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Introduction. Recently, more attention is being paid to the drug-induced liver injury (DILI) as a consequence of the tuberculos is treatment and the need for new medicine is emphasized. The use of isoniazid and rifampicin has a potentiating effect, which increases the risk of substancial liver damage. In turn, systemic accumulation of toxic metabolites leads to negative changes in various organs,
We discuss two approaches for the formulation and implementation of space-time discontinuous Galerkin spectral element methods (DG-SEM). In one, time is treated as an additional coordinate direction and a Galerkin procedure is applied to the entire problem. In the other, the method of lines is used with DG-SEM in space and the fully implicit Runge–Kutta method Lobatto IIIC in time. The two approac
The purpose of this study was to describe neuromuscular and kinematic differences during failed and successful drop-vertical jumps in a pediatric population. Healthy young athletes (n = 32) completed single-leg drop vertical jump landings where the required landing leg was unanticipated. Trials were categorized as failed if the participant shifted their base of support during the landing. Joint ki
Motivational strategies are underresearched, and studies so far conducted have been in sociolinguistic contexts where English is not extensively encountered outside the classroom. Given also that little is known about strategies relating to the design and content of classroom activities, the purpose of this study is to identify and critically evaluate strategies focusing on activity design and con
TAR DNA-binding protein-43 (TDP-43) accumulation is the primary pathology underlying several neurodegenerative diseases. Charting the progression and heterogeneity of TDP-43 accumulation is necessary to better characterize TDP-43 proteinopathies, but current TDP-43 staging systems are heuristic and assume each syndrome is homogeneous. Here, we use data-driven disease progression modelling to deriv
The semiconductor technology development con- stantly enables integrated circuits (ICs) with more, faster and smaller transistors. While there are many advantages, there are also many and new challenges, for example tighter margins, wear- outs and process variations. To address these challenges, the traditional approach with external test instruments used at man- ufacturing test must be complement
The work focuses on analysis and development of integrated low-pressure shaft generator in a geared twin-spool turbofan engine. It starts with manufacturing and evaluation of direct cooled hollow conductor coils, and has focus manufacturing, assembling and integration issues essential to machine design. The experiment-in-loop, but the model-based evaluation focuses not only on the coolant and cool
In the ENVRI-FAIR project brief on implementation of Open Science and EOSC targets the current achievements and planned activities in ENVRI-FAIR are summarised with regard to a) Integration with the EOSC infrastructure b) FAIR principles implementation and repositories c) Technical, semantic, legal and organisational interoperability d) Stewardship of data and e) Cross-cluster collaboration activi
Focused environmental research projects and continuously operating research infrastructures (RIs) designed for monitoring all subdomains of the Earth system contribute to global observing systems and serve as crucial information sources for environmental scientists in their quest for understanding and interpreting the complex Earth System and contribute to global observing systems. The EU funded E
Background: Epidemiological studies have documented an inverse relationship between testosterone levels and risk of cardiovascular disease. The present study aimed to explore the association between testosterone levels and risk of developing diabetes mellitus from 108 middle-aged men with no history of medical diseases.Methods: Data regarding the age of subjects, smoking, alcohol consumption, wais
Understanding the public's views and acceptability of shared micromobility (SMM) is crucial for uncovering barriers to incorporating SMM into sustainable urban mobility. This research studies stereotypes of SMM and their impacts on SMM's public acceptability. We focus on shared e-scooters and shared bikes/e-bikes in England, the Netherlands, and Sweden. We conceptualise stereotypes of SMM, develop
We have found the deposition technology at which the interface roughness of Nb/Si multilayer is strongly correlated and decreases with deposited layer number. On the basis of our Nb/Si multilayer we succeeded to prepare ten-fold stacked Josephson junction (JJ). Basic electric properties of stacked JJ are presented.
As the proverbial noose tightens around humanity’s resource spending, research is focused on utilizing materials to their fullest potential. Nanotechnology is the ultimate way to economize by splitting objects into smaller parts and dispersing the material properties over greater surface to volume ratios. Emerging quantum effects at the nanoscale present unique tweaking opportunities in applicatio
Chronic liver disease is a major public health burden worldwide1. Although different aetiologies and mechanisms of liver injury exist, progression of chronic liver disease follows a common pathway of liver inflammation, injury and fibrosis2. Here we examined the association between clonal haematopoiesis of indeterminate potential (CHIP) and chronic liver disease in 214,563 individuals from 4 indep
