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Thylakoid membranes derived from green leaf chloroplasts affect appetite-regulating hormones, suppress food intake, reduce blood lipids and lead to a decreased body weight in animals and human subjects. Thylakoids also decrease the intestinal in vitro uptake of methyl-glucose in the rat. The aim of this study was to investigate the effect of dietary thylakoids on the gut microbiota composition, ma
Studiens syfte är att utvidga kunskapen om berggrunden på södra Gotlands och koppla det till den ansträngda grundvattensituation i området. Materialet till studien kommer från Sveriges geologiska undersök-ning (SGU) som utfört geofysiska borrhålsmätningar och flygburna resistivitetsmätningar (SkyTEM) och från Olje-prospekterings AB (OPAB) som på 70- och 80-talet gjorde borrningar på Gotland i syftThis study aims to expand the knowledge about the bedrock in southern Gotland and link it to the strained groundwater situation that is there. The material for the study comes from the Swedish Geological Survey (SGU) which conducted geophysical borehole measurements and airborne resistivity measurements (SkyTEM) and from OPAB, which in the 70’s and 80’s drilled several wells on Gotland for the pur
Studying gene-lifestyle interaction may help to identify lifestyle factors that modify genetic susceptibility and uncover genetic loci exerting important subgroup effects. Adequately powered studies with prospective, unbiased, standardised assessment of key behavioural factors for gene-lifestyle studies are lacking. This case-cohort study aims to investigate how genetic and potentially modifiable
In cystic fibrosis (CF), colonization of the airways with Pseudomonas aeruginosa is associated with disease deterioration. The mechanism behind the disease progression is not fully understood. The present work shows that the antibacterial chemokine MIG/CXCL9 is present in the airways and in sputum of CF patients. MIG/CXCL9 showed high bactericidal activity against. P. aeruginosa, including some st
2-Oxoglutaric acid (2-Ox), a precursor to hydroxyproline - the most abundant amino acid in bone collagen, exerts protective effects on bone development during different stages of organism development; however, little is known about the action of 2-Ox on cartilage. The aim of the present study was to elucidate the influence of dietary 2-Ox supplementation on the growth plate, articular cartilage an
In this paper, a novel multiple representation data structure for dynamic visualisation of 3D city models, called CityTree, is proposed. To create a CityTree, the ground plans of the buildings are generated and simplified. Then, the buildings are divided into clusters by the road network and one CityTree is created for each cluster. The leaf nodes of the CityTree represent the original 3D objects
To manage increasingly complicated 3D city models, a framework based on NoSQL database is proposed in this paper. The framework supports import and export of 3D city model according to international standards such as CityGML, KML/COLLADA and X3D. We also suggest and implement 3D model analysis and visualization in the framework. For city model analysis, 3D geometry data and semantic information (s
Purpose: This thesis aims to develop conceptual implications from interpretation of theories and case study on cross border M&As conducted by firms from emerging market with focus on the perspectives of motivation, integration and performance. Methodology: This thesis is developed through a descriptive case study on two related cases from emerging markets. Detailed implications are derived fro
Reproducible climate reconstructions of the Common Era (1 CE to present) are key to placing industrial-era warming into the context of natural climatic variability. Here we present a community-sourced database of temperature-sensitive proxy records from the PAGES2k initiative. The database gathers 692 records from 648 locations, including all continental regions and major ocean basins. The records
Looking at globular proteins with the eyes of a colloid scientist has a long tradition, in fact a significant part of the early colloid literature was focused on protein solutions. However, it has also been recognized that proteins are much more complex than the typical hard sphere-like synthetic model colloids. Proteins are not perfect spheres, their interaction potentials are in general not isot
A sediment sequence from a small forest lake in southwestern Sweden was investigated to explore the effects of forestry and land-use on catchment erosion and delivery of organic and minerogenic matter to the lake. Catchment-scale vegetation changes during the last 1,100 years were reconstructed quantitatively at 50-year resolution using pollen analysis and the Landscape reconstruction algorithm (L
We reconstructed the past coastal environment of the Baltic Sea from c. 7300 to 3500 cal. a BP, with a focus on sea surface salinity (SSS). To quantitatively determine the SSS, two methods were employed: measurements of 87Sr/86Sr ratios in mollusc shells (SSSS r) and process length variations of dinoflagellate cysts Operculodinium centrocarpum (SSSpl). The SSSS r was ~6–7 between 6
INTRODUCTION: Primary graft dysfunction (PGD) is a leading cause of 30-day mortality following heart transplantation, and early intervention in PGD may correlate to improved survival. Our analysis aimed to determine the feasibility of measuring cardiac biomarkers from the donor heart in the early phase for use as a predictor of PGD.METHODS: Blood samples from the coronary sinus were obtained at th
Using light scattering (LS), small-angle X-ray scattering (SAXS), and coarse-grained Monte Carlo (MC) simulations, we studied the self-interactions of two monoclonal antibodies (mAbs), PPI03 and PPI13. With LS measurements, we obtained the osmotic second virial coefficient, B22, and the molecular weight, Mw, of the two mAbs, while with SAXS measurements, we studied the mAbs' self-interaction behav
The mechanical response of lipid membranes to nanoscale deformations is of fundamental importance for understanding how these interfaces behave in multiple biological processes; in particular, the nanoscale mechanics of non-lamellar membranes represents a largely unexplored research field. Among these mesophases, inverse bicontinuous cubic phase QII membranes have been found to spontaneously occur
Intrinsically disordered proteins (IDPs) are proteins that, in comparison with globular/structured proteins, lack a distinct tertiary structure. Here, we use the model IDP, Histatin 5, for studying its dynamical properties under self-crowding conditions with quasi-elastic neutron scattering in combination with full atomistic molecular dynamics (MD) simulations. The aim is to determine the effects
Background: Oral administration of health-promoting bacteria is increasingly used in clinical practise. These bacteria have anti-inflammatory characteristics and modulate the immune system without major reported side effects. The mechanisms of action are not yet fully defined. Our aim was to study systemic effects of probiotics by measurements of leukocytes as well as local effects on rectal mucos
The bioactivity, biological fate and cytotoxicity of nanomaterials when they come into contact with living organisms are determined by their interaction with biomacromolecules and biological barriers. In this context, the role of symmetry/shape anisotropy of both the nanomaterials and biological interfaces in their mutual interaction, is a relatively unaddressed issue. Here, we study the interacti
