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The metabolism of pyruvate in the cell is abnormally regulated in several human diseases, such as type-II diabetes, cancer and neurodegenerative disorders, in which the human mitochondrial pyruvate carrier (HuMPC) sits at a pivotal point. It transports pyruvate across the inner mitochondrial membrane and consists of two proteins, MPC1 and MPC2, and is a potential drug target against these diseases
As environmental pressures mount, the corporate world is steering towards green information systems (IS) to respond to sustainability predicaments. This study uncovers financial stakeholders' attitudes towards the benefits and challenges of environmental and carbon management systems (ECMS) initiatives, as well as transformative green IS initiatives. Relying on the usefulness of signalling the
Introduction: The topic of this project was the expression and purification of Transient Receptor Potential Ankyrin 1 (TRPA1) from Anopheles gambiae, both the full length protein and a truncated version. Background: The structure of AgTRPA1 has not previously been determined, a step towards the determination is to express and purify the protein. Particular challenges working with AgTRPA1 are that
The purpose of this study is to investigate the relationship between ownership concentration and corporate performance in Chinese listed companies. Enriching the theory of corporate governance. The empirical foundation consists of data collected from 1468 listed companies at the Shanghai and Shenzhen Stock Exchanges in China, spanning 2018 to 2022. We observed a statistically significant positive
Artificial intelligence (AI) is an emerging technology with the potential to revolutionize the field of mental health. As the prevalence of mental health issues continues to rise, there is a growing need for effective and accessible interventions. This master’s thesis is done in collaboration with Prevas South in Malmö at the UX department. The scope of the project was to investigate how AI can be
Epilepsy is one of the most common neurological diseases that affects 1 % of the human population. After an initial insult, the brain undergoes several changes that lead to hyperexcitability. These changes include downregulation of both GABAA receptor subunits and CB1 receptors. These receptors normally work to decrease excitability, so their downregulation leads to an increase in excitability. If
As interest in social vulnerability to hazards grows, more indices are formulated for identifying and mapping population groups that may experience differential consequences from natural hazards. However, less attention has been given to the underlying choices researchers make when creating these indices. With the aim to contribute to understanding the issues surrounding social vulnerability indic
In this thesis methods for finding state space representation parameters for low inductance DC-motors are found and evaluated. Theory previously tested in simulations is verified experimentally and improved upon for both linear behaviour when the motor is controlled with a DC-source as well as nonlinear behaviour when controlled with pulse width modulation (PWM). For the linear behaviour a linear
This master thesis project has developed a method for a six-legged robot to traverse uneven terrains. From a previous project, the robot already possessed basic locomotion which had to be extensively redesigned. Several new subsystems have been introduced, such as a continuous balancing system, a system estimating the slope of the ground the robot is walking on, and method for detecting when the r
Interactions between T-cells and other body cells is an essential part of the immune system. It involves the binding between surface receptors of the two cells. Specifically, T-cell receptors (TCRs) bind onto pMHC (peptide-loaded major histocompatibility complex) molecules on the partnering cell surface. This way, a cell signal from the TCR to the nucleus can be initiated. Depending on the "m
Historiskt sett har transportören, med undantag för force majeure och krigshandlingar, varit strikt ansvarig för all skada på det transporterade godset. Detta kom att förändrades under slutet av 1800-talet och början av 1900-talet när transportörerna började begränsa sina ansvarsgrunder med klausuler i transportavtalen. Snart var transportörerna inte ansvariga för i princip någonting, vilket var pThe carrier has historically been strictly liable for all damage to the cargo carried, with the exception of acts of God and war. This changed during the late 1800’s and early 1900’s when the carriers began to limit their liabilities in the contract of carriage. They were soon not liable for very much which was problematic for the shippers, since they did not receive compensation when their goods
Uppsatsens syfte är att analysera hur genus kan göras och ogöras med fokus på kvinnor i relation med alkoholiserade män samt hur det avspeglar och påverkar marginalisering i det litauiska samhället. Undersökningen är avgränsad till en tidsperiod oktober 2016 och oktober 2018 och fokuserar på Litauen. I syfte att hitta relevanta artiklar och kartlägga kontexten i vilken dessa är producerade används
In Reinforcement learning the updating of the value functions determines the information spreading across the state/state-action space which condenses the valuebased control policy. It is important to have an information propagation across the value domain in a manner that is effective. Two common ways to update the value function is Monte-Carlo updating and temporal difference updating. They are
The main purpose of this explorative master thesis is to describe, explain and understand the main success factors that lie behind the regional innovation system in Silicon Wadi in Israel. This is done in order to suggest some tentative ideas on how to further develop the emerging ICT cluster in Malmö/Lund. Four sub purposes have been applied in order to achieve the main purpose: To understand why
High-Order Harmonic generation (HHG) is an alternative and much more compact way of generating x-ray radiation compared to producing it in a synchrotron. In this report a two color inline interferometer is designed to superimpose electrical fields generated by a frequency doubling crystal, for the purpose of reshaping the pulse train generated in the HHG process. The challenges of this design is t
Social Network Games (SNGs) first appeared in Asia in the latter half of the 00s, and soon became a widespread phenomenon all over the world. In the West, US developer Zynga quickly rose to fame with their hit title FarmVille, and now enjoys a nearly monopolistic position among games on Facebook. In Japan as well, the SNG industry has grown at an exceptional pace since its birth and is predicted t
The collective identity is under permanent negotiation. Due to the lack of incentive to offer public communication, the collective identity of Japanese bureaucrats; kanryo(官僚) has been constructed separately inside and outside of ministries. Firstly, I explore how the collective identity of kanryo has been constructed in two Japanese national newspapers. Also, the constructed identity of kanryo wi
In this master’s thesis, the possibility of increasing the load bearing capacity of glued timber joints by the use of a rubber foil was investigated. A rubber foil is believed to ensure a more uniform distribution of stresses and thereby greater load bearing capacity. The work within this master’s thesis consisted of developing material models for rubber based on experimental tests in order to en
Svampmycelet formas efter miljön Ett svampmycel är en komplex vegetativ enhet som påverkas av miljöfaktorer som till exempel näringstillgång. Detta är känt hos högre, frilevande, svampar som lever av döda växtdelar. Min studie visar att även svampar som lever i symbios med växter, utvecklar sitt mycel i direkt respons till omgivningen. Svampar har olika sätt att överleva. Svampen kan leva som sapAbstract The mycelium formation and foraging strategies of arbuscular mycorrhizal fungi (AMF) are not well understood, due to the biotrophic nature of these fungi, which makes cultivation methods without a host difficult. However, in-vitro-techniques have been developed in which AMF are inoculated on genetically transformed roots of various dicotyledonous plants. In the present study, monoxenic c
A sedimentlogical and palynological study of samples from the Middle Jurassic Fuglunda Member, Mariedal Formation at Eriksdal, Skåne, Sweden, has been carried out. The section is dominated by sandstone with minor units of coal, claystone, siltstone and conglomerate. The depositional environment has been interpreted as a coastal setting, perhaps a delta system with mixed influences of fluvial, tida
