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Popular Abstract in Swedish Förr trodde man att de delar av genomet som inte uttrycks till proteiner är oviktiga, eftersom man trodde att det nästan uteslutande är proteinerna som utför de nödvändiga funktionerna i cellen. Man kände till att DNA och RNA innehåller information om hur proteiner ska se ut och när de ska uttryckas, men man kände bara till ett fåtal andra uppgifter som RNA har i cellenThe complex genetics of cancer allows tumors to grow and spread undeterred by the control mechanisms of the cell. The importance of protein-coding genes in tumorigenesis is well established. Recently, microRNAs (miRNAs) have emerge as key regulator of development and cellular processes such as differentiation, cell growth and cell death; processes closely linked to cancer. The aim of this thesis w

ObjectivesTransdiagnostic models aim to uncover shared mechanisms across mental disorders. Reward responsiveness (the ability to experience pleasure from rewarding stimuli) is a plausible, yet underexplored, transdiagnostic mechanism linking obsessive-compulsive disorder (OCD) and depression. This study used network analysis to (1) examine how key reward responsiveness domains are interlinked in i

Motivationen med studien var den alldeles för höga stråldosen som används vid CTundersökningar. I de allra flesta fallen anpassas man inte rörströmmen efter patientens storlek och därmed får smalare patienter en onödigt hög stråldos. Målet var att reducera stråldosen till patienter som undersöks med datortomografi utan att minska på bildkvalité, genom att anpassa rörströmmen efter patientens stoIn this study we have investigated the possibilities of dose reduction in CT at a constant level of image quality by adjustment of the tube current to the phantom size. The motivation with the study is the high radiation doses to the patients and the increasing frequency of CT examinations and the variety of examinations in CT, and that the same tube current is used for different patient sizes. Ac

Popular Abstract in Swedish Ämnen i bröstmjölk kan få cancerceller att begå självmord - in vivo effekter och mekanismer för celldöd Sedan länge är det känt att bröstmjölk skyddar det ammande barnet mot infektioner och hjälper till att bygga upp des's immunförsvar. Ett skyddande ämne som kan bilda's av molekyler från bröstmjölk är HAMLET (human alpha-lactalbumin made lethal to tumor cell's), som kHAMLET (human alpha-lactalbumin made lethal to tumor cells), a molecular complex derived from human milk, is an interesting new tool in cancer research since it induces programmed cell death in tumor cells while leaving normal, differentiated cells unharmed. The in vivo effects of HAMLET were studied in a rat xenograft model of human glioblastoma. HAMLET reduced the tumor volume and delayed the o

Modern cellular radio base stations (RBS) employ beamforming to dynamically steer radio frequency (RF) energy toward active users. This adaptive transmission produces significant angular and temporal variations in the equivalent isotropically radiated power (EIRP). To account for these variations, electromagnetic field (EMF) compliance assessment of RBSs rely on the usage of the EIRP envelope toge

Denna uppsats undersöker unboxingvideor på TikTok som en del av influencers strategier för att balansera autenticitet och kommersiella intressen. Genom att analysera fem sponsrade unboxingvideor samt publikens kommentarer belyser studien hur interaktionerna bidrar till att skapa, förstärka och ibland även utmana influencers varumärke. Med utgångspunkt i teorier om deltagarkultur, parasociala relat

Background: Mammography screening programmes have been widely implemented across European countries over the past 40 years with the main aim to detect breast cancer earlier and thereby reduce breast cancer mortality. This study aimed to analyse and compare changes over time in breast cancer incidence, by stage at diagnosis, and breast cancer mortality across countries in relation to the timing of

Orbit integration for three different assumed Intermediate-mass Black Hole (IMBH, defined as black holes with mass MBH in the range 100Mo < MBH 104Mo) populations in the Milky Way for 10 Gyr has been performed. Upon collision with molecular clouds in the galactic disc, the relative velocity between both objects has been measured and the luminosity resulting from the gas accretion process onto the

This thesis is an analysis of contemporary Manga Culture in Japan and Sweden. The objective of the study was to identify the potential and problems for Manga culture and its future in the international market. Also I try to examine the potential of Manga to establish its academic status. This research will be based on the analysis of the transition and features of Manga related with Japanese cultu

This master’s thesis examines the motives of non-aligned, geographically peripheral and smaller European Union (EU) Member States (MS) Finland, Sweden and Ireland to participate in EU military crisis management operations. It also studies the effects that these MS have had in the development of the Common Security and Defence Policy (CSDP). Theoretically this thesis is based on a typology that Aly

By using the variables politics of scale, politics of position and politics of place, the dispute concerning the hydropower plant Rogun between the upstream country of Tajikistan and the downstream country of Uzbekistan can be explained from three spatial angels. The Rogun dates back to the Soviet era and under recent times the relations between Tajikistan and Uzbekistan have become tense since Ro

Den här uppsatsen undersöker människors nyhetskonsumtion vid en krissituation i kontrast till vardagslivets nyhetsanvändning med utgångspunkt i jodelhotet mot Lunds universitet. För att få en förståelse för vad som sker med konsumtionen när vardagslivet krackelerar och en kris infinner sig har vi genomfört en kvalitativ publikstudie. För att förklara detta växelspel i konsumtionen har vi tagit sta

The intestinal lamina propria (LP) contains distinct subsets of classical dendritic cells (cDC), each playing key non-redundant roles in intestinal immune homeostasis. Here, we show that glycoprotein 2 (GP2), a GPI-anchored protein and receptor for bacterial type-I fimbriae, is selectively expressed by CD103+CD11b+ cDC in the murine small intestine (SI). GP2 expression was induced on CD103+CD11b+

BackgroundMultigene expression assays for molecular subtypes and biomarkers can aid clinical management of early invasive breast cancer. Based on RNA-sequencing we aimed to develop single-sample predictor (SSP) models for conventional clinical markers, molecular intrinsic subtype and risk of recurrence (ROR).MethodsA uniformly accrued breast cancer cohort of 7743 patients with RNA-sequencing data

As found in the health studies literature, the levels of climate association between epidemiological diseases have been found to vary across regions. Therefore, it seems reasonable to allow for the possibility that relationships might vary spatially within regions. We implemented the geographically weighted random forest (GWRF) machine learning method to analyze ecological disease patterns caused

Communication between cells located in different parts of an organism is often mediated by membrane-enveloped nanoparticles, such as extracellular vesicles (EVs). EV binding and cell uptake mechanisms depend on the heterogeneous composition of the EV membrane. From a colloidal perspective, the EV membrane interacts with other biological interfaces via both specific and non-specific interactions, w

Background In patients with GTP-cyclohydrolase deficient dopa-responsive dystonia (DRD) the occurrence of associated non-motor symptoms (NMS) is to be expected. Earlier studies report conflicting results with regard to the nature and severity of NMS. The aim of our study was to investigate the prevalence of psychiatric disorders, sleep problems, fatigue and health-related quality of life (HR-QoL)