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While the 8.2 ka abrupt cooling event is increasingly recognised as a major Holocene climatic anomaly, archaeological discussions of its cultural consequences have often been framed in terms of societal distress, including the collapse and abandonment of settlements. However, prehistoric communities must have responded in more diverse ways. This paper investigates the site-based socio-ecological a
Since life emerged on Earth, organisms have had to handle threats and stressors of different kinds. In freshwater ecosystems, one of these ancient stressors is the solar ultraviolet (UV) radiation. Life has been continuously exposed to it, and various behavioural and morphological adaptations have evolved to cope with the stressor. On the other hand, human activities have introduced novel stressor
This chapter explores the ways and channels through which Turkey-based political parties respond to non-resident citizens through external voting. It firstly provides a brief history of the legislation regulating external voting rights in Turkey. It then examines the representation of non-resident votes in the Turkish electoral system and in the Turkish Parliament. The chapter discusses Turkey-bas
This study applies a spatial multi-criteria analysis to assess ground suitability for pier-supported viaduct railways using the Analytical Hierarchy Process (AHP). By integrating expert judgments, the analysis evaluates six key geotechnical categories—soil type, soil depth, rock type, slope, wetness index, and groundwater occurrence—to map ground suitability. Three weight normalisation methods wer
The efficient conversion of xylose is a short board of cask effect to lignocellulosic biorefining, by markedly affecting the total economic and environmental benefits. Based on a comprehensive analysis of the current commercial status of traditional xylose utilization and industrial technology development, this review outlines new technological avenues for the efficient utilization of xylose from
The alighting and boarding times of commuter trains play a major role for the length of dwell times and are directly influenced by the flow rate of both alighting and boarding passengers, measured as the number of passengers passing through a door per second. It is, therefore, important to have a good understanding of passenger flow rates to better understand and schedule dwell times. Where previo
The Internet of Things (IoT) can be defined as the network of physical objects, or "things,"embedded with sensors and software for processing and exchanging data with other devices and ecosystems using the Internet as a medium. With its rapid growth over the past decade, it has permeated several application domains, including intelligent vehicular systems. The Internet of Autonomous Vehicles (IoAV
Democracy festivals are events that aim to strengthen democracy by engaging citizens, politicians and organisations in dialogue and provide a more equal access to the agenda. In recent years, social media have become important arenas for agenda building, supposedly equalising the access to such processes. This article uncovers patterns of activity and visibility in agenda building through an actor
In recent years, the study of body image shifted from focusing on the negative aspects to a more extensive view of body image. The present study seeks to validate a measure of positive body image, the Body Appreciation Scale-2 (BAS-2; Tylka & Wood-Barcalow, 2015a) in Denmark, Portugal, and Sweden. Participants (N = 1012) were adolescents and young adults aged from 12 to 19. Confirmatory factor
Introduction The WHO has declared climate change the defining public health challenge of the 21st century. Incorporating climate and environmental outcomes in randomised trials is essential for enhancing healthcare treatments’ sustainability and safeguarding global health. To implement such outcomes, it is necessary to establish a framework for unbiased and transparent planning and reporting. We a
Proteins and peptides are vital biomolecules, and deuterated amino acids are increasingly applied in areas such as drug discovery, metabolic tracing, and neutron scattering studies. In this study, we performed deuteration on all 20 proteinogenic amino acids, including their side chains, and established efficient methods for 13 amino acids. Using a Pt/C-catalyzed hydrogen–deuterium exchange reactio
Dopaminergic neurons in the ventral midbrain are critical for regulating movement, cognition, and emotion. Ventral midbrain organoids can be used to model both development and diseases of the dopaminergic system, especially Parkinson’s disease. Here, we summarize recent advances and remaining challenges in developing such three-dimensional organoids from human pluripotent stem cells. We outline ho
The landscape of Alzheimer's disease (AD) and related dementias (ADRD) diagnosis is evolving rapidly, driven by advances in disease understanding, biomarker tools, and disease-modifying therapies. Modern diagnostic approaches emphasize biological precision, early detection, and dynamic frameworks that adapt to treatment-induced changes in disease biology. These frameworks enable opportunities for
Pancreatic (PC), colorectal (CRC), hepatocellular (HCC), and gallbladder (GC) cancers together account for nearly 20% of all cancer cases. However, specific biomarkers and therapeutic targets for these cancers are lacking. Diagnosing these cancers early and providing timely, appropriate treatment to improve patient outcomes is crucial. In this context, previous studies, including ours, have highli
Stuttering is a disorder characterized by transient disruptions in speech motor production. This article is focused on the characteristics of stuttering and the immediate vocal tract mechanisms resulting in stuttered speech disruptions. A range of observations from an initial series of studies on the motor characteristics of stuttering events in adults is presented, combined with a narrative revie
Objective: The aim was to resuscitate and evaluate hearts ex vivo after 22 min of cardiac arrest with the goal of increasing the number of usable hearts from controlled donation after circulatory death (cDCD). Design: Eight pigs (39–61 kg) underwent 22 min of ventricular fibrillation, after which the heart was first perfused in vivo for three minutes with an oxygenated, erythrocyte-containing card
Morphine-based analgesia is effective but can compromise donor safety. We investigated whether continuous infusion of local anesthetics (CILA) can provide sufficient pain control and reduce morbidity related to opiate analgesics after hand-assisted retroperitoneoscopic (HARS) live donor nephrectomy. Forty consecutive live kidney donors underwent HARS and were treated with the ON-Q system providing
High-spin states have been populated in [Formula Presented] via the [Formula Presented] reaction at 150 MeV, using the EUROGAM II [Formula Presented]-ray spectrometer to record high-fold [Formula Presented]-ray coincidences. A quadruples [Formula Presented]-ray analysis [Formula Presented] has been used to extend the known level scheme. In addition to several aligned noncollective states, a new hi
Background: This study aimed to assess chlamydia diagnostics in different clinic types, including internet-based self-sampling (IBSS). Furthermore, we investigated the incidence of chlamydia-associated complications. Methods: Data on Chlamydia trachomatis (CT) testing were retrieved from six healthcare regions in the years 2016–2023 across different categories of testing facilities. National data
