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Chemical cross-linking was used to analyze the binding sites for the agonist bradykinin (BK) and the antagonists NPC17731 and HOE140 on the bovine B2 bradykinin receptor. [3H]BK and [3H]NPC17731 bound with high affinity to the same B2 receptor in bovine myometrial membranes as determined by the total number of specific binding sites and pharmacological specificity of the binding of these two radio

Chronic obstructive pulmonary disease (COPD) affects the lives of an ever-growing number of people worldwide. The lack of understanding surrounding the pathophysiology of the disease and its progression has led to COPD becoming the third leading cause of death worldwide. COPD is incurable, with current treatments only addressing associated symptoms and sometimes slowing its progression, thus highl

During spring and autumn a special thermohydrodynamic phenomenon, called a thermal bar, can be observed in dimictic lakes. [A dimictic lake is a lake where a complete turnover of the water occurs twice a year (in spring and autumn).] The thermal bar is a zone of mixing that separates waters with temperatures above and below 4° C. Its practical importance is due to the possibility that it might iso

The present article is a study of the surface temperature distribution and its evolution during spring in Lake Ladoga, using NOAA-AVHRR Channel 4/Channel 5 (CH4/CH5) data, with special focus on a thermohydrodynamic phenomenon, called thermal bar. The split-window technique, where both constant and atmospheric-mass-dependent retrieval coefficients are tested, is used for calculating the atmospheric

ObjectiveWe examine the impact of stepfamily exposure on the educational outcomes of children, considering factors such as age at stepfamily formation, gender of the stepparent, presence of step/half-siblings, and the stepparent's socioeconomic resources.BackgroundThe prevalence of stepfamilies across the Global North highlights the urgency of the issue. Despite a sizeable existing empirical liter

Joel Penney made an innovative, interdisciplinary intervention into the scholarship on political participation with The Citizen Marketer: Promoting Political Opinion in the Social Media Age. By melding modern marketing frameworks with democratic theory, Penney offered a timely heuristic for rethinking citizens’ engagement with politics on social media. The “citizen marketer approach” developed in

This short response does two things. First, it argues that urban benchmarks have specific and structural limits not identified in the principal essay in this intervention, which curtail the kinds of constructive and critical work such benchmarks might be expected to perform. ISO 37120 is discussed as an example. Second, it proposes a pluralistic approach to engagement and offers six suggestions fo

Promoting a more sustainable development of urban realities is one of the most important goals of the recent decades. One possible strategy to undertake in order to achieve this objective is the implementation of a road pricing: tolling private cars when passing by certain roads of the network could be a way to tone down the traffic congestion and, at the same time, encourage the shifting towards