Filtyp
This thesis is based on work done by the author on the development of plasma-based electron accelerators driven by ultra-intense laser pulses and dense electron bunches. Plasma based accelerators have several benefits, such as accelerating fields around 1000 times stronger than in “conventional” radio-frequency accelerators, which can allow for shrinking the overall footprint of the accelerator. T
A method to determine the influencing parameters of a structural and damage detection system is proposed based on the value of information analysis. The value of information analysis utilizes the Bayesian pre-posterior decision theory to quantify the value of damage detection system for the structural integrity management during service life. First, the influencing parameters of the structural sys
Soil contamination is a widespread problem and actions need to be taken in order toprevent damage to the groundwater and the life around the contaminated sites. InSweden more than 80.000 sites are potentially contaminated, therefore there is ademand for accurate and efficient methods for site characterization and soilremediation. In the past, the preferred methodology for soil remediation involved
Protein denaturation in concentrated solutions consists of the unfolding of the native protein structure, and subsequent cross-linking into clusters or gel networks. While the kinetic evolution of structure has been studied for some cases, the underlying microscopic dynamics of proteins has so far been neglected. However, protein dynamics is essential to understand the specific nature of assembly
Giant Cell Tumour of Bone (GCTB) is a rare bone tumour. Locally aggressive and recurrent, it might evolve into pulmonary metastases. Our present work is aimed at investigating the involvement of the epidermal growth factor receptor (ErbB) family and its downstream effectors in the development and recurrence of GCTB. For this purpose, we used a cohort of 32 GCTB patients and we evaluated the clinic
Modes of climate variability affect global and regional climates on different spatio-temporal scales, and they have important impacts on human activities and ecosystems. As these modes are a useful tool for simplifying the understanding of the climate system, it is crucial that we gain improved knowledge of their long-term past evolution and interactions over time to contextualise their present an
“Garden phlox ‘Alma Jansson’ comes from a smallholding in Roslagen. It has been on the farm at least since 1939 when Stina Jansson moved in. It was her mother-in-law, Alma Jansson, who took care of the plants in the garden. ‘Everything comes from Grandma. She had such beautiful flowers’, said Stina. We do not know where she received or bought this variety, but it was not newly planted in 1939.” Th
Plasma concentrations of many cardiovascular and inflammatory proteins are altered after ST-elevation myocardial infarction (STEMI) and may provide prognostic information. We conducted a large-scale proteomic analysis in patients with STEMI, correlating protein levels to infarct size and left ventricular ejection fraction (LVEF) determined with cardiac magnetic resonance imaging. We analysed 131 c
Core-shell nanowires (NWs) with asymmetric shells allow for strain engineering of NW properties because of the bending resulting from the lattice mismatch between core and shell material. The bending of NWs can be readily observed by electron microscopy. Using X-ray diffraction analysis with a micro- and nano-focused beam, the bending radii found by the microscopic investigations are confirmed and
Droughts are often suspected to increase the risk of violent conflict through agricultural production shocks, and existing studies often explore these links through meteorological proxies. In Syria, an alleged agricultural collapse caused by drought is assumed to have contributed to increased migration and the conflict outbreak in 2011. Here we use satellite derived cropland and climate data to st
The promotion of locally produced food has been a growing marketing trend in recent years. Locally produced food is associated with positive values such as environmental benefits, fresher and safer products as well as contributing to building closer ties between people in local communities. We use a case study were a local fish auction was established in the Stockholm area in Sweden with the aim t
Background: Since its discovery in 2007, the importance of the human gut bacterium Prevotella copri (P. copri) has been widely recognized with its links to diet and health status and potential as next generation probiotic. Therefore, precise, convenient and cost-effective diagnostic tools for the detection and quantification of P. copri from clinical and environmental samples are needed. Results:
Malfunction and amyloid formation of the Islet Amyloid Polypeptide (IAPP) are factors contributing to Type 2 diabetes. Unravelling the mechanism of IAPP aggregate formation may forward our understanding of this process and its effect on pancreatic β-islet cell. Such mechanistic studies require access to sequence homogeneous and highly pure IAPP. Here we present a new facile protocol for the produc
Over the past years, interest in classifying drivers' behavior from data has surged. Such interest is particularly relevant for car insurance companies who, due to privacy constraints, often only have access to data from Inertial Measurement Units (IMU) or similar. In this paper, we present a semi-supervised learning solution to classify portions of trips according to whether drivers are driving a
The article focuses on the entanglement between the EU’s attempts to construct its external actions in global politics and research on the EU as a global actor. The article argues that both the development of EU external actions and the sociology of knowledge production surrounding the analysis of these actions suffer from unnecessary dichotomisation. Advocates and analysts of the EU’s normative p
Applying pre-processing and geometric transformation, for the generalization of building blocks, can lead to spatial conflicts which are mainly resolved by displacement. However, the conflicts may not be resolved, due to the insufficient space for displacement or the existence of other objects that prevent displacement. This article proposes a novel model combining building block displacement and
