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Bronchial mast cells are the dominating LTC4S-expressing cells in aspirin-tolerant asthma

The increased bronchial production of leukotriene C4 (LTC4) in asthma is assumed to derive from infiltrating eosinophils expressing LTC4-synthase (LTC4S). Multicolor immunohistofluorescence examination of bronchial cryosections from 30 treated, untreated, or bronchial antigen-provoked aspirin-tolerant individuals with asthma and nine control subjects revealed that the dominating LTC4S-expressing c

Transient structural distortion of metal-free Cu/Zn superoxide dismutase triggers aberrant oligomerization.

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease linked to the misfolding of Cu/Zn superoxide dismutase (SOD1). ALS-related defects in SOD1 result in a gain of toxic function that coincides with aberrant oligomerization. The structural events triggering oligomerization have remained enigmatic, however, as is the case in other protein-misfolding diseases. Here, we target the criti

Innovation management through the use of diversity networks

A methodology for innovation and analysis in a context of complex problem spaces is presented, introducing the idea of a diversity network. The methodology draws upon a framework which puts ‘complexification’ into systemic practice. Such an application helps individual participants to outline their narratives, create and agree upon categories, and use these to classify their narratives. Clusters o

Diagnosing Parkinson by using artificial neural networks and support vector machines

Parkinson\'s Disease (PD) is the second most common neurodegenerative a�iction only surpassed by Alzheimer\'s Disease (AD). Moreover, it is expected to increase in the next decade with accelerating treatment costs as a consequence. This situation leads us towards the need to develop a Decision Support System for PD. In this paper we propose methods based on ANNs and SVMs to aid the specialist in

The objective diagnosis of vibration-induced vascular injury

For 44 patients with vibration-induced white finger and a reference group of 25 healthy men, finger systolic blood pressure (FSBP) before and after local cooling, skin temperature, and rewarming rates were determined before and after vasodilation (body warming and alcohol). An estimation of the proportions of vasopasm and organic changes was possible, and cutaneous changes could be separated from

Coadsorption of Cu(II) and glyphosate at the water-goethite (alpha-FeOOH) interface: molecular structures from FTIR and EXAFS measurements

The coadsorption of Cu(II) and glyphosate (N-(phosphonomethyl)glycine, abbreviated to PMG) at the water-goethite interface was studied by means of batch adsorption experiments, attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy, and extended X-ray absorption fine structure (EXAFS) spectroscopy. The system was investigated over the pH range 3-9 and at total concentratio

Head movement restriction and postural stability in patients with compensated unilateral vestibular loss

OBJECTIVE: To study whether restriction of head-neck movements improves postural performance in patients with compensated unilateral total vestibular loss. DESIGN: Randomized controlled experimental study. SETTING: Laboratory for clinical and experimental vestibular testing at a tertiary referral center. PATIENTS: Fifteen consecutive patients (seven men, eight women, mean age 53 years) at routine

Sexual risk behaviour in women carriers of Mycoplasma hominis

OBJECTIVE: To study the sexual behaviour of women harbouring Mycoplasma hominis in the vagina. SETTING: Two family planning clinics and a youth clinic for contraceptive advice. METHODS: The vaginal flora of 996 women were investigated microbiologically, including culturing for M. hominis from the posterior vaginal fornix. Cultures and tests were also made to diagnose genital Chlamydia trachomatis

The Swedish Academy of Sciences: Language policy and language practice

The Swedish Academy of Sciences was founded in 1739. The article presents and discusses the explicit language policy of the academy and analyzes some aspects of the language and rhetoric of the transactions (in Swedish) of the academy:textual organization, objectivity, rhetorical devices, lexical apparatus, syntactic machinery and techniques of presentation. Special interest is devoted to the tran

Spatially and temporally resolved electron density measurements in streamers in dielectric liquids

Spatially and temporally resolved spectroscopic measurements of light emitted from positive streamers in transformer oil are presented. Analyses of the measurements performed with a DC needle-plane gap yield electron densities and indications of the atomic excitation temperatures in the streamers. The hydrogen emission reveals an electron density below 10(16) cm(-3) during the main part of the str

Spectroscopic measurements of streamer filaments in electric breakdown in a dielectric liquid

Emission spectroscopy has been utilized to provide information about the electron density and temperature in streamers and breakdown arcs in transformer oil. Recorded spectra include strongly broadened hydrogen Balmer-alpha lines and vibration/rotation band profiles of the C-2 molecule. The origin of the observed broadening of hydrogen lines is discussed and it is concluded that it arises mainly f

Measurements of excited state lifetimes and oscillator strengths in Pt II

We report on radiative lifetime measurements of short-lived states in singly ionized platinum by excitation with pico-second laser pulses and subsequent time-resolved detection. The upper levels were populated from metastable ion levels in a laser-generated plasma using radiation in the UV/VUV spectral range. The following lifetimes were obtained: tau(5d(8)(F-3(4))6p(1/2), J = 7/2) = 3.9(3) ns, ta