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Inhibitory effects of BCG on adenovirus tumorigenesis : Dependence on administration schedule

The cumulative incidence of tumours was registered in CBA mice inoculated with adenovirus type 12 when newborn and treated with BCG in different ways during the latency period. A single subcutaneous dose of BCG at 3–4 weeks of age had a preventive effect, while no prevention could be recorded after a single BCG dose at 9 weeks of age or eight BCG injections at intervals of 1 week. Sera obtained du

Demonstration of two group‐specific TSTAs in adenovirus‐induced tumors

Infection of mice and rats with any one of five tested human adenovirus types belonging to groups A and B (types 3, 7, 12, 18 and 31) induced an immunity to the TSTAs of type 12 tumors as detected by the colony inhibition (CI) test. No immunity was found against an adenovirus type 1 tumor. Two adenovirus types belonging to group C (types 1 and 5) were similarly tested and found to induce a clear‐c

Cross‐reacting tstas in adeno 7 and 12 tumors demonstrated by 51CR‐Cytotoxicity and isograft rejection tests

Antisera of mice hyperimmunized against syngeneic X‐irradiated adeno 12 tumor cells were tested for complement‐dependent cytotoxicity against an adeno 7 and an adeno 12 hamster tumor by a 51Cr‐cytotoxic test, developed to work on non‐lymphoid target cells. Significant isotope release above the level of release obtained after exposure to control sera was recorded with both tumors. There was no simi

Axon morphology is modulated by the local environment and impacts the noninvasive investigation of its structure-function relationship

Axonal conduction velocity, which ensures efficient function of the brain network, is related to axon diameter. Noninvasive, in vivo axon diameter estimates can be made with diffusion magnetic resonance imaging, but the technique requires three-dimensional (3D) validation. Here, high-resolution, 3D synchrotron X-ray nano-holotomography images of white matter samples from the corpus callosum of a m

Possibly specific immune complexes in sera of patients with untreated acute myelogenous leukemia

Eleven patients with acute myelogenous leukemia (AML) in the acute stage of the disease were studied. Sera of seven patients were assayed for complement‐dependent cytotoxicity to autochthonous AML cells and sera of four patients were tested with allogeneic target cells before and after ultrafiltration at low pH. No specific cytotoxic activity could be detected in any untreated sera. Ultrafiltratio

A rare case of IgE kappa monoclonal gammopathy of undetermined significance identified in a Swedish female

Monoclonal gammopathies involving immunoglobulin E (IgE) is a very rare phenomenon, with less than 70 cases being previously described in the literature. The IgE monoclonal gammopathies include malignant plasma cell disorders such as IgE multiple myeloma (MM), as well as the associated premalignant condition IgE monoclonal gammopathy of undetermined significance (MGUS). We report a case of a 41-ye

Stress and health among women and men in a Swedish telecom company

The aim of the study was to investigate gender differences at managerial and non-managerial level in perceived stress and control and the relationship to health problems. Questionnaires were collected from 281 women and men at both managerial and non-managerial level in a sales department in a large Swedish telecom company. The results showed only minor differences in perceived stress and no diffe

The strategic process and its impact on the outcome of a tender

A competitive tendering process within a public organization does not always render the anticipated results, i.e., the intended strategy is not always realized. This paper shows that the way the strategy process is managed by the parties involved in the tender is of importance to the outcome. Previous research has mainly focused on the situation ex ante the tendering process. This paper contribute

Divergence of Hoxc8 early enhancer parallels diverged axial morphologies between mammals and fishes

There is considerable interest in understanding how cis-regulatory modifications drive morphological changes across species. Because developmental regulatory genes, including Hox genes, are remarkably conserved, their noncoding regulatory regions are likely sources for variations. Modifications of Hox cis-regulatory elements have potential to alter Hox gene expression and, hence, axial morphologie

Occupational engagement in persons with schizophrenia: relationships to self-related variables, psychopathology, and quality of life.

Previous research suggests that having schizophrenia involves not being fully equipped to engage in daily occupations. This study was aimed at exploring relationships between occupational engagement and the issues of self-related variables, psychiatric symptoms, and quality of life. Seventy-four outpatients with schizophrenia entered the study. Instruments used in this study were Profile of Occupa

Changes in mucociliary activity may be used to investigate the airway-irritating potency of volatile anaesthetics

We have examined the short-term effects of three volatile anaesthetics, halothane, isoflurane and desflurane, on mucociliary activity in the rabbit maxillary sinus in vivo. Mucociliary activity was recorded photoelectrically and the signal processed by fast Fourier transformation. Administration of 1.0 MAC of halothane, isoflurane or desflurane caused a temporary increase in mucociliary activity,

Effect of high-temperature drying on properties of Norway spruce and larch

Abstract in German Bei der Holztrocknung können Änderungen der Holzeigenschaften aufgrund von Behandlungstemperatur und -dauer auftreten. Erhöhte Trocknungstemperaturen führen im Allgemeinen zu einer Verkürzung der Trockendauer und einer negativen Beeinflussung einiger Eigenschaften. Die vorliegende Studie behandelt die Auswirkung unterschiedlicher Trocknungstemperaturen (80, 120 und 170 °C) auf GIn timber drying, mechanical properties may be changed due to treatment temperature and treatment duration. In general, when increasing the kiln temperature, drying time is decreased and some timber properties are negatively affected. In this study, the effect of different drying temperatures (80, 120 and 170 degrees C) on equilibrium moisture content and sorption rate, on bending strength and sti

Transcription factor profiling in individual hematopoietic progenitors by digital RT-PCR

We report here a systematic, quantitative population analysis of transcription factor expression within developmental progenitors, made possible by a microfluidic chip-based "digital RT-PCR" assay that can count template molecules in cDNA samples prepared from single cells. In a survey encompassing five classes of early hematopoietic precursor, we found markedly heterogeneous expression of the tra

A microcalorimetric study of water vapor sorption on morphine sulphate

Water vapor sorption on morphine sulphate was studied in a twin double sorption microcalorimeter at 25°C. The vapor sorption isotherm and the differential heats of sorption were determined simultaneously from dry condition to a water activity of 0.99. Two well resolved hydration steps were obtained on the sorption isotherm at water activities of 0.01 and 0.22 corresponding to the formation of dihy