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In the body, all cell surfaces are covered with glycans, and many regulatory components havecarbohydrates attached to them, which can aid in their function. Galectins are a family of proteins whichcan bind to specific glycans and oligosaccharides and cross-link them to influence a wide range of cellularprocesses. The members of the galectin family are structurally similar and can be involved in th
This study aimed to investigate how 6-bromoindirubin-3’-oxime (BIO) increases the osteogenic differentiation of canine bone mesenchymal stem cells (BMSCs) and the role of the Wnt/β-catenin signaling pathway in this process. We mimicked the effect of Wnt by adding BIO to the culture medium of BMSCs and examined whether canonical Wnt signaling positively affects the differentiation of these cells in
Combinations of theology and anthropology have been criticized for losing track of what theology ought to be about. Yet this loss might be precisely what enables scholars to understand political practices which point towards that which escapes both the theological and the anthropological grasp—a pointer which could be crucial to fashion solidarities that connect faiths in the pursuit of justice.
Context. Ultra-short-period planets (USPs) are a unique class of super-Earths with an orbital period of less than a day, and hence they are subject to intense radiation from their host star. These planets cannot retain a primordial H/He atmosphere, and most of them are indeed consistent with being bare rocky cores. A few USPs, however, show evidence for a heavyweight envelope, which could be a wat
This thesis presents fundamental studies on oxide-based catalysts and model catalysts used for the synthesis of renewable fuels. The two investigated oxide catalysts are In2O3(111) model catalysts and NiMo-oxide catalysts.The In2O3(111) surface is studied as a model system for In2O3-based catalysts used for CO2 hydrogenation to methanol. Specifically, the interaction of In2O3(111) with CO2, syngas
Natural selection generally favours phenotypic variability in camouflaged organisms, whereas aposematic organisms are expected to evolve a more uniform warning coloration. However, no comprehensive analysis of the phenotypic consequences of predator selection in aposematic and cryptic species exists. Using state-of-the-art image analysis, we examine 2800 wing images of 82 moth species accessed via
This clinical workshop is aimed at child and adolescent mental health professionals. The workshop will focus on two interventions found in all first-line, evidence-based treatments for PTSD: exposure to the trauma memory and reminders, and cognitive restructuring of trauma-related beliefs. Participants will learn about the various way that effective exposure can be achieved through writing, oral r
Current food systems pose one of the greatest health and environmental challenges of the21st century. A systemic shift in the food sector can be accelerated by technologies and innovations,such as seaweed food applications. However, introducing and expanding seaweed as a food resourceinto Western markets comes with several challenges.These challenges include its microbial, chemical, and sensory qu
Poor management and excessive pumping of groundwater (GW) resources can lead to a significant decline in GW level, which may result in land deformation and compaction of compressible fine-grained soils within or adjacent to the aquifer. Soil compaction and resulting land deformation may be permanent if the GW level declines beyond the maximum historical stress. In extreme cases, the aquifer may lo
Disease staging, whereby the spatial extent and load of brain pathology are used to estimate the severity of Alzheimer disease (AD), is pivotal to the gold-standard neuropathological diagnosis of AD. Current in vivo diagnostic frameworks for AD are based on abnormal concentrations of amyloid-β and tau in the cerebrospinal fluid or on PET scans, and breakthroughs in molecular imaging have opened up
An amplitude analysis of the B0→K∗0μ+μ- decay is presented. The analysis is based on data collected by the LHCb experiment from proton-proton collisions at s=7, 8 and 13 TeV, corresponding to an integrated luminosity of 4.7 fb-1. For the first time, Wilson coefficients and nonlocal hadronic contributions are accessed directly from the unbinned data, where the latter are parametrized as a function
Similar to systematic reviews (SRs) in clinical fields, preclinical SRs address a specific research area, furnishing information on current knowledge, possible gaps, and potential methodological flaws of study design, conduct, and report. One of the main goals of preclinical SRs is to identify aspiring treatment strategies and evaluate if currently available data is solid enough to translate to cl
The magnetic structure of Fe5O6 is studied using a combination of the group-theoretical analysis and DFT + U calculations of the electronic spectrum. The calculations are performed for the magnetic k = (0, 0, 0) vector. The magnetic ground state corresponds to the orthogonal ordering of two magnetic subsystems: the magnetic moments of Fe2+/Fe3+ ions located at the octahedral sites (slabs of octahe
Certain oxygenated compounds, when blended with gasoline, have the ability to inhibit the occurrence and decrease the intensity of engine knock, helping improve engine efficiency. Although ethanol has had widespread use as an oxygenate, higher alcohols, such as butanol, exhibit superior properties in some respects. Besides alcohols, glycerol derivatives such as glycerol tert-butyl ether (GTBE), am
Kataegis is a hypermutation phenomenon characterized by localized clusters of single base pair substitution (SBS) reported in multiple cancer types. Despite a high frequency in breast cancer, large-scale analyses of kataegis patterns and associations with clinicopathological and molecular variables in established breast cancer subgroups are lacking. Therefore, WGS profiled primary breast cancers (
Importance: Clonal hematopoiesis of indeterminate potential (CHIP) may contribute to the risk of atrial fibrillation (AF) through its association with inflammation and cardiac remodeling. Objective: To determine whether CHIP was associated with AF, inflammatory and cardiac biomarkers, and cardiac structural changes. Design, Setting, and Participants: This was a population-based, prospective cohort
CO2 management, capturing CO2 from industry processes or removing CO2 from the atmosphere, is increasingly presented as a necessity for climate. Scandinavian countries are at the forefront of developing carbon capture and storage (CCS) technology. We reviewed the scientific literature on CCS in Scandinavia to identify and analyse prevalent imaginaries for the role of this technology in the region.
Fluorescent probes have become promising tools for monitoring the concentration of peroxynitrite, which is linked to many diseases. However, despite focusing on developing numerous peroxynitrite based fluorescent probes, limited emphasis is placed on their sensing mechanism. Here, we investigated the sensing mechanism of a peroxynitrite fluorescent probe, named BHID-Bpin, with a focus on the relev
