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Background: The data concerning the effects and safety of androgen in human breast tissue are conflicting. Objective: Our aim was to analyze the effects of androgens on normal human breast tissue (HBT). Approach: We cultured explants of HBT (obtained from reduction mammoplasty operations of postmenopausal women) with or without testosterone (T) and 5α-dihydrotestosterone (DHT) or in combination

During asthma exacerbations, increased airway inflammation may impair the effects of beta(2)-adrenoceptor (beta(2)AR) agonists. It is unclear whether this impairment is prevented by inhaled glucocorticoids (GCs). We have investigated the relaxation of carbachol-contracted mouse tracheal segments to the beta(2)AR agonists formoterol, terbutaline, and salmeterol. The segments were pre-exposed for 4

Biological soft tissues exhibit non-linear complex properties, the quantification of which presents a challenge. Nevertheless, these properties, such as skin anisotropy, highly influence different processes that occur in soft tissues, for instance wound healing, and thus its correct identification and quantification is crucial to understand them. Experimental and computational works are required i

Popular Abstract in Swedish Frisöryrket har en lång historia av stolta yrkesutövare, men frisörer arbetar i en komplex arbetsmiljö, där de utsätts för olika risker, inte bara luftvägsbesvär, utan även handeksem, muskelrelaterade besvär, stress, och ögonbesvär. I Sverige är 85 - 90 % av frisörerna kvinnor, varav de flesta är egenföretagare antingen som ensamägare till en salong eller tillsammans meLittle is known of respiratory symptoms in female hairdressers, and of the impact on the health-related quality of life (HRQoL), nor of knowledge of their own views on preventive work. The aim of this thesis was to examine the occurrence of asthma, symptoms and mechanism of bleaching-associated nasal symptoms, the effects on HRQoL and how young hairdressers reason about the work environment. A m

Background and objectives Multi-institutional quality improvement registries (QI registries) are a promising approach to quality improvement. They are also used for clinical research, public quality reporting and other valuable purposes. The aim of this study was to identify elements and outcomes of national policies to promote registries in Sweden and to compare them with recent policies in the U

Context Agile software development has become popular in the past decade without being sufficiently defined. The Agile principles can be instantiated differently which creates different perceptions of Agility. This has resulted in several frameworks being presented in the research literature to evaluate the level of Agility. However, the evidence of their actual use in practice is limited. Objec

Within the series of articles investigating the burden of rheumatoid arthritis (RA), this paper reviews the methods used for economic assessment of the RA treatments by HTA agencies and other bodies involved in cost-effectiveness analysis and the current status of the field. The overall methods, as well as the challenges, of cost-effectiveness analysis in RA are common to all chronic progressive d

An increasing demand for both formal and informal care is likely to result from the ongoing demographic transition at the same time as there is a further move away from the traditional domestic division of labour. Public policy-making that aims at increasing the supply of informal care necessitates knowledge about the relative importance of various incentives for individual care providers. This pa

Systematic representation of information related to genetic and non-genetic variations is required to allow large scale studies, data mining and data integration, and to make it possible to reveal novel relationships between genotype and phenotype. Although lots of variation data is available it is often difficult to use due to lack of systematics.

This article presents an analysis of a group of converts to Roman Catholicism, hitherto largely unknown in historical research, of Scandinavian origin received in the late 17th and early 18th centuries in Rome by Ospizio dei Convertendi. The article provides an overview of the converts and their motives, examining different factors which influenced the complex conversion process. It suggests that

In this paper we construct ternary q-Virasoro-Witt algebras which q-deform the ternary Virasoro-Witt algebras constructed by Curtright, Fairlie and Zachos using su(1, 1) enveloping algebra techniques. The ternary Virasoro-Witt algebras constructed by Curtright, Fairlie and Zachos depend on a parameter and are not Nambu-Lie algebras for all but finitely many values of this parameter. For the parame