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Microorganisms can be equipped with synthetic genetic programs for the production of targeted therapeutic molecules. Cutibacterium acnes is the most abundant commensal of the human skin, making it an attractive chassis to create skin-delivered therapeutics. Here, we report the engineering of this bacterium to produce and secrete the therapeutic molecule neutrophil gelatinase-associated lipocalin,

https://biologi.blogg.lu.se/minutes-from-bdrs-meetings-24-3-and-26-4-22/ - 2026-06-28

Introduction: We assessed best available data on access and delivery of acute stroke unit (SU) care, intravenous thrombolysis (IVT) and endovascular treatment (EVT) in the European region in 2019 and 2020. Patients and methods: We compared national data per number of inhabitants and per 100 annual incident first-ever ischaemic strokes (AIIS) in 46 countries. Population estimates and ischaemic stro

User generated content (UGC) makes up a significant portion of Internet traffic. As opposed to other content, UGC has so far been left outside over-the-top providing network operators content distribution networks (telco-CDN) due to the difficulty in determining optimised placement of such content. The side effect of this is that UGC content is not placed close to end users and therefore occupy un

Lipid nanoparticles (LNPs) are clinically approved for mRNA-based vaccines and liver-targeted siRNA delivery. However, poor nucleic acid delivery efficiency limits their application in extrahepatic tissues and tumors. Here, using live-cell and super-resolution microscopy, we identify multiple distinct steps of inefficiencies in the cytosolic delivery of both siRNA and mRNA cargoes. Membrane damage

https://www.lu.se/evenemang/refashion-reflect-sustainable-fashion-x-lab - 2026-06-28

The essay examines whether or not utilization of clickwrap and point-and-click agreements can give rise to legal obligations according to Swedish law. Both methods seek to incorporate and bind users to standardized terms through a “click” without giving any opportunity to negotiate the terms. They are contracts of adhesion, unilaterally put forward and dictated by one of the parties. For a standa

https://www.medicin.lu.se/evenemang/jintian-huang-i-amnet-medicinsk-vetenskap - 2026-06-28

Vi studerar blod- och immunsystemet och dess sjukdomar. Ett särskilt fokusområde är hur medfödd genetisk variation påverkar hur blod- och immunceller, och hur sådan variation kan utnyttjas kliniskt. Vilka gener och genmutationer styr t ex risken för blodcancer? Kan vi utnyttja dem för att förebygga och behandla? Vilka styr vår blodgruppsuppsättning? Kan vi utnyttja dem för säkrare transfusion? EttWe study the blood and immune system and its diseases. A particular focus area is how congenital genetic variation affects blood and immune cells, and how such variation can be utilized clinically. Which genes and gene mutations control, for example, the risk of blood cancer? Can we use them to prevent and treat? Who controls our blood group set? Can we use them for safer transfusion? Another impo

25 april 2025 17:00 till 10 maj 2025 16:00 | Utställning Silver svärtas av ljus, görs okänsligt, förädlas i ett bad av guld (sel d’or) – delar av silvret ersätts av den renaste metallen: subjektet är odödliggjort.Essence of Desire erbjuder ett närgånget studium av en fotografisk skuggvärld. Ur glasnegativen träder en prismatisk bildsvit fram: fragment av en historia utan början och slut – om att s

https://www.lu.se/evenemang/essence-desire-hannes-ostlund - 2026-06-28

Poverty has a long history in Africa. Yet, the most conventional and influential history of African poverty is a very short one. As told by the World Bank, the history of poverty starts in the 1980s with the first Living Standard Measurement Study. This history of poverty by numbers is also a very narrow one. There is a disconnect between the theoretical and historical underpinnings of how academi

In this article we address the problem of projective reconstruction of structure and motion given only image data. In particular we investigate three novel minimal combinations of points and lines over three views, and give complete solutions and reconstruction methods for two of these cases: 'four points and three lines in three views', and 'two points and six lines in three views'. We show that

28 december 2025 12:00 till 17:00 | Barn- och ungdomsevenemang, Övrigt På Vattenhallen Science Center finns det mycket att upptäcka. Välkommen på ett jullovsbesök! DAGENS SHOWERKl 13.00: QuantumshowTa på dig gitterglasögonen och slå dig ner för en show full av spännande fakta om ljus, ljud, vågor och fysik! Kl 15.00: Luft & Vattenshow Häng med när våra studenter showar om luft och vatten! Vad händ

https://www.lu.se/evenemang/jullovsoppet-med-quantumshow - 2026-06-28

Incomplete lysosomal acidification in microglia inhibits the degradation of fibrillar forms of Alzheimer's amyloid β peptide (fAβ). Here we show that in primary microglia a chloride transporter, ClC-7, is not delivered efficiently to lysosomes, causing incomplete lysosomal acidification. ClC-7 protein is synthesized by microglia but it is mistargeted and appears to be degraded by an endoplasmic re