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IMPORTANCE Peer deviance (PD) strongly predicts externalizing psychopathologic conditions but has not been previously assessable in population cohorts. We sought to develop such an index of PD and to clarify its effects on risk of drug abuse (DA). OBJECTIVES To examine how strongly PD increases the risk of DA and whether this community-level liability indicator interacts with key DA risk factors a
The tightly controlled network of cell cycle genes consists of a core of cyclin dependent kinases (CDKs) that are activated by periodically expressed cyclins. The activity of the cyclin-CDK complexes is regulated by cyclin dependent kinase inhibitors (CDKIs) and multiple signal transduction routes that converge on the cell cycle. Neuroblastoma are pediatric tumors that belong to the group of small
"Foreword: The durability of building materials, especially the corrosion of reinforcement in concrete structures, has been a main research area in Scandinavia during the last decades. Results from many laboratories in the Scandinavian countries, and outside of Scandinavia, indicate that there are certain relationships between the service life and different concrete parameters, such as the water/b
Popular Abstract in Swedish Spraytorkning är ett vanligt sätt att tillverka partiklar från en lösning. Genom att finfördela lösningen med hjälp av gas i ett spraymunstycke bildas miljontals små vätskedroppar, som blandas med varm torkgas i en torkkammare. Då avdunstar vätskan och fasta, torra partiklar bildas. Tekniken kan användas för att tillverka inhalationspartiklar för användning som läkemedeThe interest in spray drying for production of inhalable particles has grown considerably since the late 1980s. However, which process variables that control degradation and the solid state properties have not been subject to extensive research. This thesis deals with how important characteristics of inhalation particles can be controlled, i.e. particle size, morphology, degradation and crystalli
After emigrating from England to Canada in the late 1970s, Robin Wood gained wide recognition as a major “Canadian” film critic, but he was criticized by some for his luke-warm response to the cinema of his adopted country. That response can be traced, in part, to the influence of the English literary critic F.R. Levis, but also to intellectual trends and cultural preferences Wood shared with othe
Along a stream, we investigated whether the abundance of stone loach (Barbatula barbatula, L.) was related to the presence of brown trout (Salmo trutta, L.) and instream habitat variables. First, a field survey was carried out where different habitat variables and the densities of both species were quantified and subjected to principal components analysis. Then the abundance of stone loach was rel
The 70Ni nucleus has been produced at the LISOL facility and its beta decay to 70Cu has been observed. In parallel, the 70Cu nucleus has been produced at the ISOLDE facility. A new third beta-decaying isomeric state in 70Cu has been identified, partly with the aid of the in-source laser spectroscopy method. Its measured half-life is T1/2=33(2) s. In addition, two isomeric transitions in 70Cu have
Human activity is constantly causing environmental problems due to production and release of numerous chemicals. A group of compounds of special concern is persistent organic pollutants (POP). These toxic, lipophilic chemicals have a high chemical and biological stability, and tend to accumulate in the lipid phase of living organisms. A major sink for POPs are sediments, and consequently these are
The metabolic syndrome includes a cluster of dysfunctions that identifies subjects at high risk of developing type 2 diabetes and cardiovascular disease. The prevalence of the metabolic syndrome has increased markedly over the last two decades. Central to this syndrome is insulin resistance and hyperglycaemia, but also other manifestations, e.g. central obesity, dyslipidaemia, elevated blood press
This article argues that the depictions of Gnostic sects performing horrendous rites in Epiphanius of Cyprus’ work Panarion worked as rhetorical devices to shift focus away from his own position vis-à-vis marriage, sex, and consumptions of good food and wine, a position that was considered liberal in the context of fourth century eccle- siastical debates. It here is shown how Epiphanius’ descripti
Background: It remains unclear whether heritable factors can contribute to risk stratification for ischemic stroke in patients with atrial fibrillation (AF). We examined whether having a sibling with ischemic stroke was associated with increased risk of ischemic stroke and mortality in patients with AF. Methods and Results: In this nationwide study of the Swedish population, patients with AF and t
Abstract: Okadaic acid (OA) is a frequently used phosphatase inhibitor that by inhibiting dephosphorylation increases the net phosphorylation level in various systems. In the present study OA was used to assess the role of balanced phosphorylation‐dephosphorylation reactions for successful regeneration of peripheral nerves. To achieve this, the effects of OA on phosphorylation levels, neurite outg
Objective: This study investigated the effect of alpha-ketoglutarate sodium salt (AKG) and ipriflavone (IP) treatment on the mineralization of the tibia in male rats during the development and after the establishment of osteopenia. Design: One hundred and twenty eight male rats were randomly selected and submitted to either sham-operation (SHO) or orchidectomy (ORX), after which each group were th
Background: There is an urgent need for effective treatments against glioblastoma (GBM). In this trial, we investigated the efficacy and safety of an adoptive cell-based immunotherapy. Methods: Patients with newly diagnosed GBM were recruited at 4 study sites in Sweden. The patients were randomized 1:2 to receive either radiotherapy (RT), 60 Gy/30 fractions, with concomitant and adjuvant temozolom
Background: The Autism- Tics, ADHD and other Comorbidities inventory (A-TAC) has been validated in epidemiological data. However, validation against clinical diagnostic assessments in a population-based sample has been lacking, limiting the implications for clinical practice, clinical research and public health decisions. Methods: Study participants were recruited from the longitudinal Child and A
There is an increasing focus on the importance of reducing red meat consumption for environmental as well as health reasons. In this study, we have assessed how consumers' choice of protein source in a meal could be affected by two nudging tools. The first nudge consisted of serving a plant-based steak as the default option instead of beef, alongside placing the plant-based steak at the top of theThere is an increasing focus on the importance of reducing red meat consumption for environmental as well as health reasons. In this study, we have assessed how consumers' choice of protein source in a meal could be affected by two nudging tools. The first nudge consisted of serving a plant-based steak as the default option instead of beef, alongside placing the plant-based steak at the top of the
This study reveals specific ion effects on particle formation during peristaltic pumping of a monoclonal Antibody (Antibody A). For this purpose, three anions in the direct Hofmeister series were selected, ranging from the kosmotropic SO42- to the more neutral Cl- and the chaotropic SCN-. Protein particle formation during peristaltic pumping is described primarily as a surface-driven mechanism. Th
The times they are a-changin’ – a letter to LTH's students Hoppa till huvudinnehåll Vi använder cookies och andra spårningsteknologier för att förbättra användarupplevelsen på vår webbplats, för att visa dig personligt innehåll och riktade annonser och för att analysera vår webbplatstrafik. Läs mer om cookies. Absolut nödvändiga cookies Dessa cookies är nödvändiga för att webbplatsen ska fungera o
https://www.lth.se/article/the-times-they-are-a-changin-a-letter-to-lths-students/ - 2026-10-06
