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Coherent extreme ultraviolet (XUV) light sources are necessary for the investigation of physical processes in the natural length and time scales of atoms. These experiments require a high degree of control of the coherent XUV light. The optical components and techniques, which are available for visible and infrared light, unfortunately cannot be used for controlling XUV light. In this thesis, nove
Therapeutic antibodies are the fastest growing class of drugs but suffer from a crowded target-space where many antibodies, against a few targets, are developed in parallel. The aim of this thesis is to find methods to enable discovery of novel antibody-target combinations and thereby increase the target-space. A strategy to achieve this is to use phage display antibody libraries and selection on
Cerebral autoregulation is crucial for maintaining cerebral blood flow and perfusion. In recent years, the importance of cerebral oxygenation in syncope and orthostatic intolerance (OI) has received increased attention. Cerebral tissue oxygenation can be measured by using near-infrared spectroscopy (NIRS), which determines the ratio of oxygenated hemoglobin to total hemoglobin in cerebral tissue.
Peptide self-assembly is a spontaneous process, ubiquitous in nature for the creation of highly ordered and complex biological structures, making it a sought after technique in the development of novel biocompatible materials. The process is also strongly associated with various neurodegenerative diseases in the formation of amyloid plaques in diseases such as Alzheimer’s and Parkinson’s, where f
In the last decade the Internet as we know it has developed rapidly. With it music has been spread, consumed and absorbed in manners that ultimately questions both its status as well as its possibilities. In a digital age, does it make sense to think of music as progressing after certain inherent logics? Is music not enmeshed in our digital doings to such a degree that the entire foundation for ho
The evaluation of satellite precipitation products (SPPs) at regional and local scales is essential in improving satellite-based algorithms and sensors, as well as in providing valuable guidance when choosing alternative precipitation data for the local community. The Tropical Rainfall Measuring Mission (TRMM) has made significant contributions to the development of various SPPs since its launch i
Embryonal tumours with multilayered rosettes (ETMRs) are aggressive paediatric embryonal brain tumours with a universally poor prognosis1. Here we collected 193 primary ETMRs and 23 matched relapse samples to investigate the genomic landscape of this distinct tumour type. We found that patients with tumours in which the proposed driver C19MC2–4 was not amplified frequently had germline mutations i
What determines inequality and mobility of wealth? This paper quantifies in closed form both the bottom and the top (Pareto) tail of the distribution for a rich continuous-time model. The distribution is especially shaped by bequest motives, demographics, and the asset portfolio composition under idiosyncratic wealth risk. Factors that increase inequality also reduce mobility. The model - enriched
A plant bioassay was used to enumerate infectious Frankia in soil and micro- and molecular techniques were used to identify possible mechanisms by which Frankia survive drying.Myrica-nodulating Frankia occurred in five Hawaiian volcanic deposits with depositional ages ranging from 20 to 162 years before present. The oldest deposit had a mean estimated nodulation capacity from 450 to 1200 times gre
Experimental studies have suggested an atheroprotective role of interleukin (IL)-5 through the stimulation of natural immunoglobulin M antibody expression. In the present study we show that there are no associations between baseline levels of IL-5 and risk for development of coronary events or stroke during a 15.7 ± 6.3 years follow-up of 696 subjects randomly sampled from the Malmö Diet and Cance
BACKGROUND: Obesity is an established risk factor for several cancers. Adult weight gain has been associated with increased cancer risk, but studies on timing and duration of adult weight gain are relatively scarce. We examined the impact of BMI (body mass index) and weight changes over time, as well as the timing and duration of excess weight, on obesity- and non-obesity-related cancers. METHODS:
The year 1937 saw the establishment of Congress Ministries in eight of the eleven provinces in which the provincial elections had been held, Bihar being one of them. The resounding victory of the Congress which secured a clear majority in the province of Bihar and the dismal performance of the Muslim League seemed at the time to depict the mood of the people in general. It was taken as a clear rej
Economic historians tend to explain US geographical development gaps in terms of industrialisation. But by the end of the 20th century, the richest counties had become specialised in services, rather than in manufacturing. This column evaluates how the service economy triggered this evident contrast between the urban and rural US. Market size causes localisation of non-agricultural activity, with
Glycerophospholipids and sphingolipids participate in a variety of indispensable metabolic, neurological, and intracellular signaling processes. In this didactic paper we review the biological roles of phospholipids and try to unravel the precise nature of their putative healthful activities. We conclude that the biological actions of phospholipids activities potentially be nutraceutically exploit
BACKGROUND: Selenium is an essential element with a rich and varied chemistry in living organisms. It plays a variety of important roles ranging from being essential in enzymes that are critical for redox homeostasis to acting as a deterrent for herbivory in hyperaccumulating plants. Despite its importance there are many open questions, especially related to its chemistry in situ within living org
Fifth-generation (5G) new radio (NR) deployments are being rolled out in both the C–band (3.3 - 5.0 GHz) and millimeter-wave (mmWave) band (24.5 - 29.5 GHz). For outdoor scenarios, the C–band is expected to provide wide area coverage and throughput uniformity, whereas the mmWave band is expected to provide ultra-high throughput to dedicated areas within the C-band coverage. Due to the differences
