were measu
Hur lurar mördarbakterier våra celler? – Vetenskap och Hälsa Hoppa till innehåll Vetenskap och hälsa Populärvetenskapligt om medicinsk forskning i Skåne Teman Podd Tidskrift Prenumerera Om webbplatsen Kontakt Sök Sök Hur lurar mördarbakterier våra celler? 2011-04-13 ⚠️ Den här artikeln är mer än 5 år gammal. Nya forskningsrön kan ha tillkommit. Två neutrofiler i färd med att fagocytera bakterier.
https://www.vetenskaphalsa.se/hur-lurar-mordarbakterier-vara-celler/ - 2026-07-07
This paper studies the Clash of Civilizations hypothesis from an economic perspective. Using data on bilateral trade and measures of culture, we evaluate how the impact of cultural differences on trade evolves over time during and after the Cold War. Evidence suggests that the negative influence of cultural differences on trade is more prominent in the post-Cold War era than during the Cold War. F
Background: High-circulating level of parathyroid hormone (PTH) is associated with elevated mortality in dialysis patients. The Japanese Society for Dialysis Therapy guideline suggests a lower PTH target than other international guidelines; thus, PTH control may differ in Japan compared with other regions, and be associated with mortality. Methods: We analyzed data from hemodialysis patients with
Tuning of protein surface charge is a fundamental mechanism in biological systems. Protein charge is regulated in a physiological context by pH and interaction with counterions. We report on charge inversion and the related reentrant condensation in solutions of globular proteins with different multivalent metal cations. In particular, we focus on the changes in phase behavior and charge regulatio
Nineteenth-century British philanthropic ideas were implemented in Sweden through the agency of translation. The present investigation of translation as a form of nineteenth-century social-reform activism takes the form of a case study of the Swedish translation of two texts by British social purity campaigner Ellice Hopkins (1836–1904). The purpose of the investigation is to explore how particulaNineteenth-century British philanthropic ideas were implemented in Sweden through the agency of translation. The present investigation of translation as a form of nineteenth-century social-reform activism takes the form of a case study of the Swedish translation of two texts by British social purity campaigner Ellice Hopkins (1836–1904). The purpose of the investigation is to explore how particula
Sensitivity tests were conducted using a state-of-the-art aerosol–cloud to investigate the key microphysical and dynamical mechanisms by which solid aerosols affect glaciated clouds. The tests involved simulations of two contrasting cases of deep convection—a tropical maritime case and a midlatitude continental case, in which solid aerosol concentrations were increased from their pre-industrial (1
After insulin administration in vivo, changes in pancreatic lipase, colipase and amylase contents and outputs were assayed and quantitatively compared. The incorporation of [35S]cysteine into individual enzymes was measured. The mRNA coding for lipase and amylase were determined by dot-blot hybridization. It was found that insulin dose-dependently decreased lipase and colipase contents, but only s
Objectives: The aim of this study was to evaluate our experience with patients affected by ovarian carcinosarcoma. Patients and Methods: During a 16-year period, data on 13 patients with ovarian carcinosarcoma were collected. They were obtained from hospital charts and follow-up visits. Survival curves were estimated by the Kaplan-Meier method and compared using the log-rank test. All tests were t
Suppression of boundary-driven Rayleigh streaming has recently been demonstrated for fluids of spatial inhomogeneity in density and compressibility owing to the competition between the boundary-layer-induced streaming stress and the inhomogeneity-induced acoustic body force. To understand the implications of this for acoustofluidic particle handling in the submicrometer regime, we here characteriz
Recent climate warming has altered plant phenology at northern European latitudes, but conclusions regarding the spatial patterns of phenological change and relationships with climate are still challenging as quantitative estimates are strongly diverging. To generate consistent estimates of broad-scale spatially continuous spring plant phen
Dynamic global vegetation models are a common tool to assess the effect of climate and land use change on vegetation. Though most applications of dynamic global vegetation models use plant functional types, some also simulate species occurrences. While the current development aims to include more processes, e.g. the nitrogen cycle, the models still typically assume an ample seed supply allowing al
The aim of the present study was to investigate psychodynamic psychotherapists’ experience of the influence of personal therapy on professional growth during training with a focus on the acquisition of knowledge and the development of psychotherapeutic skills. Thematic analysis was conducted on interviews with former students (N=10) at two training institutes for psychoanalytic psychotherapy. The
