Sökresultat

Abstract is not available

Background: Gene duplication followed by the functional divergence of the resulting pair of paralogous proteins is a major force shaping molecular networks in living organisms. Recent species-wide data for protein-protein interactions and transcriptional regulations allow us to assess the effect of gene duplication on robustness and plasticity of these molecular networks. Results: We demonstrate t

Elongation factor P is a universally conserved protein stimulating peptidyltransferase activity during protein synthesis. The factor is sensitive to classical inhibitors of the ribosomal peptidyltransferase activity and is possibly involved in alignment of the substrate tRNAs in the catalytic centre of 70S ribosomes. Elongation factor P from the thermophilic Aquifex aeolicus was overexpressed as a

A group of Swedish oncologists and hospital physicists have estimated the number of patients in Sweden suitable for proton beam therapy. The estimations have been based on current statistics of tumour incidence, number of patients potentially eligible for radiation treatment, scientific support from clinical trials and model dose planning studies and knowledge of the dose-response relations of dif

Steady-state and transient-state kinetic experiments have been performed to test the proposal that there is a direct (channelled) transfer of NADH from glyceraldehyde-3-phosphate dehydrogenase to alcohol dehydrogenase. The results lend no support to this proposal, but can be best explained in terms of a free-diffusion mechanism for NADH transfer between the two enzymes.

Twenty M protein-positive and eight M protein-negative strains of group A streptococci were investigated with respect to surface hydrophobicity and amount of lipoteichoic acid (LTA). Surface hydrophobicity as determined in polymer two-phase systems varied substantially between individual strains and there was no correlation to the presence of antiphagocytic M protein. The amount of LTA on the surf

The aim of this study is to investigate whether current statistics can quantify the benefits of fire brigades. A detailed investigation by the London Fire Brigade of most fires in the greater London area has been underway since 1994. The present study concerns 307 fires in non-residential buildings between 1994 and 1997. Times to detection, to arrival of the fire brigade, and to extinguishment of

We recently identified a candidate tumor suppressor gene, HIN-1, that is silenced due to methylation in the majority of sporadic breast carcinomas and is localized to 5q33-qter, an area frequently lost in BRCA1 tumors and thought to harbor a BRCA1 modifier gene. To establish whether germ-line mutations in HIN-1 may influence breast cancer risk, we sequenced the HIN-1 coding region in 10 familial b

Background: The availability of high throughput methods for measurement of mRNA concentrations makes the reliability of conclusions drawn from the data and global quality control of samples and hybridization important issues. We address these issues by an information theoretic approach, applied to discretized expression values in replicated gene expression data. Results: Our approach yields a quan

[abstract missing]

The location of lipoprotein lipase activity in rat adipose tissue was studied using intact epididymal fat pads, isolated adipocytes, and lipoprotein lipase activity secreted from adipocytes as enzyme sources. The enzyme activities of these preparations were characterized by gel filtration. The method used for isolation of adipocytes had been modified to minimize activation of lipoprotein lipase du

Objective To detect possible sources of bias in ultrasound prediction of gestational age. Subjects and Methods Using the Swedish Medical Birth Registry, 571 617 women were identified who were delivered between 1990 and 1997 and who had obtainable information on last menstrual period and expected date of delivery according to ultrasound. Results Male fetuses were more likely than females to be judg

The Lamperti transformation of a self-similar process is a strictly stationary process. In particular, the fractional Brownian motion transforms to the second order stationary Gaussian process. This process is represented as a series of independent processes. The terms of this series are Ornstein-Uhlenbeck processes if $H<1/2$, and linear combinations of two dependent Ornstein-Uhlenbeck processes

We describe two new variants of the recently identified hexa-EF-hand calcium binding protein secretagogin. The first variant (secretagogin-R22) is characterized by one single amino acid exchange (Q/R) at codon 22, most likely due to RNA editing. The second variant of secretagogin (setagin) consists of 49 amino acids. Due to a frame shift, only the first 27 amino acids are identical to secretagogin

hree different types of bituminous coal were subjected to microbial desulphurization in bench scale slurry reactors. Consecutive treatment with two microorganism species was used to test if different sulphur forms could be removed. The treatment started with the bacterium Thiobacillus ferrooxidans followed by the archaeon Acidianus brierleyi. Consecutive treatment did not desulphurize the three te

In an investigation by the Swedish Cancer Society, the present status, critical issues and future aspects and potentials were described by an expert group for each of nine major areas of radiation therapy research. The present report deals with the potential of proton and light ion beams in radiotherapy.

As cardiovascular diseases have been the most common cause of mortality in the western world for decades, the demand for appropriate diagnostic methods is obvious. To facilitate the examination non-invasive methods are preferable since they do not require sensors within the circulation system. Ultrasonic Doppler is a frequently used technique in non-invasive hemodynamic studies. To increase the a

[abstract missing]