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Chronic myeloid leukemia (CML) is genetically characterized by the Philadelphia (Ph) chromosome, formed through a reciprocal translocation between chromosomes 9 and 22 and giving rise to the constitutively active tyrosine kinase P210 BCR/ABL1. Therapeutic strategies aiming for a cure of CML will require full eradication of Ph chromosome-positive (Ph(+)) CML stem cells. Here we used gene-expression

OBJECTIVE: Decades after an acute poliomyelitis infection many persons experience new symptoms or impairments which may affect their life satisfaction. The objective of this study was to investigate the association between life satisfaction and self-reported impairments in persons with late effects of polio. MATERIAL AND METHODS: One hundred and sixty-nine persons (104women and 65men) with prior p

Exhaustion is hypothesised to be a risk-factor for coronary heart disease (CHD), but as such its independence from emotional states, in particular depression, has not been established in previous investigations. This study aimed to explore the unique contribution of exhaustion, independent from symptoms of depression and anxiety, to CHD development.

PURPOSE: The study aimed to (1) optimize the radiation doses of computed tomography (CT) of paranasal sinuses, (2) compare the radiation doses of different CT protocols with that of plain radiography, and (3) evaluate the reliability of low-dose CT in the detection of pathology and characterization of the detected pathology. MATERIALS AND METHODS: A head phantom was examined with different scan pa

Treatment with docetaxel is the standard of care as first line chemotherapy in castration resistant prostate cancer. Due to serious side effects from the commercially available Taxotere formulation, we aimed to develop a safe and effective nanoparticle formulation of docetaxel. Liquid crystal nanoparticles (LCNPs), based on phosphatidyl choline, glycerol dioleate and polysorbate 80 dispersed in ex

The planktonic food chain phytoplankton - zooplankton - young-of-the-year roach (Rutilus rutilus) was studied in 19 lakes in southern Sweden to investigate the bioaccumulation of polychlorinated biphenyls (PCBs). The Sigma PCB concentrations did not steadily increase with increasing trophic level. The Sigma PCB concentrations in zooplankton (400 ng.g lipid(-1)) were lower than in both phytoplankto

Osteoporosis is a major health problem affecting more than 75 million people throughout Europe, USA and Japan. Epidemiological studies have determined that both genetic and environmental factors contribute to the pathogenesis of osteoporosis. We have investigated the association between polymorphisms at the osteocalcin locus and variables linked to bone health. Osteocalcin provides a link between

In December 2005, the WTO responded to the HIV/AIDS pharmaceutical crisis in the least developed world by voting to make the first permanent amendment to the WTO Agreements since their original negotiation during the Uruguay Round. New Article 31bis will amend the TRIPS Agreement to permit compulsory manufacturing licenses in order to facilitate supply of needed pharmaceuticals to those countries

A remote sensing system for combined fluorescence spectral recordings and multi-colour fluorescence imaging of vegetation will be presented. The system configuration will be explained and data from several field campaigns will be shown. The excitation light pulses for remote fluorescence detection are produced by a frequency tripled Nd:YAG laser emitting at 355 nm and shifted to 397 nm in a deuter

In the political and medial discourse of the 1930s the contract-work system (stat/ar/ systemet) was depicted as a relic of pre-modern society and contract-workers (statare) as the highly exploited lower class with no legal rights, low incomes, miserable housing conditions and a chaotic family life. This picture has dominated Swedish social history ever since, and the main argument of this article

One of the obstacles that seem to impede a more frequent application of the modelling and simulation approach system dynamics (SD) in the software engineering community is the lack of well-defined and repeatable procedures for generating or using information that (a) stems from real industrial software development practice and (b) is suitable for SD model building. This problem can be resolved, at

A methodology for studying change processes in working life combining computer-aided planning and cooperation in project groups is evaluated. The methodology is applied and studied in a planning workshop with representatives from manufacturing industries—managers, production engineers, supervisors as well as shop floor workers—and from health-and-safety agencies utilizing the methodology for plann

The S.T.A.R. Design Studio (Space and Terrestrial Architectural Research) studies pre-industrial habitats in i.a. Tanzania, and develops design concepts for future habitats in space in cooperation with Johnson Space Centre, Houston, Texas. In both cases our studies focus on "extreme" circumstances. Perhaps studying the conditions of a crew sealed in a capsule can better prepare us for the problems