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Monoclonal antibodies are among the most promising therapeutic agents in modern medicine, yet their formulation into high-concentration solutions for subcutaneous self-administration poses a major challenge. A key obstacle is the marked increase in viscosity often observed under these conditions. To gain deeper insights into this phenomenon, coarse-grained models derived from soft matter physics h

Background: Regular, detailed reporting on population health by underlying cause of death is fundamental for public health decision making. Cause-specific estimates of mortality and the subsequent effects on life expectancy worldwide are valuable metrics to gauge progress in reducing mortality rates. These estimates are particularly important following large-scale mortality spikes, such as the COV

The effect of climate change on tree growth in boreal forests is likely mediated by local climate conditions and species-specific responses that vary according to differences in traits. Here, we assess species-specific tree growth responses to climate along gradients of mean annual temperature and soil moisture. We assessed growth-climate relationships by using tree-ring width data in Norway spruc

Based on nucleotide sequences from three chloroplast DNA regions (rps16, rpl16, trnT-trnL), we infer detailed phylogenetic relationships within the subfamily Thunbergioideae (Acanthaceae) and among major lineages of the family as a whole. Taxa were sampled to cover the geographic distribution of Thunbergioideae and to include all subgenera of the largest genus Thunbergia. All other major lineages

The accuracy of pore size distributions (PSD) obtained from gas adsorption and cryoporometry is compromised by the presence of advanced adsorption and advanced melting effects, respectively. In order to improve PSD accuracy, it is necessary to know the extent of such effects. In this work cryoporometry and adsorption have been combined to study the onset of advanced melting effects in a sample par

Although Benjamin Schnieder’s theory of the “ordinary conception” of properties successfully handles paradoxical properties—particularly, the property of non-self-instantiation—it fails to account for ordinary, non-pathological cases. The theory allows the inference of ‘a has the property of being F’ only given F(a) and the prior assertibility of ‘the property of being F can exist’. While this all

Introduction. Recently, more attention is being paid to the drug-induced liver injury (DILI) as a consequence of the tuberculos is treatment and the need for new medicine is emphasized. The use of isoniazid and rifampicin has a potentiating effect, which increases the risk of substancial liver damage. In turn, systemic accumulation of toxic metabolites leads to negative changes in various organs,

We discuss two approaches for the formulation and implementation of space-time discontinuous Galerkin spectral element methods (DG-SEM). In one, time is treated as an additional coordinate direction and a Galerkin procedure is applied to the entire problem. In the other, the method of lines is used with DG-SEM in space and the fully implicit Runge–Kutta method Lobatto IIIC in time. The two approac

The purpose of this study was to describe neuromuscular and kinematic differences during failed and successful drop-vertical jumps in a pediatric population. Healthy young athletes (n = 32) completed single-leg drop vertical jump landings where the required landing leg was unanticipated. Trials were categorized as failed if the participant shifted their base of support during the landing. Joint ki

Motivational strategies are underresearched, and studies so far conducted have been in sociolinguistic contexts where English is not extensively encountered outside the classroom. Given also that little is known about strategies relating to the design and content of classroom activities, the purpose of this study is to identify and critically evaluate strategies focusing on activity design and con

TAR DNA-binding protein-43 (TDP-43) accumulation is the primary pathology underlying several neurodegenerative diseases. Charting the progression and heterogeneity of TDP-43 accumulation is necessary to better characterize TDP-43 proteinopathies, but current TDP-43 staging systems are heuristic and assume each syndrome is homogeneous. Here, we use data-driven disease progression modelling to deriv

The semiconductor technology development con- stantly enables integrated circuits (ICs) with more, faster and smaller transistors. While there are many advantages, there are also many and new challenges, for example tighter margins, wear- outs and process variations. To address these challenges, the traditional approach with external test instruments used at man- ufacturing test must be complement

The work focuses on analysis and development of integrated low-pressure shaft generator in a geared twin-spool turbofan engine. It starts with manufacturing and evaluation of direct cooled hollow conductor coils, and has focus manufacturing, assembling and integration issues essential to machine design. The experiment-in-loop, but the model-based evaluation focuses not only on the coolant and cool

Nominal classification is a robust feature in many Amazonian languages, and aspects of these systems offer significant challenges to our broader conception of the phenomenon. Yet a clear characterization of Amazonian classification systems must be firmly grounded in detailed descriptive analysis on one hand, and in a principled definition of classification as a typological category on the other –