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In animals, dihydroorotate dehydrogenase (DHODH) is a mitochondrial protein that carries out the fourth step in de novo pyrimidine biosynthesis. Because this is the only enzyme of this pathway that is localized to mitochondria and because the enzyme is cytosolic in some bacteria and fungi, we carried out studies to understand the mode of targeting of animal DHODH and its submitochondrial localizat

We synthesize the current understanding of glacier activity on Svalbard from the end of the Late Pleistocene (12,000 yrs. before present) to the end of the Little Ice Age (c. 1920 AD). Our glacier history is derived from the SVALHOLA database, the first compilation of Holocene geochronology for Svalbard and the surrounding waters, including over 1,800 radiocarbon, terrestrial cosmogenic nuclide an

Monarchy was the dominant form of rule in the pre-modern era and it persists in a handful of countries. We propose a unified theoretical explanation for its rise and decline. Specifically, we argue that monarchy offers an efficient solution to the primordial problem of order where societies are large and citizens isolated from each other and hence have difficulty coordinating. Its efficiency is ch

This article aims to enable a conversation between cosmopolitan thought, with focus on individual ethical experiences and reflections, and research on embodied military experiences. While we derive our ethical reasoning from cosmopolitanism, we concede that it lacks sensitivity to individuals’ other-regarding reflections and acts. Moreover, it does not sufficiently problematize the ways in which c

Under the influence of EU law and the ECHR, proportionality has developed into a central feature of contemporary European administrative law, on both the national and the Union level. The article examines this development with respect to the three EU Member States of Denmark, Finland and Sweden. These Nordic legal systems share certain fundamental conceptions of law, such as the limited importance

An efficient approach to reliability analysis of deteriorating structural systems is presented, which considers stochastic dependence among element deterioration. Information on a deteriorating structure obtained through inspection or monitoring is included in the reliability assessment through Bayesian updating of the system deterioration model. The updated system reliability is then obtained thr

An experiment on elastic scattering of 15 C on 208 Pb at an energy of 65 MeVwas performed at ISOLDE (CERN) exploiting the advantages of the ISOL te-chinique. The measurement showed in increase of the reaction cross section to3035 mb with respect to 12 C, confirming the results obtained at 80 MeV/u. Mea-surements to characterise and develop detector modules for the CALIFA setupwas performed for the

The damping ratio is a key performance measure in systems that can be modelled as networks of masses and springs. We derive a lower bound on this quantity that applies to such networks when the masses are subject to viscous damping. The result allows the size of the damping ratio to be understood as a function of the system parameters. We use this to derive a decentralised criterion which, if sati

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Prediabetes is a state of glycaemic dysregulation below the diagnostic threshold of type 2 diabetes (T2D). Globally, ~352 million people have prediabetes, of which 35–50% develop full-blown diabetes within five years. T2D and its complications are costly to treat, causing considerable morbidity and early mortality. Whether prediabetes is causally related to diabetes complications is unclear. Here

Context: The changes that are taking place with respect to environmental sensitivity are forcing organizations to adopt a new approach to this problem. Implementing sustainability initiatives has become a priority for the social and environmental awareness of organizations that want to stay ahead of the curve. One of the business areas that has, more than others, proven to be a vital asset and a p

Individuals with cancer may be at high risk for coronavirus disease 2019 (COVID-19) and adverse outcomes. However, evidence from large population-based studies examining whether cancer and cancer-related therapy exacerbates the risk of COVID-19 infection is still limited. Data were collected from the COVID Symptom Study smartphone application since March 29 through May 8, 2020. Among 23,266 partic

Most chronic and acute lung diseases have no cure, leaving lung transplantation as the only option. Recent work has improved our understanding of the endogenous regenerative capacity of the lung and has helped identification of different progenitor cell populations, as well as exploration into inducing endogenous regeneration through pharmaceutical or biological therapies. Additionally, alternativ

Background The scaphoid is the most commonly fractured carpal bone in adults as well as in children. Previous studies have reported a wide range of fracture incidences. Scaphoid fractures and non-unions in children have been sparsely investigated. Aim To perform a systematic review of the current literature on epidemiology of scaphoid fractures and non-unions in adults and children. Methods An ele

We study the adhesion and tensile behaviour of bi-layer interfaces comprising polyethylene, doped with carbonyl and hydroxyl functional groups emanating from ozone treatment, and - by means of density functional theory and classical atomistic modelling. The results show that the deformations are localized within the polymer and comprise chain slip, disentanglement and detachment from the substrate

Nanowire (NW) arrays containing a top segment of GaxIn1–xP are investigated, comparing NWs grown using two different Ga precursors, trimethylgallium (TMGa) and triethylgallium (TEGa). TMGa is the precursor commonly used for the particle-assisted vapor–liquid–solid (VLS) growth of GaxIn1–xP NWs. However, it shows inefficient pyrolysis at typical NW growth conditions. The use of the alternative prec