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Wilms tumor (WT) is characterized by a nonrandom pattern of chromosome aberrations, but the clinical significance of different cytogenetic patterns is unknown. The present study describes the cytogenetic findings and the clinical course in a cohort of 39 children with WT. Samples for short-term culturing and cytogenetic analysis were obtained during a 15-year period. Clonal chromosome aberrations
Isometric force, glycogen phosphorylase activity and lactate production were measured under conditions known to alter intracellular Ca2+ and cAMP to assess the role of these messengers in the coordination of metabolism with contractility in rat portal vein. Total phosphorylase (a + b) activity, was independent of treatment. The activity ratio phosphorylase activity ratio in the presence of isoprot
A new trend in recent years is to reduce the solid oxide fuel cell (SOFC) operating temperature to an intermediate range by employing either a thin electrolyte, or new materials for the electrolyte and electrodes. In this paper, a numerical investigation is presented with focus on modeling and analysis of transport processes in planar intermediate temperature (IT, between 600 and 800 degrees C) SO
The effects of restrained cervical mobility on pursuit eye movements (PEMS), voluntary saccades and postural control, as measured by posturography, were studied in 11 healthy subjects whose cervical spine movement had been restrained for 5 days by means of a rigid neck-collar. At day 5 mean peak velocity of voluntary saccades at amplitudes of 40 degrees and 60 degrees was significantly reduced, as
Cystatin F is a recently discovered type II cystatin expressed almost exclusively in immune cells. It is present intracellularly in lysosome-like vesicles, which suggests a potential role in regulating papain-like cathepsins involved in antigen presentation. Therefore, interactions of cystatin F with several of its potential targets, cathepsins F, K, V, S, H, X and C, were studied in vitro. Cystat
The main concern of this thesis is to experimentally investigate the turbulent flow and heat transfer in a ribbed channel. Such flows are encountered in many engineering applications, e.g., gas turbine cooling. In order to highlight the physical mechanism of flow separation, only one wall of the channel is fitted with periodic ribs. The inter-rib spacing is set such that the reattachment is allowe
Participants tend to falsely remember a nonpresented critical word after having studied a list of the word's primary associates. We present here a Swedish version of the Deese-Roediger-McDermott paradigm, which provides a tractable method of experimentally inducing and investigating such illusory memories. In Experiment 1 it was demonstrated that the constructed stimulus material induced highly re
Chloride profiles were measured on ten different concrete qualities. The effect of two different cements, an ordinary Portland cement, OPC, and a sulfate-resistent Portland cement, SRPC, with and without inclusion of silica fume and fly ash was investigated. The samples were exposed to a 3 wt% sodium chloride solution for 119 days. Two different preparations before exposure were studied. Both type
Conditions for predicting the effects of intervention with certainty are derived. An outside observer studies sequences of actions from a two-person repeated prisoners' dilemma. The sequences are generated by finite automata, which are optimal at each stage of the game and also minimize the number of states. An intervention is a change of action for one of the players and a prediction is a stateme
The use of short interfering RNAs (siRNA) for selective suppression of protein production has rapidly become a commonly used technique for transient modulation of protein levels. In the present paper, we investigate whether introduction of platinated bases in the sense strand can be used to modulate the efficacy of siRNAs. Four different siRNAs were studied, all targeting the initial AU-rich 3' UT
Highly efficient anti-blood group A and B immunoadsorbents for extracorporeal treatment were developed by immobilizing A and B trisaccharide and A tetrasaccharide haptens on Sepharose 4FF and Fractogel TSK using three different methods. The adsorption of the IgG and IgM anti-A antibodies was essentially the same regardless of the A hapten used or the method of oligosaccharide coupling. The adsorpt
An investigation of Thapsia garganica afforded a series of tetracyclic C-19 dilactones, whose production was dependent on the time and location of the collection. These unusual tetrahomosesquiterpenoids are presumably biosynthesized via a carbon dioxide-triggered electrophilic polyolefin cyclization. Despite the structural differences with thapsigargin, these compounds showed SERCA-inhibiting prop
This thesis is concerned with developing a consistent regional perspective on the Massim peoples of southeastern Papua New Guinea, a task largely neglected by earlier anthropological studies, it is claimed, or, when sometimes attempted, unsuccessfully accomplished for a number of reasons, both methodological and theoretical. The author uses a comparative approach for investigating a selection of
The algorithmic content of adaptive ODE/DAE software is dominated by a considerable amount of control structures, support algorithms and logic. The control logic has been largely heuristic and lacking support by analysis. In this thesis we study adaptive time-stepping based on control theory, combined with other carefully selected control strategies. Thus we argue that ODE/DAE software can be cons
