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BACKGROUND: The long-term course of coronary atherosclerosis has not been studied in large nationwide cohorts. Understanding the natural history of coronary atherosclerosis could help identify patients at risk for future coronary events. METHODS AND RESULTS: All coronary artery segments with <50% luminal stenosis in patients with a first-time coronary angio-gram between 1989 and 2017 were identifi
The naturally occurring polyether ionophore salinomycin was previously found to display promising anti-proliferative activity against bloodstream forms of Trypanosoma brucei. Here, we report the evaluation of 20-deoxysalinomycin, a naturally occurring homolog to salinomycin, for trypanocidal and cell swelling activity. The concentration of 20-deoxysalinomycin required to reduce the growth rate of
The distinction between primary and secondary iconic signs, which I first made with regard to pictures, has been applied by other scholars to language, gesture, and music. Taking stock of this process, it has become necessary to clarify the distinction, insisting on the fact that secondary iconicity is not conventionality, but a kind of iconicity which is in itself not sufficient to define a meani
This study describes the psychological characteristics of fear of brown bear (Ursus arctos) and wolf (Canis lupus) using the Cognitive Vulnerability Model. Data were obtained from a survey of 154 stakeholders. Subjective experience of fear was primarily linked to the perceived danger or harm that the animal represents and the perceived uncontrollability of the person's own response when encounteri
Objectives: The prevalence of several autoimmune diseases, including thyroid dysfunction, has been reported to be increased in patients with endometriosis. Upregulated thyroid stimulation hormone (TSH) receptors in ectopic endometrium and elevated serum titers of TSH receptor antibodies (TRAb) IgG in endometriosis patients indicates an overlap in pathophysiology. However, cross-reactivity with oth
This study deploys a critical approach to big data analytics to gauge the tentative contours of data voids in Google searches that reflect extreme-right dynamics of exclusion in the aftermath of the 2015 humanitarian crisis in Europe. The study adds complexity to the analysis of data voids, expanding the framework of investigation outside the USA context by concentrating on Germany and Sweden. Bui
The Baltic Sea coast is a primary recreation and tourism space for both the Swedish population and incoming tourists, not least from neighbouring countries. Depending on the geographical preconditions, activities in the littoral zone comprise both typical beach activities and boating, and bohemian lifestyle. Second homes are a common form of accommodation, attracting Swedes to the shore during sum
Although the Red Army left the Danish island of Bornholm 76 years ago, the Russian invasion of Ukraine has brought the memories of those events to life again. This small island, stretched between Sweden and Poland and not so far away from Kaliningrad Oblast, is rediscovering the meaning of its recent past. Miłosz Jeromin Cordes met with Jakob Seerup, a PhD, researcher and curator at Bornholm’s Mus
Samples for isolation of dictyostelid cellular slime molds were obtained from 20 collecting sites at 18 localities in south central and southeastern Madagascar during May 2009. At least thirty species of dictyostelids representing seven genera were recovered from 52 samples of soil/humus. This total included 17 species described as new to science, 13 species already known from various localities t
Purpose of review: The study aims to provide a summary of recent developments for diagnosing and managing posterior cortical atrophy (PCA). We present current efforts to improve PCA characterisation and recommendations regarding use of clinical, neuropsychological and biomarker methods in PCA diagnosis and management and highlight current knowledge gaps. Recent findings: Recent multi-centre consen
Much has been written about the risks posed by artificial intelligence (AI). This article is interested not only in what is known about these risks, but what remains unknown and how that unknowing is and should be approached. By reviewing and expanding on the scientific literature, it explores how social knowledge contributes to the understanding of AI and its regulatory challenges. The analysis i
This article is opened by explaining a specific type of hate speech: Holocaust denial. I will establish that Holocaust denial is a form of hate speech. The article is concerned with the expression of this idea by educators. I make some constructive distinctions that will help in crystallizing our treatment of teachers who are Holocaust deniers. Should we allow Holocaust deniers to teach in schools
Metallic nano-antennas are devices used to concentrate the energy in light into regions that are much smaller than the wavelength. These structures are currently used to develop new measurement and printing techniques, such as optical microscopy with sub-wavelength resolution, and high-resolution lithography. Here, we analyze and design a nano-antenna in a two-dimensional setting with the source b
The prevalence of obesity has reached pandemic proportions, and now approximately 25% of adults in Westernized countries have obesity. Recognized as a major health concern, obesity is associated with multiple comorbidities, particularly cardiometabolic disorders. In this Review, we present obesity as an evolutionarily novel condition, summarize the epidemiological evidence on its detrimental cardi
Gradient-based optimization is a potent tool in many design processes today. It is particularly useful in industries where weight considerations are crucial, such as aerospace, but can also be exploited in for example civil engineering applications to reduce the material use and thereby the environmental impact. With the advent of advanced manufacture methods, it even possesses the potential to de
