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Several groups have during past years produced molecular classification schemes for bladder cancer. Even though no consensus on how to define a subtype exists, one approach has been to base definitions on how tumours cluster according to their mRNA expression profiles. In many cases, obtained profiles, and thus class defining features, are affected by signals from non-tumour cells within the biops
AIM: This study investigated childhood diagnoses in children born extremely preterm before 24 weeks of gestation.METHODS: Diagnoses of neurodevelopmental disorders and selected somatic diagnoses were retrospectively retrieved from national Swedish registries for children born before 24 weeks from 2007 to 2018. Their individual medical files were also examined.RESULTS: We studied 383 children born
This report highlights investigations since 2016 on the Large Igneous Provinces (LIPs), particularly based on their mafic dyke swarms (MDSs) and continental flood basalts (CFBs), from the Indian Shield. Recent research, particularly geochemistry, geochronology and paleomagnetism, allow identification and characterization of distinct generations of LIPs in space and time in the Indian Shield. This
Summary: Codon sequences can influence proteins to misfold during cotranslational folding. Here, we develop an in vivo assay in E. coli to comprehensively study the impact of single synonymous substitutions on protein folding efficiency and apply it to the N-terminal domain of ddlA. By mapping the influence of codons along the sequence, we show that codon identity can substantially influence foldi
β-Ga2O3 is a promising ultrawide-bandgap semiconductor for high-power and optoelectronic applications; yet, its intrinsically low thermal conductivity poses challenges for heat dissipation. To clarify how strain and size effects govern phonon transport, we investigate bulk β-Ga2O3 under biaxial tensile strain and finite-size confinement using first-principles calculations and the phonon Boltzmann
This article explores the dynamics of state control and specific workings of state power by ethnographically examining the ways in which Chinese grassroots labor NGOs negotiate and gauge the unclear parameters permitted by the Chinese state in South China. By closely examining the everyday activism at the margins of the Chinese state, I argue that the uncertainty about the limits of the state’s to
Although Scandinavia is arguably peripheral in the global literary system, it nevertheless holds a surprisingly prominent position in the field of translation, Swedish and Danish being among the ten most translated languages in the world (Lindqvist, 2015). What literature is selected for translation and introduction into new linguistic contexts is not a coincidence, but has to do with economic fac
Background: Severe eosinophilic asthma is a high-burden disease. Mepolizumab has been effective in several randomized clinical trials. However, such success might not be applicable to patients treated in usual clinical practice. The objectives of this article are to evaluate the efficacy of mepolizumab in severe uncontrolled eosinophilic asthma under usual clinical practice, and to determine chara
Apolipoprotein A-I (ApoA-I) is the major protein constituent of high-density lipoprotein particles, and as such is involved in cholesterol transport and activation of LCAT (the lecithin:cholesterol acyltransferase). It may also form amyloidal deposits in the body, showing the multifaceted interactions of ApoA-I. In order to facilitate the study of ApoA-I in various systems, we have developed a pro
This report concerns six cases of multiple myeloma characterized by either no demonstrable monoclonal immunoglobulin in plasma or urine or by trace amounts (less than or equal to 0.1 g/l) of monoclonal kappa chains in the urine. In all cases there was an infiltration of the bone marrow by plasma cells containing kappa chains but no heavy chains. A retrospective analysis was made of 126 consecutive
Today the newly emerging Chinese MNEs have increasingly been involved in the internationalization activities, but they have not attracted adequate attention in terms of internationalization studies. This paper will be based on Dunning’s Eclectic (OLI) Paradigm as theoretical foundation and deploy the method of case study to analyze the internationalization strategy of the Chinese high-technology M
The 68-kDa homodimeric 3C-like protease of SARS-CoV-2, Mpro (3CLpro/Nsp5), is a promising antiviral drug target. We evaluate the concordance of models generated by the newly introduced AlphaFold2 structure prediction program with residual dipolar couplings (RDCs) measured in solution for 15N-1HN and 13C′-1HN atom pairs. The latter were measured using a new, highly precise TROSY-AntiTROSY Encoded R
Intro: Population-based studies predominantly focused on carcinoma of the parotid gland (CPG) are rare. The study aims were to analyze the incidence of CPG and to assess treatment outcomes in relation to histopathology, preoperative diagnosis and adjuvant radiotherapy. Methods: A retrospective analysis was conducted on data from the Swedish Head and Neck Cancer Register (SweHNCR), including 1,018
Background/Objectives: Mitochondrial dysfunction is a major cause of brain injury in patients with primary mitochondrial disease. New mitochondrial therapeutics and non-invasive tools for efficacy monitoring are urgently needed. To these ends, succinate prodrug NV354 (methyl 3-[(2-acetylaminoethylthio)carbonyl]propionate) and diffuse optical techniques are promising. In this proof-of-concept study
The sorting of high-ability workers is often advanced as one source of spatial disparities in economic outcomes. There are still few papers that analyze when human capital sorting occurs and whom it involves. Using data on 16 cohorts of university graduates in Sweden, we demonstrate significant sorting to urban regions on high school grades and education levels of parents, i.e., two attributes typ
In recent years, there has been an increasing amount of literature on critical thinking and deep learning. Conversely, the traditional pedagogical methods of teaching lack the potentiality to make deep learning especially for the practice-oriented courses such as programming languages. Thus, this study is designed based on the Project-Based Learning (PBL) and Role-Playing (RP) which are integrated
Multilayer graphene has exhibited distinct electronic properties such as the tunable bandgap for optoelectronic applications. Among all graphene growth techniques, thermal decomposition of SiC is regarded as a promising method for production of device-quality graphene. However, it is still very challenging to grow uniform graphene over a large-area, especially multilayer graphene. One of the main
The role of exogenous sources of new path development has been underplayed in the literature on regional industrial change so far. The aim of this article is to explore in a conceptual way under which conditions and in what ways non-local knowledge can lead to new path development in different regional innovation systems (RISs). We distinguish between organizationally thick and diversified RISs, t
