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Iba2 is a homolog of ionized calcium-binding adapter molecule 1 (Iba1), a 17-kDa protein that binds and cross-links filamentous actin (F-actin) and localizes to membrane ruffles and phagocytic cups. Here, we present the crystal structure of human Iba2 and its homodimerization properties, F-actin cross-linking activity, cellular localization and recruitment upon bacterial invasion in comparison wit
The issuance of building permits is a crucial process for urban development in accordance with the law and sustainability goals. Building permits in Europe involve a complex tapestry of processes, regulations, and methodologies. Despite its critical role in shaping the urban landscape, detailed investigations of building permitting process have been scarce. This gap in knowledge not only hinders t
Earth observation data provide useful information for the monitoring and management of vegetation- and land-related resources. The Framework for Operational Radiometric Correction for Environmental monitoring (FORCE) was used to download, process and composite Sentinel-2 data from 2018–2020 for Uganda. Over 16,500 Sentinel-2 data granules were downloaded and processed from top of the atmosphere re
Objective: New guidelines for the interpretation of cardiotocography (CTG) have been presented by FIGO in 2015 (FIGO-15) and by NICE in 2017 (NICE-17) and 2022 (NICE-22) In Sweden, a previous template from 2009 (SWE-09) was replaced in 2017 (SWE-17). The objective of the study was to compare these five different templates for CTG classification regarding sensitivity, specificity, positive and nega
In the early 2000s, Tawfik presented his 'New View' on enzyme evolution, highlighting the role of conformational plasticity in expanding the functional diversity of limited repertoires of sequences. This view is gaining increasing traction with increasing evidence of the importance of conformational dynamics in both natural and laboratory evolution of enzymes. The past years have seen several eleg
The discussion about science's purported loss of disruptive innovation must not distract from the underlying problems that prevent science from deploying its full potential.
In recent years, remote sensing data have revealed considerable potential in unraveling crucial information regarding water balance dynamics due to their unique spatiotemporal distribution characteristics, thereby advancing multi-objective optimization algorithms in hydrological model parameter calibration. However, existing optimization frameworks based on the Soil and Water Assessment Tool (SWAT
Dams are vital for irrigation, power generation, and domestic water needs, but siltation poses a significant challenge, especially in areas prone to water erosion, potentially shortening a dam’s lifespan. The Ahmed El Hansali Dam in Morocco faces heightened siltation due to its upstream region being susceptible to erosion-prone rocks and high runoff. This study estimates the siltation at the dam f
Nanoscale detection and control of the magnetic order underpins a spectrum of condensed-matter research and device functionalities involving magnetism. The key principle involved is the breaking of time-reversal symmetry, which in ferromagnets is generated by an internal magnetization. However, the presence of a net magnetization limits device scalability and compatibility with phases, such as sup
The IFMIF-DONES Facility is a unique first-class scientific infrastructure whose construction is foreseen in Granada, Spain, in the coming years. Strong integration efforts are being made at the current project phase aiming at harmonizing the ongoing design of the different and complex Systems of the facility. The consolidation of the Diagnostics and Instrumentation, transversal across many of the
The complex orography of the Tibetan plateau (TP) and the scarcity and uneven spatial distribution of meteorological stations present significant challenges in accurately estimating meteorological variables for hydrological simulations. This study aims to enhance the accuracy of daily precipitation and temperature interpolation for hydrological simulations in the Lhasa River Basin (LRB), particula
The vast potential of using sediment adsorbed DNA as a window to past and present biodiversity rely on the ability of solid surfaces to adsorb environmental DNA. However, a comprehensive insight into DNA adsorption at surfaces in general is lacking. Soot and charcoal are carbonaceous materials widespread in the environment where they read-ily can come in contact with extracellular DNA shed from or
Trafficking in human organs, cells, and tissues has long been a source of concern for health authorities and professionals, and several international ethical guidance documents and national laws have affirmed the prohibition of trade in these substances of human origin (SoHOs). However, despite considerable attention to the issue of organ trafficking, this remains a substantial and widespread prob
This chapter looks at the DMA through the prism of pre-emption and the relationship between EU and national law. It explains the fundamentals of pre-emption in EU law and shows the consequences for the DMA and national rules that are to ensure fairness in the digital market space. It argues that fairness in the digital market with regard to business users and consumers has been exhaustively regula
Recognising the increasing complexities posed by climate challenges to urban environments, it is crucial to develop holistic capabilities for urban areas to effectively respond to climate-related risks, forming the backbone of sustainable urban planning strategies and demanding a comprehensive understanding of urban climate justice. It requires a thorough examination of how climate change exacerba
BACKGROUND: Although death in old age is unavoidable, premature death-defined here as death before age 70 years-is not. To assess whether halving premature mortality by 2050 is feasible, we examined the large variation in premature death rates before age 70 years and trends over the past 50 years (1970-2019), covering ten world regions and the 30 most-populous nations. This analysis was undertaken
This report, part of the CULTIVATE project, investigates the costs and benefits of food sharing initiatives (FSIs) in Barcelona, Spain. The study aims to understand the economic, social, and environmental impacts of FSIs, which include growing and composting together, cooking and eating together, and redistributing surplus food. The research employs a Mobile Research Lab (MRL) approach, combining
Increasing concentrations of toxic pollutants and particulate matter are a major concern related to human health. The present work is structured into two phases; the first is aimed at understanding the O3–NOX–VOC sensitivity over Delhi during the lockdown period; the second phase examines the influence of dust-induced aerosol particles on air pollution during the lockdown period using satellite-de
