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Collagen type II-specific monoclonal antibody-induced arthritis in mice - Description of the disease and the influence of age, sex, and genes

Transfer of collagen type H (CH)-specific monoclonal antibodies induces an acute form of arthritis (collagen type H antibody-induced arthritis, CAIA) in nave mice. Arthritis was induced using a pair of monoclonal antibodies M2139 and CIIC1, binding to J1 and C1(I) epitopes of CH, respectively. Thereafter, lipopolysaccharide injection was used to increase the incidence and severity of the disease.

Coupling of methyl and total mercury in a minerotrophic peat bog in southeastern Sweden

During most of an annual cycle, we studied the temporal variation of total mercury (Hg-T) and methyl mercury (MeHg) in unfiltered and filtered (0.45 mu) peat water from a minerotrophic peat bog in southeastern Sweden. MeHg in bulk water ([MeHgT]) and total Hg in filtered water in discharge water from the peat bog ([Hg-D]) were an order of magnitude higher than in upland runoff water entering the p

Altered swallowing function in elderly patients without dysphagia: radiologic findings in 56 cases

Swallowing disorder is an increasing problem in our aging population. A majority of these patients have a functional abnormality of the oral, pharyngeal, and/or esophageal stage of swallowing. However, what constitutes normalcy is not well understood, and baseline swallowing in elderly persons without dysphagia has not been adequately described. We therefore evaluated 56 persons with a mean age of

Transport asymmetry in peritoneal dialysis: application of a serial heteroporous peritoneal membrane model

The transport of macromolecules during peritoneal dialysis is highly selective when they move from blood to dialysate but nearly completely unselective in the opposite direction. Aiming at describing this asymmetry, we modeled the peritoneal barrier as a series arrangement of two heteroporous membranes. First a three-pore membrane was considered, crossed by small [radius of the small pore (r(s)) a

Does Foreign Direct Investment Replace Home Country Investment? The effect of European Integration on the Location of Swedish Investment

The purpose of this article is to examine the effects of European integration on the location of investments by Swedish multinational corporations (MNCs). Evidence is presented about the extent to which European integration has attracted investment by Swedish MNCs, and whether foreign direct investment (FDI) is being undertaken at the expense of home country investment. In the empirical analysis,

A novel rating scale to predict maximal exercise capacity.

To predict maximal exercise capacity, we have developed the rating of perceived capacity (RPC) scale, based on metabolic equivalents (METs). MET values from 1 to 20 were listed on a progressive scale and linked to physical activities. Test subjects rated their perceived capacity by choosing the most strenuous activity and the corresponding MET value that they could sustain for 30 min. In order to

Microfungi in coniferous forest soils treated with lime or wood ash

Microfungal species composition was studied in coniferous forest soils which had been treated with lime or wood ash. The pH increased by about 2.5 units at the highest rate of application. Fungi were isolated 4–5 years after the treatments using a soil washing technique. At one site, Öringe, clear differences in species composition due to liming were found. Penicillium spinulosum, Oidiodendron cf.

Cross-linked N-telopeptide of type I collagen (NTx) in urine as a predictor of periprosthetic osteolysis.

Periprosthetic osteolysis is often nonsymptomatic and hard to visualize by conventional radiography. Cross-linked N-telopeptide of type I collagen (NTx), a marker of osteoclast mediated bone resorption, has been suggested to evaluate local particulate-induced osteolysis in patients operated on with a total hip prosthesis. Urine specimens were sampled after hip joint replacement in 160 patients. NT

The family as the health producer--when spouses act strategically.

The Grossman model has been extended recently in order to take account of the fact that most people lead their lives in a family--using frameworks in which family members, respectively, (a) have common preferences and (b) are Nash-bargainers. These models, however, do not consider individual incentives for behaving strategically. In the model presented in this paper, spouses interact strategically

Molecular engineering of biotin-glutamic acid decarboxylase 65 fusion protein (Biotin-GAD65) for non-radioactive GAD65 antibody assay

We constructed biotinylated fusion proteins that linked to three detection tags to GAD65 at the N-terminus, and expressed them in an E. coli expression system. The Biotin14-GAD65 protein exhibited the strongest binding to both the GAD65 antibody and the streptavidin among the three constructs. We describe the optimal conditions using a Biotin14-GAD65-based immunoassay for the detection of GAD65 an

A randomized trial of basing treatment on human papillomavirus and/or cytology results in low-grade cervical lesion triage

OBJECTIVE: This study was undertaken to compare management algorithms that base treatment with loop electrosurgical excision procedure on human papillomavirus and/or repeat Papanicolaou test smear results. STUDY DESIGN: A randomized trial that referred 674 women with either atypical squamous cells of undetermined significance or low-grade squamous intraepithelial lesions cytology results, detected

Missing values in peer assessment of social behavior using the RCP

This article deals with probable causes for missing values when using the Revised Class Play instrument for peer assessment of social behavior. The study was conducted with 10-13 year old primary school children in Sweden. The findings reveal that missing values may be caused by the cognitive and linquistic complexity of the instrument (RCP), as well as by gender stereotypes. The results indicated

Relations between coping strategies and health-related quality of life in patients with spinal cord lesion

Objective: Although the use of appropriate coping strategies has been suggested to be a key factor in determining successful adjustment to severe physical illness/disability, little systematic support for this link has been found. We investigated relationships between spinal cord lesion-related coping strategies and health-related quality of life when studying for sociodemographic, disability-rela

Immigrant language groups in Religious Organisations

During the process of migration, many immigrants undergo a number of changes in their relationships to their religious organisations. One factor that has emerged as especially important in immigrants’ congregational affiliation is the availability of language groups in immigrants’ mother tongues. This article examines how these groups are formed and the roles they play in the lives of their member

Self-concept and introversion in adolescents with cleft lip and palate.

The purpose of this study was to investigate if adolescents with cleft lip, or palate, or both (CLP), have an altered self-concept, and to assess their degree of introversion, compared with a control group. The CLP group consisted of 55 adolescents (aged 17-20 years) and the control group consisted of 31 adolescents (16-19 years). The Tennessee Self Concept Scale (TSCS) was used to measure the sub

A mechanical stretch induces contractile activation in unstimulated developing rat skeletal muscle in vitro

The effects of a stretch-release cycle (25 of the resting muscle fibre length, Lo) on both tension and [Ca2+i in small, unstimulated, intact muscle fibre bundles isolated from adult and neonatal rats were investigated at 20 C. The results show that the effects of the length change depended on the age of the rats. Thus, the length change produced three effects in the neonatal rat muscle fibre bundl