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Background: Enzalutamide (ENZ), an androgen receptor antagonist therapy, was approved for patients (pts) with mCRPC. However, in standard of care for mCRPC pts, change in prostate specific antigen (PSA) is not accepted as an efficacy response measurement and the radiological change is inadequately measured in an interpreter-dependent subjective analysis of bone scan. Therefore, an objective effica

The study of slavery and coerced labour is increasingly conducted from a global perspective, and yet a dual Eurocentric bias remains: slavery primarily brings to mind the images of Atlantic chattel slavery, and most studies continue to be based – either outright or implicitly – on a model of northern European wage labour. This book constitutes an attempt to re-centre that story to Asia.With studie

Activation of the Met receptor tyrosine kinase, either by its ligand, hepatocyte growth factor (HGF), or via ligand-independent mechanisms, such as MET amplification or receptor overexpression, has been implicated in driving tumor proliferation, metastasis, and resistance to therapy. Clinical development of Met-targeted antibodies has been challenging, however, as bivalent antibodies exhibit agoni

HaptiMap is a high profile FP7 project to enhance the use and accessibility of mobile maps and location based services on mobile devices, through the integration of the tactile, audio and visual senses to augment applications when in non-ideal, noisy or poor-visibility situations. It provides an adaptable toolkit to aid developers in including accessibility functionality into, multi-modal mobile a

This document is an edited version of the original funding proposal entitled 'ORKG: Facilitating the Transfer of Research Results with the Open Research Knowledge Graph' that was submitted to the European Research Council (ERC) Proof of Concept (PoC) Grant in September 2020 (https://erc.europa.eu/funding/proof-concept). The proposal was evaluated by five reviewers and has been placed after the eva

Background: Generalized pustular psoriasis (GPP) is a severe form of pustular psoriasis with generalized eruption of sterile pustules, often along with systemic symptoms. There is a scarcity of population-based estimates of GPP prevalence and incidence. Objectives: To estimate (i) the prevalence and incidence of GPP in the Swedish general population and (ii) the prevalence of psoriasis vulgaris wi

A minimum-time lane change maneuver is executed under friction-limited conditions using (1) the Modified Hamiltonian Algorithm (MHA) suitable for real-time control and (2) numerical optimization for comparison. A key variable is the switching time of the acceleration reference in MHA. Considering that MHA is based on an approximate vehicle model to target real-time control, it cannot exactly match

Active generative cooling based on supercritical hydrocarbon fuel is regarded as one of the most promising methods for scramjet thermal management. A large eddy simulation method is used to explore the transient change law of the initial flow, and heat transfer behaviors of supercritical hydrocarbon fuel is in rectangular channels. An oscillation effect can be proved in the convective heat transfe

This article analyses the nature of policy debates on financial regulation during the onset of the Global Financial Crisis (GFC) by considering three elements that shape them: the salience of the debate, the actors that dominate the debate, and the degree of anti-status quo pressure. Theoretically, it contributes to Culpepper’s quiet/noisy politics framework by clarifying its multidimensionality a

The central role of the certificate authority (CA) in traditional public key infrastructure (PKI) makes it fragile and prone to compromises and operational failures. Maintaining CAs and revocation lists is demanding especially in loosely-connected and large systems. Log-based PKIs have been proposed as a remedy but they do not solve the problem effectively. We provide a general model and a solutio

Accessibility is increasingly recognised as a key purpose of transport policies. Most of the common practices found both in academic studies and policy planning draw on relatively simple accessibility measures taken as ‘objective’ indicators that only focus on the interaction between land use and transport. Relatively little attention has been paid to heterogeneity in individual characteristics an