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In a recent paper, Miguel Sebastián has posed an objection to the higherorder thought theory of consciousness. The higher-order thought theory of consciousness holds that a mental state is conscious when it is the intentional object of a higher-order thought (HOT). Often, the HOT is conceived to be essentially indexical. This means that the HOT somehow picks out the individual who tokens it. Sebas
Ligand selectivity among the highly conserved galectins has been an ever-challenging objective. For galectin-8, a protein prevalent in both pathology and tissue distribution, we report phthalazinone-galactals that show excellent selectivity for the galectin-8N-terminal domain. A dissection of structure–activity relationships of the phthalazinone and an extensive molecular dynamics meta-analysis ac
High resolution observations with ALMA have revealed that concentric rings and gaps are common features in protoplanetary disks. The favored mechanism for creating these substructures are planet-disk interactions, in which growing planets open gaps in the disk, and particles become trapped at the pressure maxima that form at the corresponding gap edges. Since the particle density in these pressure
This paper discusses the characteristics of ZnO and ZnO:Ga ceramics fabricated by uniaxial hot pressing. The short-wavelength transmission limit of zinc oxide ceramics is in the 370-nm region; the long-wavelength limit is determined by the free-charge-carrier concentration and lies in the interval from 5 to 9 μm. The total transmittance of such ceramics in the visible and near-IR regions is about
Atomic layer etching (ALE) is a cyclic technique based on self-limiting processes, such as reactive gas adsorption and material removal by low-energy ion bombardment 1,2. In a typical ALE process Ar+ ions with energies of 20-60 eV are used to desorb the reaction products, e.g. SiClx for the Si ALE. Compared to a corresponding continuous reactive ion etching (RIE), where the ion energies often exce
Background: Atopic dermatitis (AD) is a common inflammatory skin disease while the economic burden of AD by severity is not adequately understood. Objective: To estimate the societal economic burden and to identify cost determinants of AD. Methods: In this population-based, controlled cohort study in Sweden, patients with AD were identified through diagnosis codes in primary or secondary care or b
Debates about the gendered division of labour tend to focus on negotiation and decision-making by couples in the present, and assume that individuals make rational choices based on present circumstances when deciding questions about workforce engagement, domestic labour and childcare responsibilities. As a result, they overlook the fact that choices made in the present are shaped by past choices.
Aims: According to Braak's hypothesis, it is plausible that Parkinson's disease (PD) originates in the enteric nervous system (ENS) and spreads to the brain through the vagus nerve. In this work, we studied whether inflammatory bowel diseases (IBDs) in humans can progress with the emergence of pathogenic α-synuclein (α-syn) in the gastrointestinal tract and midbrain dopaminergic neurons. Methods:
In the body, all cell surfaces are covered with glycans, and many regulatory components havecarbohydrates attached to them, which can aid in their function. Galectins are a family of proteins whichcan bind to specific glycans and oligosaccharides and cross-link them to influence a wide range of cellularprocesses. The members of the galectin family are structurally similar and can be involved in th
This study aimed to investigate how 6-bromoindirubin-3’-oxime (BIO) increases the osteogenic differentiation of canine bone mesenchymal stem cells (BMSCs) and the role of the Wnt/β-catenin signaling pathway in this process. We mimicked the effect of Wnt by adding BIO to the culture medium of BMSCs and examined whether canonical Wnt signaling positively affects the differentiation of these cells in
Combinations of theology and anthropology have been criticized for losing track of what theology ought to be about. Yet this loss might be precisely what enables scholars to understand political practices which point towards that which escapes both the theological and the anthropological grasp—a pointer which could be crucial to fashion solidarities that connect faiths in the pursuit of justice.
Context. Ultra-short-period planets (USPs) are a unique class of super-Earths with an orbital period of less than a day, and hence they are subject to intense radiation from their host star. These planets cannot retain a primordial H/He atmosphere, and most of them are indeed consistent with being bare rocky cores. A few USPs, however, show evidence for a heavyweight envelope, which could be a wat
This thesis presents fundamental studies on oxide-based catalysts and model catalysts used for the synthesis of renewable fuels. The two investigated oxide catalysts are In2O3(111) model catalysts and NiMo-oxide catalysts.The In2O3(111) surface is studied as a model system for In2O3-based catalysts used for CO2 hydrogenation to methanol. Specifically, the interaction of In2O3(111) with CO2, syngas
Natural selection generally favours phenotypic variability in camouflaged organisms, whereas aposematic organisms are expected to evolve a more uniform warning coloration. However, no comprehensive analysis of the phenotypic consequences of predator selection in aposematic and cryptic species exists. Using state-of-the-art image analysis, we examine 2800 wing images of 82 moth species accessed via
This clinical workshop is aimed at child and adolescent mental health professionals. The workshop will focus on two interventions found in all first-line, evidence-based treatments for PTSD: exposure to the trauma memory and reminders, and cognitive restructuring of trauma-related beliefs. Participants will learn about the various way that effective exposure can be achieved through writing, oral r
