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A total of 3,016 malignant solid tumors (kidney, colorectal, breast, head and neck, ovarian, and lung carcinomas, neuroglial tumors, malignant melanoma, and testicular germ cell tumors) were selected for statistical analyses regarding karyotypic evolution. Genomic imbalances, i.e., net gains and losses, present in more than 5% of each tumor type were identified. Individual tumors were then classif
Methods for facile synthesis of symmetric and unsymmetric functionalized analogues of Tröger's base were developed with use of 2,8-dibromo-6H,12H-5,11-methanodibenzo[b,f][1,5]diazocine (2) as the starting material. C(2)-symmetric 2,8-disubstituted analogues of Tröger's base (4a-f) were synthesized via double bromine-lithium exchange of 2 followed by quench with electrophiles. Desymmetrization via
Reconstruction artifacts are a serious hindrance to the elucidation of phylogenetic relationships and a number of methods have been devised to alleviate them. Previous studies have demonstrated a striking disparity in the evolutionary rates of the mitochondrial (mt) genomes of squamate reptiles (lizards, worm lizards and snakes) and the reconstruction artifacts that may arise from this. Here, to e
Migratory birds use multiple sources of compass information for orientation, including the geomagnetic field, the sun, skylight polarization patterns and star patterns. In this paper we review the results of cue-conflict experiments designed to determine the relative importance of the different compass mechanisms, and how directional information from these compass mechanisms is integrated. We focu
An extensive set of proxy-data was acquired from eastern and central Denmark in order to study the dynamic behaviour of the southwestern margin of the last Scandinavian Ice Sheet. We examine the last three glacier advances of the Late Weichselian: the Main advance from central Sweden, representing the maximum ice extent at this time (c. 21-20 ka BP), and the two succeeding Baltic advances (c. 18-1
Ethylhydroxyethyl cellulose (EHEC) of three different viscosity classes (EHEC I, II, and III) was analyzed by programmed cross-flow asymmetrical flow field-flow fractionation coupled to multiangle light scattering and refractive index detectors to determine their size and molar mass distribution. Two size populations were detected in the two lower viscosity classes, EHEC I and II, one high molar m
Human blood coagulation Factor V(FV) is a plasma protein with little procoagulant activity. Limited proteolysis at Arg(709), Arg(1018), and Arg(1545) by thrombin or Factor Xa (FXa) results in the generation of activated FV, which serves as a cofactor of FXa in prothrombin activation. Both thrombin exosites I and II have been reported to be involved in FV activation, but the relative importance of
The effect of Phytophthora species, soil chemistry, precipitation and temperature on the vitality of oak was evaluated in 32 oak stands in southern Sweden. In addition, the relationship between the occurrence of Phytophthora species and soil conditions was determined. The results showed that there was a weak association between the presence of P. quercina, the most frequently recovered Phytophthor
Temperature not only has direct effects on microbial activity, but can also affect activity indirectly by changing the temperature dependency of the community. This would result in communities performing better over time in response to increased temperatures. We have for the first time studied the effect of soil temperature (5-50 degrees C) on the community adaptation of both bacterial (leucine in
Reaction of the tetradentate ligand N-(2-hydroxybenzyl)-N, N-bis(2-pyridylmethyl) amine (L - OH) with MoO2Cl2 in methanol in the presence of NaOMe and PF6- results in the formation of [MoO2(L - O)] PF6. Similarly, the reaction of N-(2-mercaptobenzyl)- N,N-bis(2-pyridylmethyl) amine (L -SH) with MoO2(acac)(2) leads to the formation of [MoO2(L - S)](+). The dioxo-molybdenum complex [MoO2(L - O)](+)
The occurrence and removal rate of seven pharmaceuticals (ibuprofen, naproxen, diclofenac, fluoxetine, ofloxacin, norfloxacin, ciprofloxacin), two metabolites (norfluoxetine, clofibric acid), one degradation product (4-isobutylacetophenone) and 3 estrogens (17alpha-ethinylestradiol, 17beta-estradiol, estrone) were studied in the inlet and outlet of a tertiary sewage treatment plant (STP) in Sweden
The oxyntic mucosa of the mammalian stomach is rich in endocrine cells, such as ECL cells, A-like cells, somatostatin cells, D1/P cells and, in some species, enterochromaffin cells. The various endocrine cell types can be distinguished on the basis of their characteristic cytoplasmic granules and vesicles. The ECL cells contain numerous large secretory vesicles and relatively few, small electron-d
This study investigates the relation between preferences and cognitive effort in decision making tasks in a natural setting. Does the way a supermarket’s shelves are organized affect how easy it is to choose what items to purchase? Does it affect the quality of our choice? The eye-movements of participants were recorded during their regular shopping trips in two supermarkets with different shelf
This is a comparative case study of the Committee of the Regions and regional offices. It explores using written records whether history can unveil contrasting features between these two systems using historical institutionalism as the guide. First, it examines the beginning of regional engagement in the European Union with the formation of European Regional Development Fund and the Single Europea
This thesis puts forward the idea that the radical other that constitutes and threatens our society is not to be found outside its limits, but that it is something inherent to our society. It proposes that the threatening other, the constitutive outside of society, is the subject 'the poor', that in its failure to partake in the labour market, fails to conform to the rules of the market, a
Eftersom folkrätten är ett högaktuellt rättsområde idag, är det lätt att tro att det också är en modern produkt, ett resultat av nutidens accelererande globalisering. Så är dock inte fallet, utan folkrätten har i högsta grad en rättshistorisk sida som bör beaktas. Denna uppsats undersöker hur Hugo Grotius och Emer de Vattel behandlade de centrala folkrättsliga begreppen stat och suveränitet, och Since public international law is a current area of law today, we may think that it is also a modern product, a result of today’s globalized world. However, that is not the case. Public international law has important historical aspects that must be considered. This paper examines in what way Hugo Grotius and Emer de Vattel treated two of the key concepts of public international law, state and so
