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How neurons can maintain cellular identity over an entire life span remains largely unknown. Here, we show that maintenance of identity in differentiated dopaminergic and serotonergic neurons is critically reliant on the Polycomb repressive complex 2 (PRC2). Deletion of the obligate PRC2 component, Eed, in these neurons resulted in global loss of H3K27me3, followed by a gradual activation of genes
The article argues that in Denmark during the past 150 years, moral elites have been central in settling paradoxes within social policy by developing ‘classifications’ of citizens and sectors: who are deserving of help and what sector (public or third) should provide care. Contrary to widely held beliefs, historically, there is no logical or practical connection between ‘more deserving’ and ‘state
Monitoring time-dependence with diffusion MRI yields observables sensitive to compartment sizes (restricted diffusion) and membrane permeability (water exchange). However, restricted diffusion and exchange have opposite effects on the diffusion-weighted signal, which can lead to errors in parameter estimates. In this work, we propose a signal representation that incorporates the effects of both re
A radioactive fallout following a nuclear accident can result in contamination of large areas of land. In order to protect human health against ionizing radiation, large-scale decontamination that includes multiple sets of clean-up measures may be necessary. Sweden lacks national experience of this type of large-scale decontamination. There are thus great uncertainties in the effect of such a deco
This article approaches listening practices and the role of technological mediation within ecological sound art, building on findings through the artistic research practices of the two authors. Through documentation of the authors’ ecological sound art practices of aeolian guitar performance, curation, composition, performance on found objects and field recording, we argue that phenomenological va
Animals vary widely in body size within and across species. This has consequences for the function of organs and body parts in both large and small individuals. How these scale, in relation to body size, reveals evolutionary investment strategies, often resulting in trade-offs between functions. Eyes exemplify these trade-offs, as they are limited by their absolute size in two key performance feat
In their recent commentary in Protein Science, Jaskolski et al. analyzed three randomly picked diffraction data sets from fragment-screening group depositions from the PDB and, based on that, they claimed that such data are principally problematic. We demonstrate here that if such data are treated properly, none of the proclaimed criticisms persist.
Introduction and Aims: Up to 80% of adolescents have experienced trauma and one-in-seven suffer from post traumatic stress disorder (PTSD). For 50% of these adolescents, the course of their illness is further complicated by a co-occurring substance use disorder (SUD). Despite high rates of comorbidity, treatment options remain sparse and there is limited understanding of the clinical profile ass
Rainfall interception and other hydrologic processes affected by the forest litter layer are usually related to litter characteristics and rainfall conditions, with limited studies that consider the influence of slope. To simulate the hydrological functions of the litter layer at different slope gradients, artificial rainfall experiments were conducted at four rainfall intensities (from 30 to 120
Behavioral variant frontotemporal dementia (bvFTD) has been predominantly considered as a frontotemporal cortical disease, with limited direct investigation of frontal–subcortical connections. We aim to characterize the grey and white matter components of frontal–thalamic and frontal–striatal circuits in bvFTD. Twenty-four patients with bvFTD and 24 healthy controls underwent morphological and dif
Anaerobic co-digestion allows for under-utilised digesters to increase biomethane production. The organic fraction of municipal solid waste (OFMSW), i.e., food waste, is an abundant substrate with high degradability and gas potential. This paper investigates the co-digestion of mixed sludge from wastewater treatment plants and OFMSW, through batch and continuous lab-scale experiments, modelling, a
Introduction: The complement system is essential for an adequate immune response. Much attention has been given to the role of complement in disease. However, to better understand complement in pathology, it is crucial to first analyze this system under different physiological conditions. The aim of the present study was therefore to investigate the inter-individual variation in complement activit
I denna rapport redovisas populationstrender för 208 svenska fågelarter för olika långa tidsperioder. Fåglarna har räknats vinter, vår och sommar enligt strikt standardiserade metoder. Sommarrespektive vinterpunktrutter har räknats sedan 1975, i huvudsak i södra Sverige. Standardrutterna räknas också på sommaren (sedan 1996) men täcker hela Sverige på ett representativt sätt. Nattaktiva fåglar harWe present the results of the Swedish Bird Survey, run by the Department of Biology, Lund University, as a part of the National Monitoring Programme of the Swedish Environmental Protection Agency. The results for 2017 include data from: 575 winter point counts in 2016/2017 (42nd winter), of which 284 were carried out during the Christmas/New Year count, 223 summer point count routes (43rd year) an
BACKGROUND: Proteomic approaches allow measurement of thousands of proteins in a single specimen, which can accelerate biomarker discovery. However, applying these technologies to massive biobanks is not currently feasible because of the practical barriers and costs of implementing such assays at scale. To overcome these challenges, we used a "virtual proteomic" approach, linking genetically predi
The enzyme nitrogenase contains a complicated MoFe7CS9 cofactor with 35 possible broken- symmetry (BS) states. We have studied how the energies of these states depend on the geometry, the surrounding protein, the DFT functional and the basis set, studying the resting state, a one- electron reduced state and a protonated state. We find that the effect of the basis set is small, up to 11 kJ/mol. Lik
