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Popular Abstract in Swedish Denna avhandling handlar om en ärftlig hjärnsjukdom som heter Huntingtons sjukdom, eller danssjuka. Sjukdomen leder till personlighetsförändringar, ofrivilliga rörelser (som ser ut som om personen dansar) och demens. Personer som drabbas dör 15-20 år efter att symptomen har brutit ut, och en god behandling eller botemedel saknas. Sjukdomen orsakas av att HuntingtongenenHuntington's disease (HD) is a hereditary neurodegenerative disorder caused by an expansion of a CAG repeat in the HD gene, that leads to dysfunction and death of striatal neurons. The pathogenetic mechanisms underlying HD are not known, but excitotoxicity and dopamine (DA) have been suggested to play a role. In this thesis, the effects of excitotoxicity and DA have been studied in striatal in vit

Popular Abstract in Swedish Värdebaserad styrning har på senare tid tilldragit sig mycket intresse från såväl akademiker som praktiker. På basis av fallstudiemetod beskrivs, analyseras och konceptualiseras värde¬bas¬erad styrning utifrån ett ekonomistyrningsperspektiv. Medan tidigare forskning har fokuserat på de presstationsmått som lanseras i den normativa litteraturen visar denna avhandling atValue-based management has attracted considerable interest among organizations and academics in recent years. Responding to calls for case-based research, this thesis describes, analyses and conceptualizes value-based management as a management accounting construct. While previous research has focused on the measures (eg. EVA) advanced in the normative literature, this analysis demonstrates that

This thesis provides the first attempt to study the nicotinamides and benzamides from a mode of action point of veiw. Understanding the effects on DNA repair, cell cycle control (proliferation) and cell death from these agents and in combination with ionizing radiation, provides a new opportunity to logically develop better approaches to sensitize already existing therapies via for example inducti

Component C4 of human complement was purified from fresh frozen plasma with a yield of 25% using an initial batch separation with quaternary diethyl-(2-hydroxypropyl)aminoethyl--Sephadex followed by column chromatography on DEAE-cellulose and gel filtration in Sephadex G-200. The final product was homogenous according to polyacrylamide gel electrophoresis and immunochemical methods. Low-speed sedi

Objective To investigate the possible association of the BANK1 gene with genetic susceptibility to systemic sclerosis (SSc) and its subphenotypes. Methods A large multicentre case-control association study including 2380 patients with SSc and 3270 healthy controls from six independent case-control sets of Caucasian ancestry ( American, Spanish, Dutch, German, Swedish and Italian) was conducted. Th

The novel human papillomavirus type 154 (HPV154) was characterized from a wart on the crena ani of a three-year-old boy. It was previously designated as the putative HPV type FADI3 by sequencing of a subgenomic FAP amplicon. We obtained the complete genome by combined methods including rolling circle amplification (RCA), genome walking through an adapted method for detection of integrated papillom

This paper discusses importance of a strategic planning and design process when developing long-term space exploration missions both robotic and manned. The discussion begins with reviewing current and/or traditional international perspectives on space development at the American, Russian and European space agencies. Some analogies and comparisons will be drawn upon analysis of several internation

The present paper explores possible reasons why acceptance and mindfulness techniques may be beneficial in the treatment of insomnia. First, it is argued that sleep is facilitated by cognitive deactivation, with less controlled information processing as compared with daytime functioning, and correspondingly more acceptance of spontaneously occurring physiological and mental processes. Second, it i

BACKGROUND: The study is part of a collaborative project (Inuendo), aiming to assess the impact of dietary persistent organochlorine pollutants (POPs) on human fertility. The aims with the present study are to analyze inter-population variations in serum concentrations of 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE), to assess inter-popul

This study aimed to establish whether the temperature-dependent effect of acidification on maximum force observed in mammalian muscles also applies to frog muscle. Measurements of force, stiffness, and unloaded velocity of shortening in intact single muscle fibers from the anterior tibialis muscle of Rana temporaria were performed between 0 and 22degreesC during fused tetani in H2CO3CO2-buffered R

Poly(D,L-lactide-co-glycolide) (PLG) is probably the biodegradable polymer most often used for polymeric controlled-release formulations. Different salts have been shown to affect the swelling and degradation of PLG, which, in turn, affect the release of encapsulated drugs. In this investigation the effect of divalent cations was especially investigated. Films of PLG were incubated in phosphate bu

In service life modeling of concrete, the ion transport in the pore solution is crucial. The main deterioration phenomena associated with ions in the pore solution are (1) corrosion due to external chloride ions reaching the embedded reinforcement bars; (2) carbonation due to presence of dissolved carbon dioxide (which will form carbonic acid with water) supplied from the surrounding air; and (3)

Background: The postantibiotic effect (PAE) of meropenem and ciprofloxacin was studied in the presence of the antineoplastic agent 5-fluorouracil (5-FU). The purpose of the study was to investigate whether the PAEs of the combinations differed from the PAEs of the antibiotics alone. Methods: The PAEs of the combinations of 5-FU plus meropenem or ciprofloxacin were determined with viable counts aga

The need to estimate indoor temperatures, heating or cooling load and energy requirements for buildings arises in many stages of a buildings life cycle, e.g. at the early layout stage, during the design of a building and for energy retrofitting planning. Other purposes are to meat the authorities requirements given in building codes. All these situations require good calculation methods. The main