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Objective: To investigate how genetics influence the risk of smoking-related systemic lupus erythematosus (SLE) manifestations. Methods: Patients with SLE (ndiscovery cohort=776, nreplication cohort=836) were genotyped using the 200K Immunochip single nucleotide polymorphisms (SNP) Array (Illumina) and a custom array. Sixty SNPs with SLE association (p<5.0×10-8) were analysed. Signal transducer an
Introduction and abstract Government and Binding theory (Chomsky 1981, Sells 1985) plays a dominant role in current linguistics and is an almost compulsory part of the linguistics curriculum at universities. The advantage of GB is its rigorous theory, allowing only certain simple trees and transformations, supple-mented by certain simple principles and con
The thesis main objective is to establish the determinants for granting executive stock options and to examine their impact on performance for firms listed on OMXS30. The analysis is based on accounting data gathered from annual reports and Thomson Datastream. The empirical results display that firms grant stock options to mitigate the principal-agent problem. Furthermore, risk proves to be positi
In this study, the two peptides Aβ40 and Aβ42, which are related to Alzheimer’s disease, was studied. The aim was to study them in bulk solution, to understand if, and in that case how, the two peptides differ in structure and aggregation be- haviours. To investigate the structure, all-atom moleuclar dynamics simulations were used, whereas the aggregation was studied using coarse-grained Monte Car
Syftet är att beskriva och analysera VBM och BSC samt diskutera möjligheten att integrera dessa. Studien bygger på en kvalitativ metod där teoretiska begrepp inom Value Based Management och Balanced Scorecard analyseras och jämförs med empiriska undersökningar i form av intervjuer. Kombinationen av VBM och BSC resulterar i ett lämpligt styrverktyg för många företag. Det är ingen perfekt kombinatio
Apart from the substantive public procurement rules, harmonising national provisions for the award of public contracts, the Community also strives to ensure compliance with those rules. For that purposes the Remedies Directive 89/665/EEC has been adopted to ensure that effective and rapid remedies are available to aggrieved bidders. This directive has recently been amended by Directive 2007/66/EC
The study aims to investigate how independent management consultants experience the differences between supervision, mentoring and coaching and how they employ these approaches in their professional development. It also aims to find out how mentoring, coaching and supervision could be conceptualized in a strategy for independent management consultants’ professional development. The paper is based
Background: There is an internal belief within Axis that despite their products’ relatively high initial price, the total cost of ownership (TCO) of an Axis camera solution is lower than that of other brands. However, there is no internal research or tools to verify if it is true. Without this, Axis is unable to communicate their belief in an educated and quantifiable way, which is desired in
This thesis is a comparative legal research of the enforcement of maritime claims in two countries of the Baltic sea region - Russia and Latvia. It focuses on substantive and procedural aspects of enforcement of maritime claims. Thorough analysis of the ship arrest possibilities provided under Russian and Latvian law and of encumbrances of maritime property (maritime liens and ship mortgages) is s
Changing climatic conditions is a perpetual circumstance for mankind. In this study, we investigate local environmental and climatic changes near Kangerlussuaq, west Greenland. Our reconstruction is based on a lake sediment core and methods include chemical proxies and a palynological analysis. The investigated site is located 15 km from the Aasivissuit Inuit summer hunting ground, which has been
Purpose: The aim of this study was to examine test–retest reliability and responsiveness of the short version (6-item) Hip Return to Sport after Injury (Hip-RSI) scale in patients following hip arthroscopy. Methods: The study included 100 hip arthroscopy patients responding to a digital survey including the short version (6-item) Hip-RSI, International Hip Outcome Tool (short version) (iHOT-12) an
This chapter explores the relevance of the Christian tradition to contemporary debates on solidarity in international law and human rights. It positions the genealogy of solidarity within early Christian writings in which the western theological concepts of suffering, love, and salvation are detailed. Linking the Pauline doctrine and writings of early theologians to the processes of modernity – of
Someone who throws away their rubbish on a street-corner or in a ditch is guilty of sloth. This may appear harmless, but seen through the lens of waste management, sloth soon develops into a deadly sin that harms other people’s lives and health. Hiding and forgetting waste has always been a practice with potentially disastrous consequences; buried containers full of toxins will eventually start to
Background: The COVID-19 pandemic may worsen the mental health of people reporting subjective cognitive decline (SCD) and therefore their clinical prognosis. We aimed to investigate the association between the intensity of SCD and anxious/depressive symptoms during confinement and the underlying mechanisms. Methods: Two hundred fifty cognitively unimpaired participants completed the Hospital Anxie
Two conspicuous wet shifts in the peat stratigraphy of Store Mosse in southern Sweden, associated with bog-wide changes in vegetation and degree of peat decomposition, were analysed at high resolution. The bog-surface wetness (BSW) proxy data (organic matter bulk density, C/N ratio, plant macrofossils and testate amoebae) highlight the importance of interactions between vegetation composition, mic
